Results 141 to 150 of about 46,735 (181)

The Role of the Melanocortin‐3 Receptor in Cachexia

Annals of the New York Academy of Sciences, 2003
Abstract: Cachexia refers to a synergistic combination of a dramatic decrease in appetite and an increase in metabolism of fat and lean body mass. This combination is found in a number of chronic diseases and is an important determinant of mortality. In this paper, we provide evidence that in both acute and chronic disease models, blockade of the MC4 ...
Daniel L, Marks, Roger D, Cone
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The polymorphisms of bovine melanocortin-3 receptor pseudogene

Research in Veterinary Science, 2011
Mammalian melanocortin-3 receptor (MC3R) plays an important role in the central control of energy homeostasis, and several functional polymorphisms of mc3r have been detected. Interestingly, the bovine mc3r was a pseudogene, and its polymorphisms and function remain to be investigated.
C L, Zhang, Y H, Wang, C Z, Lei, X T, Fang, H, Chen   +4 more
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Pharmacological characterization of three chicken melanocortin-3 receptor mutants

Domestic Animal Endocrinology, 2021
The melanocortin-3 receptor (MC3R) is a G protein-coupled receptor and potentially important in production traits. Three naturally occurring mutations (M54L, G104S, and L151R) in chicken MC3R (cMC3R) were reported previously to be associated with production traits.
H.-J. Zhang, Z.-H. Cui, M. Liu, T.-Q. Min, X. Xiao, Z.-Q. Wang, Y.-X. Tao   +6 more
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Melanocortin 3 receptors control crystal‐induced inflammation

The FASEB Journal, 2006
In this study we have characterized the anti‐inflammatory profile of a selective melanocortin type 3 receptor (MC3‐R) ligand [D‐Trp 8 ]‐γ‐MSH, validating in vitro results with analyses in mice deficient for this receptor subtype.
Stephen J, Getting, Connie W, Lam, Airu S, Chen, Paolo, Grieco, Mauro, Perretti   +4 more
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Rattus norvegicus melanocortin 3 receptor: A corrected sequence

Peptides, 2005
Examination of the Rattus norvegicus genome reveals differences in the melanocortin 3 receptor (MC3R) compared with the published sequence (accession X70667). To clarify these differences, we used RT-PCR to clone MC3R from Sprague Dawley rats. These efforts revealed a sequence for the rat MC3R consistent with that predicted by the rat genome, but ...
Derek, Daniels, Aae, Suzuki, Edan, Shapiro, Laiyi, Luo, Daniel K, Yee, Steven J, Fluharty   +5 more
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Molecular Characterization of Human Melanocortin-3 Receptor Ligand−Receptor Interaction

Biochemistry, 2006
Melanocortin-3 receptor (MC3R), primarily expressed in the hypothalamus, plays an important role in the regulation of energy homeostasis. MC3R-deficient (MC3R(-)(/)(-)) mice demonstrate increased fat mass, higher feeding efficiency, hyperleptinaemia, and mild hyperinsulinism.
Min, Chen, Charles J, Aprahamian, Ahmet, Celik, Keith E, Georgeson, W Timothy, Garvey, Carroll M, Harmon, Yingkui, Yang   +6 more
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Mutations in Melanocortin-3 Receptor Gene and Human Obesity

2016
The prevalence of obesity calls for novel therapeutic targets. The melanocortin-3 receptor (MC3R) has been increasingly recognized as an important regulator of energy homeostasis and MC3R has been intensively analyzed in molecular genetic studies for obesity-related traits.
Z, Yang, Y-X, Tao
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Activation and Endocytic Internalization of Melanocortin 3 Receptor in Neuronal Cells

Annals of the New York Academy of Sciences, 2007
Abstract: Melanocortins play a central role in autonomic modulation of metabolism by acting through a family of highly homologous G protein–coupled receptors. Studies with gene knockout mice have implicated neural melanocortin receptors, MC3R and MC4R, in the etiology of obesity, insulin resistance, and salt‐sensitive hypertension.
S J M, Wachira, B, Guruswamy, L, Uradu, C A, Hughes-Darden, F J, Denaro   +4 more
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Functional characterization of the mouse melanocortin 3 receptor gene promoter

Gene, 2015
Melanocortin receptor 3 (MC3R) is expressed in the hypothalamus and pituitary in humans and rodents, and is involved in the control of feeding, energy metabolism, and pituitary function. In the mouse pituitary, MC3R is detected in mammotrophs. This study aimed to clarify the regulatory mechanism for Mc3r expression in the mouse pituitary.
Keisuke, Okutsu, Fumiya, Ojima, Naoto, Shinohara, Shusuke, Taniuchi, Yasusyo, Mizote, Kenji, Aoki, Toshiyuki, Kudo, Maho, Ogoshi, Sakae, Takeuchi, Sumio, Takahashi   +9 more
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Pharmacology of the giant panda (Ailuropoda melanoleuca) melanocortin-3 receptor

General and Comparative Endocrinology, 2019
The melanocortin-3 receptor (MC3R) is a member of the G protein-coupled receptor superfamily that plays a critical role in controlling energy balance and metabolism. Although pharmacological characterization of MC3R has been reported previously in several other species, there is no report on the MC3R from giant panda (Ailuropoda melanoleuca).
Hai-Jie Zhang, Hua-Jie Xie, Wei Wang, Zhi-Qiang Wang, Ya-Xiong Tao   +4 more
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