Results 11 to 20 of about 13,359 (150)

Allele-Specific GNAQ Q209 Mutations Reveal Context-Dependent Oncogenic Programs in Uveal Melanoma. [PDF]

Pigment Cell Melanoma Res
Using matched immune‐competent, multistep uveal melanoma models, we show that GNAQ Q209L and Q209R mutations are not functionally equivalent. Q209L drives faster in vivo progression but reduces in vitro proliferation and migration, whereas Q209R promotes greater in vitro fitness and preferential FAK‐YAP activation, revealing an allele‐dependent ...
Jarajapu V, Neelature Sriramareddy S, Mecozzi N, Wang K, Karreth FA, Xu X.   +5 more
europepmc   +2 more sources

Rapidly Progressive Metastatic Sertoli Cell Tumor Associated With an Adenomatous Polyposis Coli Mutation: A Case Report and Literature Review. [PDF]

IJU Case Rep
ABSTRACT Introduction Sertoli cell tumors are rare testicular sex cord‐stromal tumors, and clinically malignant behavior is uncommon. We report a rapidly progressive metastatic Sertoli cell tumor associated with an APC mutation. Case Presentation A 27‐year‐old man with familial adenomatous polyposis (FAP) presented with painless right scrotal ...
Obayashi K, Terasaki M, Hasegawa H, Mikami H, Yanagi M, Takeda H, Endo Y, Toyama Y, Ohashi R, Akatsuka J.   +9 more
europepmc   +2 more sources

The Importance of Immunohistochemistry in the Evaluation of Tumor Depth of Primary Cutaneous Melanoma

Diagnostics, 2023
Primary cutaneous melanoma (PCM) is the most aggressive skin malignancy, with an increasing incidence and significant mortality. Tumoral invasion, expressed as Breslow thickness, is routinely assessed on hematoxylin and eosin (HE), although this stain ...
Anca Maria Pop, Monica Monea, Peter Olah, Raluca Moraru, Ovidiu Simion Cotoi   +4 more
doaj   +1 more source

Cytological Features of Clear Cell Sarcoma in Exfoliative and Effusion Cytology Specimen-A Case Report and Literature Review. [PDF]

Diagn Cytopathol
ABSTRACT Clear cell sarcoma of soft tissue (CCSST) with malignant effusion is a rare yet clinically aggressive appearance, which may pose a diagnostic pitfall with its overlapping cytomorphologic features with metastatic melanoma and carcinoma.
Wu WH, Ng JKM, Li JJX.
europepmc   +2 more sources

Medullary Thyroid Carcinoma Showing Melanocytic Differentiation: A Report of a Rare Case

Endocrinology Research and Practice, 2015
Medullary thyroid carcinoma (MTC) accounts for 5-10% of all thyroid malignancies. These tumors show variable morphological features, however, to the best of our knowledge, melanocytic differentiation is rare with only 11 reported cases.
Serap Karaarslan, Yeşim Ertan, Mehmet Hüsnü Buğdaycı, Funda Taşlı, Durkaya Ören, Taner Akalın   +5 more
doaj   +1 more source

On the peculiarities of seborrheic keratosis pigmentation

Vestnik Dermatologii i Venerologii, 2019
Seborrheic keratosis (SK) is a common benign epithelial skin tumor that exists in a variety of clinical op - tions. The color of the tumor varies from yellow to dark brown, which leads to diagnostic errors. There is аlittle data about pigmentation of the
A. K. Alexandrova, V. A. Smolyannikova
doaj   +1 more source

Primary Melanoma of the Lung: A Systematic Review

Medicina, 2020
Background and Objectives: The respiratory apparatus, generally affected by highly aggressive tumors like lung cancer and mesothelioma, is rarely affected by primary malignant melanoma.
Panagiotis Paliogiannis, Antonella M. Fara, Gianfranco Pintus, Wael M. Abdel-Rahman, Maria Colombino, Milena Casula, Giuseppe Palmieri, Antonio Cossu   +7 more
doaj   +1 more source

ACTIVATED CHARCOAL: A NATURAL PROTECTIVE MEASURE AGAINST THE LINGUAL DEGENERATIVE EFFECT OF TACROLIMUS IMMUNOSUPPRESSANT [PDF]

Alexandria Dental Journal
Objective: The presented work was conducted to test the effectiveness of activated charcoal on the lingual mucosa of male rats subjected to the immunosuppressive drug tacrolimus.
Hagar Abdel Fattah, Marwa Essawy, Amira Eissa   +2 more
doaj   +1 more source

SOX11, SOX10 and MITF Gene Interaction: A Possible Diagnostic Tool in Malignant Melanoma

Life, 2021
Malignant melanoma (MM) is a highly heterogenic tumor whose histological diagnosis might be difficult. This study aimed to investigate the diagnostic and prognostic utility of the conventional pan-melanoma cocktail members (HMB-45, melan-A and tyrosinase)
Marius-Alexandru Beleaua, Ioan Jung, Cornelia Braicu, Doina Milutin, Simona Gurzu   +4 more
doaj   +1 more source

Antigen-specificity and DTIC before peptide-vaccination differently shape immune-checkpoint expression pattern, anti-tumor functionality and TCR repertoire in melanoma patients

OncoImmunology, 2018
We have recently described that DNA-damage inducing drug DTIC, administered before peptide (Melan-A and gp100)-vaccination, improves anti-tumor CD8+ Melan-A-specific T-cell functionality, enlarges the Melan-A+ TCR repertoire and impacts the overall ...
Belinda Palermo, Ornella Franzese, Cosmo Di Donna, Mariangela Panetta, Concetta Quintarelli, Isabella Sperduti, Novella Gualtieri, Maria Laura Foddai, Enrico Proietti, Virginia Ferraresi, Gennaro Ciliberto, Paola Nisticò   +11 more
doaj   +1 more source