Results 171 to 180 of about 60,342 (231)

High-resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery. [PDF]

Elife
Howard CJ, Abell NS, Osuna BA, Jones EM, Chan LY, Chan H, Artis DR, Asfaha JB, Bloom JS, Cooper AR, Liao A, Mahdavi E, Mohammed N, Su AL, Uribe GA, Kosuri S, Dickel DE, Lubock NB.   +17 more
europepmc   +1 more source

Strategies to deliver peptide drugs to the brain [PDF]

, 2014
Lalatsa, Katerina, Schatzlein, Andreas G., Uchegbu, Ijeoma F.   +2 more
core   +1 more source

Melanocortin-4 receptor antagonist TCMCB07 alleviates chemotherapy-induced anorexia and weight loss in rats. [PDF]

J Clin Invest
Zhu X, Potterfield R, Gruber KA, Zhang E, Newton SD, Norgard MA, Levasseur PR, Bai P, Chen X, Gu Q, Grossberg AJ, Marks DL.   +11 more
europepmc   +1 more source

Rare variants in the melanocortin 4 receptor gene (MC4R) are associated with abdominal fat and insulin resistance in youth with obesity. [PDF]

Int J Obes (Lond)
Galuppo B, Mannam P, Bonet J, Pierpont B, Trico' D, Haskell-Luevano C, Ericson MD, Freeman KT, Philbrick WM, Bale AE, Caprio S, Santoro N.   +11 more
europepmc   +1 more source

Sex differences in weight gain, blood pressure control, and responses to melanocortin-4 receptor antagonism in offspring from lean and obese parents.

Am J Physiol Regul Integr Comp Physiol, 2023
do Carmo JM, Dai X, Aitken N, Larson KM, Omoto ACM, Gulke RR, Wang Z, Li X, Mouton AJ, Hall JE, da Silva AA.   +10 more
europepmc   +1 more source

Melanocortin 4 Receptor-Dependent Mechanism of ACTH in Preventing Anxiety-Like Behaviors and Normalizing Astrocyte Proteins after Early Life Seizures. [PDF]

eNeuro
Khalife MR, Villarin C, Ruiz JM, McClelland SA, Rabbo KA, Matthew Mahoney J, Scott RC, Hernan AE.   +7 more
europepmc   +1 more source

Melanocortin-4 Receptor PLC Activation Is Modulated by an Interaction with the Monocarboxylate Transporter 8. [PDF]

Int J Mol Sci
Anthofer L, Gmach P, Uretmen Kagiali ZC, Kleinau G, Rotter J, Opitz R, Scheerer P, Beck-Sickinger AG, Wolf P, Biebermann H, Bechmann I, Kühnen P, Krude H, Paisdzior S.   +13 more
europepmc   +1 more source

The melanocortin-4 receptor pathway and the emergence of precision medicine in obesity management. [PDF]

Diabetes Obes Metab
Fansa S, Acosta A.
europepmc   +1 more source

Setmelanotide: A Melanocortin-4 Receptor Agonist for the Treatment of Severe Obesity Due to Hypothalamic Dysfunction. [PDF]

touchREV Endocrinol
Qamar S, Mallik R, Makaronidis J.
europepmc   +1 more source

Case report: Nerve fiber regeneration in children with melanocortin 4 receptor gene mutation related obesity treated with semaglutide. [PDF]

Front Endocrinol (Lausanne)
Gad H, Mohammed I, Dauleh H, Pasha M, Al-Barazenji T, Hussain K, Malik RA.   +6 more
europepmc   +1 more source