Results 101 to 110 of about 110,429 (168)

The Role of Arp2/3 in End‐Resection During DNA Double‐Strand Break Repair

BioEssays, Volume 48, Issue 9, September 2026.
Arp2/3 has an evolutionarily conserved role in promoting 5’ to 3’ resection of DSBs, RAD51 filament formation, maintenance of the DNA damage checkpoint, increased mobility of DSBs, and relocation of damage in heterochromatin regions to the nuclear periphery.
Felix Y. Zhou, James E. Haber
wiley   +1 more source

Intermediate Filament Protein BFSP2 Controls Spindle Formation via HSC70‐Mediated Stabilization of CLTC During Oocyte meiosis

Advanced Science
As a major component of the cytoskeleton, intermediate filaments are generally considered to play a supporting role in mitotic cells. They also take part in the regulation of cell motility, proliferation, differentiation, and apoptosis.
Yu Li, Zihao Zhang, Yu Zhang, Bo Xiong
doaj   +1 more source

CDK-1 inhibits meiotic spindle shortening and dynein-dependent spindle rotation in C. elegans

, 2011
In animals, the female meiotic spindle is positioned at the egg cortex in a perpendicular orientation to facilitate the disposal of half of the chromosomes into a polar body.
Francis J. McNally, Marina L. Ellefson
core   +1 more source

PCH-2 collaborates with CMT-1 to proofread meiotic homolog interactions.

PLoS Genetics, 2020
The conserved ATPase, PCH-2/TRIP13, is required during both the spindle checkpoint and meiotic prophase. However, its specific role in regulating meiotic homolog pairing, synapsis and recombination has been enigmatic.
Stefani Giacopazzi, Daniel Vong, Alice Devigne, Needhi Bhalla   +3 more
doaj   +1 more source

Ipl1/Aurora kinase suppresses S-CDK-driven spindle formation during prophase I to ensure chromosome integrity during meiosis.

PLoS ONE, 2013
Cells coordinate spindle formation with DNA repair and morphological modifications to chromosomes prior to their segregation to prevent cell division with damaged chromosomes.
Louise Newnham, Philip W Jordan, Jesus A Carballo, Sonya Newcombe, Eva Hoffmann   +4 more
doaj   +1 more source

Spindle assembly timelapse with augmin

, 2022
Timelapse images of meiotic spindle self-organization in Xenopus egg extracts supplemented with purified augmin holocomplex (red: tubulin; green: DNA) 
Yuta Shimamoto (13041201), Tatsuya Fukuyama (13127912)   +1 more
core   +1 more source

Clathrin is essential for meiotic spindle function in oocytes

, 2010
In the mammalian ovary, oocytes are arrested at prophase of meiosis I until a hormonal stimulus triggers resumption of meiosis. During the subsequent meiotic maturation process, which includes completion of the first meiotic division and formation of the
Biology of Reproductive Cells, Crystal and Structural Chemistry, Wieger Hemrika, Algemeen Onderzoek DGK, Roland A P Romijn, Dep Biochemie en Celbiologie, Bernard A J Roelen, Hemrika, W., van Haeften, T., Roelen, B.A.J., Colenbrander, B., Sub Crystal and Structural Chemistry, Dep Gezondheidszorg Landbouwhuisdieren, Romijn, R.A.P., Theo van Haeften, Ben Colenbrander, Stoorvogel, W., Willem Stoorvogel, Hölzenspies, J.J., Jurriaan J Hölzenspies   +19 more
core   +1 more source

Intermediate Filament Protein BFSP1 Maintains Oocyte Asymmetric Division by Modulating Spindle Length

Advanced Science
The cytoskeleton is composed of microtubules, microfilaments, and intermediate filaments in cells. While the functions of microtubules and microfilaments have been well elucidated, the roles of intermediate filaments and associated proteins remain ...
Yu Li, Hanwen Zhang, Wenjun Zeng, Yilong Miao, Shaochen Sun, Yu Zhang, Bo Xiong   +6 more
doaj   +1 more source

Effects of cryopreservation on the meiotic spindle, cortical granule distribution and development of rabbit oocytes [PDF]

, 2012
Cryopreservation of embryos and oocytes in animal species is considered an important tool in reproduction biotechnology. The aim of this study was to evaluate the effect of vitrification and slow-freezing on the meiotic spindle, cortical granule ...
Jiménez Trigos, María Estrella
core  

Multiple requirements of PLK1 during mouse oocyte maturation.

PLoS ONE, 2015
Polo-like kinase 1 (PLK1) orchestrates multiple events of cell division. Although PLK1 function has been intensively studied in centriole-containing and rapidly cycling somatic cells, much less is known about its function in the meiotic divisions of ...
Petr Solc, Tomoya S Kitajima, Shuhei Yoshida, Adela Brzakova, Masako Kaido, Vladimir Baran, Alexandra Mayer, Pavlina Samalova, Jan Motlik, Jan Ellenberg   +9 more
doaj   +1 more source