Results 131 to 140 of about 58,907 (217)

Taking Two to Tango: A Role for Ghrelin Receptor Heterodimerization in Stress and Reward

Frontiers in Neuroscience, 2013
The gut hormone, ghrelin, is the only known peripherally derived orexigenic signal. It activates its centrally expressed receptor, the growth hormone secretagogue receptor (GHS-R1a), to stimulate food intake.
Harriet eSchellekens, Timothy G Dinan, Timothy G Dinan, Timothy G Dinan, John F Cryan, John F Cryan, John F Cryan   +6 more
doaj   +1 more source

IDENTIFICATION OF MELANOCORTIN 1 RECEPTOR (MC1R) GENE BASED ON COAT COLOR OF BALI COWS OF KUPANG BY USINGTHE PCR-RFLP METHOD

Journal of the Indonesian Tropical Animal Agriculture, 2014
The objective of this study was to identify the Melanocortin 1 Receptor (MC1R) gene in sorrel-,black- and white-Bali cows originated from Kupang-East Nusa Tenggara.
A.C. Tabun, T. Hartatik, S. Sumadi
doaj   +1 more source

Melanocortin-3 receptor expression in AgRP neurons is required for normal activation of the neurons in response to energy deficiency. [PDF]

Cell Rep, 2023
Gui Y, Dahir NS, Wu Y, Downing G, Sweeney P, Cone RD.   +5 more
europepmc   +1 more source

The Parallel Structure-Activity Relationship Screening of Three Compounds Identifies the Common Agonist Pharmacophore of Pyrrolidine Bis-Cyclic Guanidine Melanocortin-3 Receptor (MC3R) Small-Molecule Ligands. [PDF]

Int J Mol Sci, 2023
Ericson MD, Freeman KT, LaVoi TM, Donow HM, Santos RG, Giulianotti MA, Pinilla C, Houghten RA, Haskell-Luevano C.   +8 more
europepmc   +1 more source

The melanocortin-3 receptor is a pharmacological target for the regulation of anorexia. [PDF]

Sci Transl Med, 2021
Sweeney P, Bedenbaugh MN, Maldonado J, Pan P, Fowler K, Williams SY, Gimenez LE, Ghamari-Langroudi M, Downing G, Gui Y, Hadley CK, Joy ST, Mapp AK, Simerly RB, Cone RD.   +14 more
europepmc   +1 more source

Functional characterization of novel melanocortin-3 receptor mutations identified from obese subjects

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2007
It is controversial whether mutation in the melancortin-3 receptor (MC3R) gene is a cause for monogenic obesity in humans. Three novel mutations in the MC3R, A293T, I335S, and X361S, were identified from morbidly obese subjects. We investigated whether these mutations caused loss-of-function and the molecular defects if any.
openaire   +2 more sources

Natural dual inhibitor isorhamnetin-3-O-neohespeidoside targets tyrosinase and MC1R for skin pigmentation management

Scientific Reports
Skin pigmentation disorders involve complex biological regulation, with tyrosinase (TYR) and melanocortin 1 receptor (MC1R) serving as key therapeutic targets.
Rongrong Deng, Shiqian Zheng, Shengjun Xie, Gengjiu Huang, Zhiwen Ou, Zhibin Shen   +5 more
doaj   +1 more source

Subthreshold activation of the melanocortin system causes generalized sensitization to anorectic agents in mice

The Journal of Clinical Investigation
The melanocortin-3 receptor (MC3R) regulates GABA release from agouti-related protein (AgRP) nerve terminals and thus tonically suppresses multiple circuits involved in feeding behavior and energy homeostasis.
Naima S. Dahir, Yijun Gui, Yanan Wu, Patrick R. Sweeney, Alix A.J. Rouault, Savannah Y. Williams, Luis E. Gimenez, Tomi K. Sawyer, Stephen T. Joy, Anna K. Mapp, Roger D. Cone   +10 more
doaj   +1 more source

Whole-brain efferent and afferent connectivity of mouse ventral tegmental area melanocortin-3 receptor neurons. [PDF]

J Comp Neurol, 2021
Dunigan AI, Swanson AM, Olson DP, Roseberry AG.   +3 more
europepmc   +1 more source

Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign. [PDF]

J Med Chem, 2021
Doering SR, Freeman K, Debevec G, Geer P, Santos RG, Lavoi TM, Giulianotti MA, Pinilla C, Appel JR, Houghten RA, Ericson MD, Haskell-Luevano C.   +11 more
europepmc   +1 more source