Results 91 to 100 of about 46,735 (181)
Activation and endocytic internalization of melanocortin 3 receptor in neuronal cells
The FASEB Journal, 2006 Essential hypertension oftentimes clusters with obesity and insulin resistance but the mechanisms underlying the association are unknown. Studies with gene knockout mice have implicated autonomic melanocortin receptors, MC3R and MC4R, in the pathophysiology of obesity, insulin resistance and salt‐sensitive hypertension.
James Munuhe Wachira +2 more
openaire +1 more source
Investigation on variability of candidate genes for meat quality traits in Piemontese cattle
Italian Journal of Animal Science, 2010 This study aimed to investigate the variability of 15 genes chosen according to their function as markers of meat quality traits in Piemontese cattle. Meat samples of Longissimus thoracis muscle and data on carcass weight (CW), shear force (SF), cooking ...
Luigi Gallo +5 more
doaj +1 more source
Melanocortin-3 receptor expression in AgRP neurons is required for normal activation of the neurons in response to energy deficiency. [PDF]
Cell Rep, 2023 Gui Y +5 more
europepmc +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 9, Page 7768-7778, September 2026.ABSTRACT Background The obesity pharmacotherapy landscape is evolving rapidly, with several approved incretin‐based therapies and an expanding pipeline of investigational compounds targeting multiple metabolic pathways. Conventional evidence syntheses often struggle to accommodate differences in dose selection, treatment duration and stage of clinical ...
Matteo Monami +2 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 15, 15 August 2026.CtBP2, a transcriptional corepressor with metabolite sensing capabilities, maintains feeding homeostasis by preventing excessive food intake in the hypothalamic feeding center. CtBP2 limits food intake by inhibiting KLF4 within AgRP neurons and by promoting the inhibitory influence of POMC neurons on AgRP neurons.
Wanpei Chen +15 more
wiley +1 more source
The Parallel Structure-Activity Relationship Screening of Three Compounds Identifies the Common Agonist Pharmacophore of Pyrrolidine Bis-Cyclic Guanidine Melanocortin-3 Receptor (MC3R) Small-Molecule Ligands. [PDF]
Int J Mol Sci, 2023 Ericson MD +8 more
europepmc +1 more source
Metabolic Regulation of Macrophages in Health and Disease
MedComm, Volume 7, Issue 8, August 2026.Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang +6 more
wiley +1 more source
Molecular Genetics &Genomic Medicine, Volume 14, Issue 8, August 2026.A novel MC4R mutation (c.185A > G) was identified in a 10‐year‐old girl with severe obesity and hyperinsulinemia. Retrospective analysis of 64 pediatric cases revealed that mutation location influences BMI, modulated by underlying disease status, demonstrating that the genotype–phenotype relationship in MC4R‐associated obesity is clinically context ...
Xin Li +4 more
wiley +1 more source
Melanocortin 3 receptor-expressing neurons in the ventromedial hypothalamus promote glucose disposal. [PDF]
Proc Natl Acad Sci U S A, 2021 Sutton Hickey AK +6 more
europepmc +1 more source
The FASEB Journal, Volume 40, Issue 13, 15 July 2026.Active immunization with recombinant THSD7A in mice induces autoreactive B cell activation and differentiation into CD138+ antibody‐secreting cells, leading to the production of anti‐THSD7A autoantibodies, glomerular immune injury and proteinuria, characteristic of membranous nephropathy. NDP‐MSH treatment modulates the MITF/IRF4 axis in primed B cells,
Mingzhuo Zhang +4 more
wiley +1 more source