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Pharmacological function of melanocortin-3 receptor in goldfish (Carassius auratus)
General and Comparative EndocrinologyThe melanocortin-3 receptor (MC3R) was recognized for its critical role in energy metabolism and inflammatory responses in mammals; however, its functions in fish remain poorly understood. This study characterized the mc3r gene in goldfish, investigating its sequence, tissue distribution, and pharmacological responses.
Ming-Xing, Yao +8 more
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Functions of the Third Intracellular Loop of the Human Melanocortin-3 Receptor
Current Pharmaceutical Design, 2013The melanocortin-3 receptor (MC3R) is a G protein-coupled receptor involved in regulating energy metabolism, cardiovascular function, and inflammation. To gain a better understanding of the structure-function relationship of the MC3R, we used alanine-scanning mutagenesis to investigate the functions of residues 247-273 in the third intracellular loop ...
Zhi-Qiang, Wang, Ya-Xiong, Tao
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Melanocortin 3 receptor gene and melanocortin 4 receptor gene mutations: the Asian Perspective
Diabetes/Metabolism Research and Reviews, 2012SummaryMelanocortin 4 receptor (MC4R) deficiency resulting from disruption of one or both MC4R alleles represents the commonest monogenic form of human obesity to date. Human MC4R deficiency was reported to affect 4 and 5.8% of severely obese French and British populations respectively.
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Regulation of Energy Rheostasis by the Melanocortin-3 Receptor
The regulation of energy homeostasis is complex, however key physiological systems have been identified. The melanocortin system has been demonstrated to be a master regulator of energy homeostasis. Within the melanocortin system are the melanocortin-3 or -4 receptors (MC3R & MC4R).openaire +2 more sources
Critical care management of chimeric antigen receptor T‐cell therapy recipients
Ca-A Cancer Journal for Clinicians, 2022Alexander Shimabukuro-Vornhagen +2 more
exaly
Melanocortin-1-receptor gene and sun sensitivity in individuals without red hair
Lancet, The, 2000Eugene Healy
exaly
Clinical Spectrum of Obesity and Mutations in the Melanocortin 4 Receptor Gene
New England Journal of Medicine, 2003I Sadaf Farooqi, Stephen O'rahilly
exaly
Melanocortin 3 Receptor: A Novel Mediator Of Exercise-induced Inflammation
Medicine & Science in Sports & Exercise, 2009Tara M. Henagan +5 more
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