Results 221 to 230 of about 60,692 (262)

Melanocortin‐1 receptor structure and functional regulation

Pigment Cell Research, 2005
SummaryThe melanogenic actions of the melanocortins are mediated by the melanocortin‐1 receptor (MC1R). MC1R is a member of the G‐protein‐coupled receptors (GPCR) superfamily expressed in cutaneous and hair follicle melanocytes. Activation of MC1R by adrenocorticotrophin or α‐melanocyte stimulating hormone is positively coupled to the cAMP signaling ...
José C, García-Borrón, Berta L, Sánchez-Laorden, Celia, Jiménez-Cervantes   +2 more
openaire   +2 more sources

Regulatory elements of the melanocortin 1 receptor

Peptides, 2005
Among more than 120 genes that are now known to regulate mammalian pigmentation, one of the key genes is MC1R, which encodes the melanocortin 1 receptor, a seven transmembrane G protein-coupled receptor expressed on the surface of melanocytes. Since the monoexonic sequence of the gene was cloned and characterized more than a decade ago, tremendous ...
Francois, Rouzaud, Vincent J, Hearing
openaire   +2 more sources

The Melanocortin‐1 Receptor and Human Pigmentation

Annals of the New York Academy of Sciences, 1999
ABSTRACT: α‐Melanocyte stimulating hormone (α‐MSH) is known to be the main physiologic regulator for integumental pigmentation of various vertebrate species. However, the role of α‐MSH and related melanocortins in the regulation of human cutaneous pigmentation is only beginning to be understood.
Z, Abdel-Malek, I, Suzuki, A, Tada, S, Im, C, Akcali   +4 more
openaire   +2 more sources

Melanocortins and the melanocortin 1 receptor, moving translationally towards melanoma prevention

Archives of Biochemistry and Biophysics, 2014
Beginning in the last decade of the twentieth century, the fields of pigment cell research and melanoma have witnessed major breakthroughs in the understanding of the role of melanocortins in human pigmentation and the DNA damage response of human melanocytes to solar ultraviolet radiation (UV).
Zalfa A, Abdel-Malek, Viki B, Swope, Renny J, Starner, Leonid, Koikov, Pamela, Cassidy, Sancy, Leachman   +5 more
openaire   +2 more sources

The Melanocortin-1 Receptor

2000
The melanocyte-stimulating hormone (MSH) receptor, recently renamed the melanocortin-1 receptor (MC1-R), is a 7 transmembrane domain receptor in the rhodopsin superfamily that plays an important role in the regulation of mammalian pigmentation. The study of the MC 1-R has introduced at least two novel paradigms to the G protein signaling field ...
Dongsi Lu, Carrie Haskell-Luevano, Dag Inge Vage, Roger D. Cone   +3 more
openaire   +1 more source

Melanocortin 1 receptor variation in the domestic dog

Mammalian Genome, 2000
The melanocortin 1 receptor (Mc1r) is encoded by the Extension locus in many different mammals, where a loss-of-function causes exclusive production of red/yellow pheomelanin, and a constitutively activating mutation causes exclusive production of black/brown eumelanin. In the domestic dog, breeds with a wild-type E allele, e.
J M, Newton, A L, Wilkie, L, He, S A, Jordan, D L, Metallinos, N G, Holmes, I J, Jackson, G S, Barsh   +7 more
openaire   +2 more sources

Genetic Studies of the Human Melanocortin‐1 Receptor

Annals of the New York Academy of Sciences, 1999
ABSTRACT: Genetic approaches have suggested a critical role for the melanocortin‐1 receptor in the control of pigmentation. We showed that this gene is unusually polymorphic in European populations and that, of the many variants, three in particular appear to be associated with red hair or fair skin.
J L, Rees, M, Birch-Machin, N, Flanagan, E, Healy, S, Phillips, C, Todd   +5 more
openaire   +2 more sources

The Human Melanocortin-1 Receptor

2000
One of the more obvious features that distinguishes one human from another are the pigmentatory characteristics (including skin type, hair and eye color) of the individual. Although it had been suspected (as a result of investigations into murine coat color) that several genes were likely to be involved in human pigmentation, and, although it had been ...
Eugene Healy, Mark Birch-Machin, Jonathan L. Rees   +2 more
openaire   +1 more source

Expression of Functional Melanocortin 1 Receptors in Insect Cells

Biochemical and Biophysical Research Communications, 1996
We expressed epitope-tagged human melanocortin 1 receptor (MC1R) in insect cells using two different recombinant baculovirus constructs; one of which encoded MC1R with an N-terminal Flag epitope and a C-terminal polyHis tag, while the other encoded the MC1R with a C-terminal Myc tag. The constructs were used to infect Sf9 insect cells.
Schiöth, Helgi, Kuusinen, Arja, Muceniece, Ruta, Szardenings, Michael, Keinänen, Kari, Wikberg, Jarl   +6 more
openaire   +3 more sources

Regulation of melanocortin-1 receptor pharmacology by melanocortin receptor accessory protein 2 in orange-spotted grouper (Epinephelus coioides)

General and Comparative Endocrinology, 2020
Melanocortin-1 receptor (MC1R) has important roles in regulating pigmentation and inflammation. Melanocortin receptor accessory protein 2 (MRAP2) modulates trafficking, ligand binding, and signaling of mammalian melanocortin receptors. However, the effect of MRAP2 on fish MC1R has not been extensively studied.
Li-Qin, Ji, Ying-Zhu, Rao, Yong, Zhang, Rong, Chen, Ya-Xiong, Tao   +4 more
openaire   +2 more sources