Results 121 to 130 of about 58,907 (217)

Effect of NDP-a-MSH on PPAR-c and –b Expression and Anti-Inflammatory Cytokine Release in Rat Astrocytes and Microglia [PDF]

, 2013
Brain inflammation plays a central role in numerous brain pathologies. Microglia and astrocytes are the main effector cells that become activated when an inflammatory process takes place within the central nervous system. a-melanocytestimulating hormone (
Carniglia, Lila, Caruso, Carla Mariana, Durand, Daniela Elizabeth, Lasaga, Mercedes Isabel   +3 more
core   +1 more source

Both MC1 and MC3 Receptors Provide Protection From Cerebral Ischemia-Reperfusion-Induced Neutrophil Recruitment. [PDF]

, 2015
Objective Neutrophil recruitment is a key process in the pathogenesis of stroke, and may provide a valuable therapeutic target. Targeting the melanocortin receptors (MC) has previously shown to inhibit leukocyte recruitment in peripheral inflammation ...
Cooper, D., Cooper, D., Cvek, U., Cvek, U., Durrenberger, P.F., Durrenberger, P.F., Gavins, F.N., Gavins, F.N., Getting, S.J., Getting, S.J., Holloway, P.M., Holloway, P.M., Orr, A.W., Orr, A.W., Perretti, M., Perretti, M., Trutschl, M., Trutschl, M.   +17 more
core   +1 more source

Involvement of central opioid and melanocortin receptors in spexin-induced hypophagia following intracerebroventricular injection in neonatal broiler chicks

BMC Veterinary Research
Background Numerous physiological properties have been documented in the literature pertaining to spexin, such as its role in appetite regulation. Therefore, the present research aimed to assess the impacts of centrally administering spexin and its ...
Mohanna Badri, Samad Alimohammadi, Morteza Zendehdel, Shahin Hassanpour   +3 more
doaj   +1 more source

Binding, thermodynamics, and selectivity of a non-peptide antagonist to the melanocortin-4 receptor [PDF]

, 2018
The melanocortin-4 receptor (MC4R) is a potential drug target for treatment of obesity, anxiety, depression, and sexual dysfunction. Crystal structures for MC4R are not yet available, which has hindered successful structure-based drug design.
Clark, Timothy, Heyder, Nicolas, Hildebrand, Peter W., Kleinau, Gunnar, Saleh, Noureldin, Scheerer, Patrick   +5 more
core   +2 more sources

Defining Acquired Hypothalamic Obesity: An Expert Call for Unified Diagnosis and Therapeutic Action

Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 4437-4441, June 2026.
Hanneke M. van Santen, Ashley H. Shoemaker, Mehul T. Dattani, Christian L. Roth, Mohamad Maghnie, Kevin C. J. Yuen, Christine Poitou, Hermann L. Müller   +7 more
wiley   +1 more source

Coat Color of Korean Brindle Cattle and Melanocortin 1 Receptor (MC1R) mRNA: Variation of 3'-Untranslated Region and Expression

Journal of Animal Reproduction and Biotechnology, 2014
The objective of this study was to determine the breed differences in the 3'-untranslated region (UTR) of MC1R mRNA, which may be used to distinguish Korean brindle cattle (Chikso) from other breeds. We investigated the relationship between the variation
Hae-Lee Lee, Jae-Hee Park, Jong Gug Kim
doaj   +1 more source

Neuronal human BACE1 knock-in induces systemic diabetes in mice [PDF]

, 2016
Acknowledgements The authors thank S. Tammireddy (Diabetes and Cardiovascular Science, University of the Highlands and Islands, Inverness, UK) for technical support with the lipidomics component. Funding We would like to thank R.
Dekeryte, Ruta, Delibegovic, Mirela, Doherty, Mary K., Koss, David, Mingarelli, Marco, Mody, Nimesh, Platt, Bettina, Pluci??ska, Kaja, Riedel, Gernot, Shearer, Kirsty, Welch, Andy, Whitfield, Phillip, Whitfield, Phillip D.   +12 more
core   +4 more sources

Investigation on variability of candidate genes for meat quality traits in Piemontese cattle

Italian Journal of Animal Science, 2010
This study aimed to investigate the variability of 15 genes chosen according to their function as markers of meat quality traits in Piemontese cattle. Meat samples of Longissimus thoracis muscle and data on carcass weight (CW), shear force (SF), cooking ...
Luigi Gallo, Fabio Maretto, Valentina Bonfatti, Andrea Albera, Giovanni Bittante, Cinzia Ribeca   +5 more
doaj   +1 more source

Genetics of Severe Obesity [PDF]

, 2018
Purpose of Review This review aims to present current information on genes underlying severe obesity, with the main emphasis on the three genes LEP, LEPR and MC4R.
Fairbrother, U, Kidd, E, Malagamuwa, T, Walley, AJ   +3 more
core   +1 more source

Activation and endocytic internalization of melanocortin 3 receptor in neuronal cells

The FASEB Journal, 2006
Essential hypertension oftentimes clusters with obesity and insulin resistance but the mechanisms underlying the association are unknown. Studies with gene knockout mice have implicated autonomic melanocortin receptors, MC3R and MC4R, in the pathophysiology of obesity, insulin resistance and salt‐sensitive hypertension.
James Munuhe Wachira, Lawrence Uradu, Cleo Hughes‐Darden   +2 more
openaire   +1 more source