Results 151 to 160 of about 46,735 (181)

Functions of the Third Intracellular Loop of the Human Melanocortin-3 Receptor

Current Pharmaceutical Design, 2013
The melanocortin-3 receptor (MC3R) is a G protein-coupled receptor involved in regulating energy metabolism, cardiovascular function, and inflammation. To gain a better understanding of the structure-function relationship of the MC3R, we used alanine-scanning mutagenesis to investigate the functions of residues 247-273 in the third intracellular loop ...
Zhi-Qiang, Wang, Ya-Xiong, Tao
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The Melanocortin-3 Receptor

2000
This chapter deals with perhaps the least understood receptor for the melanocortin peptides, that is the melanocortin-3 receptor (MC3-R). Although naturally occurring and genetically engineered mutations have provided us with insight into the function of the other known melanocortin receptors, little is known about the physiologic role of the MC3-R ...
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Postnatal Expression of Melanocortin-3 Receptor in Rat Diencephalon and Mesencephalon

Neuropharmacology, 1997
In situ hybridization was applied to examine the postnatal expression of melanocortin-3 (MC-3) receptor mRNA in the rat brain. Very weak and limited signals were seen in the hypothalamus on postnatal day 0 (P0) and in the dorsal lateral thalamus on P4. A marked increase was noted in several regions of the diencephalon and mesencephalon on P7.
Y, Xia, J E, Wikberg
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Cell autonomous regulation of the activation of AgRP neurons by the melanocortin-3 receptor

2023
SUMMARY The melanocortin-3 receptor (MC3R) is a negative regulator of the central melanocortin circuitry via presynaptic expression on AgRP nerve terminals, from where it regulates GABA release onto secondary MC4R-expressing neurons. Hence, animals lacking MC3R (MC3R KO) exhibit hypersensitivity to MC4R agonists.
Yijun Gui, Naima S. Dahir, Griffin Downing, Patrick Sweeney, Roger D. Cone   +4 more
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Association Analysis of Melanocortin 3 Receptor Polymorphisms with the Risk of Pulmonary Tuberculosis

Lung, 2014
Melanocortin 3 Receptor (MC3R) is one of the families of seven-transmembrane G-protein-coupled receptors, and a recent study showed that MCR3 promoter polymorphism was significantly associated with the susceptibility of tuberculosis (TB) in South African population.We analyzed six MC3R polymorphisms to examine the genetic effects on the risk of ...
Byung Lae, Park, Lyoung Hyo, Kim, Suhg, Namgoong, Ji On, Kim, Jason Yongha, Kim, Hun Soo, Chang, Jong Sook, Park, An Soo, Jang, Sung Woo, Park, Do Jin, Kim, Ki Up, Kim, Yang Gee, Kim, Soo-Taek, Uh, Ki Hyun, Seo, Young Hoon, Kim, Choon Sik, Park, Hyoung Doo, Shin   +16 more
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Pharmacological function of melanocortin-3 receptor in goldfish (Carassius auratus)

General and Comparative Endocrinology
The melanocortin-3 receptor (MC3R) was recognized for its critical role in energy metabolism and inflammatory responses in mammals; however, its functions in fish remain poorly understood. This study characterized the mc3r gene in goldfish, investigating its sequence, tissue distribution, and pharmacological responses.
Ming-Xing, Yao, Yu-You, Du, Hao-Lin, Mo, Yasmeen, Gul, Qing-Chuan, Song, Hui-Xia, Yu, Ke-Xin, Liu, Li-Xin, Wang, Yang, Li   +8 more
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Melanocortin-3 receptor activates MAP kinase via PI3 kinase

Regulatory Peptides, 2007
HEK 293 cells stably expressing human melanocortin-3 receptor (MC3R) were exposed to melanocortin receptor agonist, NDP-MSH (10(-)(10)-10(-)(6) M). ERK1/2 was phosphorylated in a dose-dependent manner with an EC(50) of 3.3+/-1.5 x 10(-)(9) M, similar to the IC(50) of NDP-MSH binding to the MC3R.
Biaoxin, Chai, Ji-Yao, Li, Weizhen, Zhang, John B, Ammori, Michael W, Mulholland   +4 more
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Pharmacological comparison of rat and human melanocortin 3 and 4 receptors in vitro

Regulatory Peptides, 2002
The melanocortin 3 and 4 receptors are G-protein-coupled receptors found in the hypothalamus with important role in regulation of the energy balance. In this study, we performed pharmacological comparison of the rat and human melancortin (MC) 3 and MC4 receptors.
Helgi B, Schiöth, Amin A, Bouifrouri, Richard, Rudzish, Ruta, Muceniece, Hajime, Watanobe, Jarl E S, Wikberg, Dan, Larhammar   +6 more
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Melanocortin 3 receptor (MC3R) gene variants in extremely obese women

International Journal of Obesity, 2000
Following several reports of linkage of obesity related phenotypes to human chromosome 20q we sought to determine whether variations of the melanocortin 3 receptor (MC3R) gene are associated with obesity.We screened the MC3R gene coding region and approximately 2 kb of 5' and 3' flanking sequences for DNA variants in unrelated extremely obese women and
W D, Li, E J, Joo, E B, Furlong, M, Galvin, K, Abel, C J, Bell, R A, Price   +6 more
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Identification of Three Novel Genetic Variants in the Melanocortin‐3 Receptor of Obese Children

Obesity, 2011
The melanocortin‐3 receptor (MC3R), a G‐protein‐coupled receptor expressed in the hypothalamus, is a key component of the leptin‐melanocortin pathway that regulates energy homeostasis. It is suggested that an MC3R defect leads to an increased feed efficiency, by which nutrients are partitioned preferentially into fat.
Zegers, Doreen, Beckers, Sigri, de Freitas, Fenna, Peeters, Armand V., Mertens, Ilse L., Verhulst, Stijn L., Rooman, Raoul P., Timmermans, Jean-Pierre, Desager, Kristine N., Massa, Guy, Van Gaal, Luc F., Van Hul, Wim   +11 more
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