Results 71 to 80 of about 98,848 (186)
Advanced Science, EarlyView.Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han +10 more
wiley +1 more source
Magneto‐X Effects in Magnetic Soft Materials and Their Applications
Advanced Science, EarlyView.This review systematically explores magnetic soft materials (MSMs), a novel class of composites that transform under magnetic fields. It catalogs fundamental “Magneto‐X” effects, classifies materials by their matrix and magnetic fillers, and highlights transformative applications in soft robotics, biomedical devices, flexible electronics, etc. Finally,
Ziyin Xiang +5 more
wiley +1 more source
Acquisitions Facilitation via Blockchain Technology
Blockchain in Healthcare Today, 2018 Session Description: ACCELERATE is a transformative program in support of HHS ReImagine Acquisition. It is designed to empower the workforce in a decentralized manner and create a flexible capability for HHS to change and implement policy.
Oki Mek, Aleksandar Zelenovic
doaj
RAF Suppression Synergizes with MEK Inhibition in KRAS Mutant Cancer Cells
Cell Reports, 2014 KRAS is the most frequently mutated oncogene in human cancer, yet no therapies are available to treat KRAS mutant cancers. We used two independent reverse genetic approaches to identify components of the RAS-signaling pathways required for growth of KRAS
Simona Lamba +9 more
doaj +1 more source
Artificial Intelligence for Bone: Theory, Methods, and Applications
Advanced Intelligent Discovery, EarlyView.Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan +3 more
wiley +1 more source
Molecular Pain, 2006 Background Numerous studies have implicated spinal extracellular signal-regulated kinases (ERKs) as mediators of nociceptive plasticity. These studies have utilized pharmacological inhibition of MEK to demonstrate a role for ERK signaling in pain, but ...
Kaplan David +4 more
doaj +1 more source
Proactive Robotic Grasp Stability via Tactile Safety Margin Feedback
Advanced Intelligent Systems, EarlyView.We introduce the tactile safety margin (TSM), defined as the ratio between applied friction force (Ffric) and maximum friction (Fmax) derived from grip force. A bilayer E‐skin with decoupled temperature, strain, and pressure sensing enables real‐time grasp stability monitoring through measured TSM values, allowing robots to proactively adjust grip ...
Yebin Park +10 more
wiley +1 more source
The 9th International RASopathies Symposium
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT The RASopathies are a group of congenital disorders with overlapping clinical manifestations that are caused by pathogenic germline or early somatic variants that result in the hyperactivation of the RAS/mitogen‐activated protein kinase (MAPK) signaling pathway.
Pau Castel +41 more
wiley +1 more source
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT A comprehensive synthesis of the broad range of neurodevelopmental and psychiatric manifestations in NF1 is needed to identify knowledge gaps and future directions for NF1 research. In the following scoping review, we identify and summarize the scope of research that examines neurodevelopmental and psychiatric manifestations, both as ...
Meera Chopra +5 more
wiley +1 more source
Jurnal Kimia Valensi, 2018 Jalur sinyal protein kinase Ras-Raf-MEK-ERK adalah salah satu target penting dalam penemuan obat antikanker. Senyawa turunan benzamida diketahui berpotensi sebagai inhibitor alosterik Mitogen Enhanced Kinase (MEK).
Muhammad Arba +4 more
doaj +1 more source