Results 101 to 110 of about 46,735 (181)

Natural dual inhibitor isorhamnetin-3-O-neohespeidoside targets tyrosinase and MC1R for skin pigmentation management

Scientific Reports
Skin pigmentation disorders involve complex biological regulation, with tyrosinase (TYR) and melanocortin 1 receptor (MC1R) serving as key therapeutic targets.
Rongrong Deng, Shiqian Zheng, Shengjun Xie, Gengjiu Huang, Zhiwen Ou, Zhibin Shen   +5 more
doaj   +1 more source

A Dimer for Dinner: The Impact of GHS-R1a Heterodimerization on Feeding Circuits

Biomolecules
Growth hormone-releasing hormone receptor 1a (GHS-R1a) is a key G protein-coupled receptor (GPCR) governing feeding and energy homeostasis. Accumulating evidence shows that GHS-R1a forms functional heterodimers with multiple metabolic-related GPCRs ...
Tingting Tang, Qingli Zhang, Tingting Song, Dan Ding, Dejiu Zhang, Yan Zhang, Zichu Zhao, Jingjing Kong, Qu Chen, Lei Zhu, Hailong Li   +10 more
doaj   +1 more source

Subthreshold activation of the melanocortin system causes generalized sensitization to anorectic agents in mice

The Journal of Clinical Investigation
The melanocortin-3 receptor (MC3R) regulates GABA release from agouti-related protein (AgRP) nerve terminals and thus tonically suppresses multiple circuits involved in feeding behavior and energy homeostasis.
Naima S. Dahir, Yijun Gui, Yanan Wu, Patrick R. Sweeney, Alix A.J. Rouault, Savannah Y. Williams, Luis E. Gimenez, Tomi K. Sawyer, Stephen T. Joy, Anna K. Mapp, Roger D. Cone   +10 more
doaj   +1 more source

Whole-brain efferent and afferent connectivity of mouse ventral tegmental area melanocortin-3 receptor neurons. [PDF]

J Comp Neurol, 2021
Dunigan AI, Swanson AM, Olson DP, Roseberry AG.   +3 more
europepmc   +1 more source

Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign. [PDF]

J Med Chem, 2021
Doering SR, Freeman K, Debevec G, Geer P, Santos RG, Lavoi TM, Giulianotti MA, Pinilla C, Appel JR, Houghten RA, Ericson MD, Haskell-Luevano C.   +11 more
europepmc   +1 more source

Supraphysiological Glucocorticoid Doses and Pitfalls of Annual Biomarker Monitoring in Adults With CAH

Clinical Endocrinology, Volume 105, Issue 3, Page 360-362, September 2026.
Jakob Bolinder, Oskar Ragnarsson, Gudmundur Johansson   +2 more
wiley   +1 more source

Searching for the relationship between the parameters of metabolic syndrome and the rs17782313 (T>C) polymorphism of the MC4R gene in postmenopausal women

Clinical Interventions in Aging, 2017
Jacek Brodowski,1 Małgorzata Szkup,2 Anna Jurczak,2 Sylwia Wieder-Huszla,2 Agnieszka Brodowska,3 Maria Laszczyńska,4 Beata Karakiewicz,5 Katarzyna Kęcka,1 Elżbieta Grochans2 1Primary Care Department, Pomeranian Medical University in Szczecin ...
Brodowski J, Szkup M, Jurczak A, Wieder-Huszla S, Brodowska A, Laszczyńska M, Karakiewicz B, Kęcka K, Grochans E   +8 more
doaj  

Preliminary investigation of potential links between pigmentation variants and opioid analgesic effectiveness in horses during cerebrospinal fluid centesis

BMC Veterinary Research
Background The pleiotropic effects of the melanocortin system show promise in overcoming limitations associated with large variations in opioid analgesic effectiveness observed in equine practice. Of particular interest is variation in the melanocortin-1-
Elouise K. Bacon, Callum G. Donnelly, Rebecca R. Bellone, Bianca Haase, Carrie J. Finno, Brandon D. Velie   +5 more
doaj   +1 more source

The association of the fat mass and obesity-associated gene (FTO) rs9939609 polymorphism and the severe obesity in a Brazilian population

Diabetes, Metabolic Syndrome and Obesity, 2019
Ana Carolina Proença da Fonseca,1 Gabriella Medeiros Abreu,1 Verônica Marques Zembrzuski,1 Mario Campos Junior,1 João Regis Ivar Carneiro,2 José Firmino Nogueira Neto,3 Giselda Maria Kalil Cabello,1 Pedro Hernán Cabello1,
da Fonseca ACP, Abreu GM, Zembrzuski VM, Campos Junior M, Carneiro JRI, Nogueira Neto JF, Cabello GMK, Cabello PH   +7 more
doaj  

The accessory protein MRAP2 directly interacts with melanocortin-3 receptor to enhance signaling. [PDF]

Sci Signal
Jamaluddin A, Wyatt RA, Lee J, Dowsett GKC, Tadross JA, Broichhagen J, Yeo GSH, Levitz J, Gorvin CM.   +8 more
europepmc   +1 more source