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Expression of melanocortin 1 receptor in periaqueductal gray matter
NeuroReport, 1995The localization of the melanocortin 1 (MC1) receptor in brain was investigated by in situ hybridization and immunohistochemistry. In rat periaqueductal gray matter (PAG), a small number of cells which displayed a punctate distribution showed a specific hybridization signal for MC1 receptor mRNA, whereas other regions studied were negative.
Y, Xia, J E, Wikberg, V, Chhajlani
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Mechanism of dimerization of the human melanocortin 1 receptor
Biochemical and Biophysical Research Communications, 2008The melanocortin 1 receptor (MC1R) is a dimeric G protein-coupled receptor expressed in melanocytes, where it regulates the amount and type of melanins produced and determines the tanning response to ultraviolet radiation. We have studied the mechanisms of MC1R dimerization.
Paola T, Zanna +6 more
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Evolutionary Genetics of the Melanocortin‐1 Receptor in Vertebrates
Annals of the New York Academy of Sciences, 2003Abstract: The molecular genetic basis of adaptive change in phenotype is a major outstanding issue in evolutionary biology. Evolutionary change in coat and plumage color is a promising system for making progress in this field. Most notably, recent work on the molecular genetic basis of hair and feather color has identified several genes which are ...
Nicholas I, Mundy +3 more
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Melanocortin-1 receptor (MC1R): a review for dermatologists
Italian Journal of Dermatology and VenereologyMelanocortin-1 receptor (MC1R) and its variants have a pivotal role in melanin synthesis. However, MC1R has been associated to non-pigmentary pathways related to DNA-repair activities and inflammation. The aim of this review is to provide an up-to-date overview about the role of MC1R in the skin.
Guida S. +9 more
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Novel Agouti-Related-Protein-Based Melanocortin-1 Receptor Antagonist
Journal of Medicinal Chemistry, 2001The melanocortin receptors are G-protein coupled receptors (GPCRs) that activate the cAMP signal transduction pathway and are stimulated by the melanocortin agonist alpha-melanocyte stimulating hormone (alpha-MSH). Members of these melanocortin receptors are antagonized by agouti (ASP) and agouti-related protein (AGRP), which are the only known ...
R, Thirumoorthy +5 more
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A Melanocortin 1 Receptor Allele Suggests Varying Pigmentation Among Neanderthals
Science, 2007The melanocortin 1 receptor (MC1R) regulates pigmentation in humans and other vertebrates. Variants of MC1R with reduced function are associated with pale skin color and red hair in humans of primarily European origin. We amplified and sequenced a fragment of the MC1R gene ( mc1r ) from two Neanderthal remains. Both
C. CLALUEZA FOX +16 more
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Melanocortin 1 receptor variants, pigmentation, and skin cancer susceptibility
Photodermatology, Photoimmunology & Photomedicine, 2004The melanocortin 1 receptor is a key regulator of variation in normal human pigmentation. Genetic variants of this receptor cause red hair and fair skin, and several case–control studies have demonstrated that these genetic variants increase the risk of skin cancer development in humans.
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[Genotype, melanocortin 1 receptor and ultraviolet radiation].
Yi chuan = Hereditas, 2005Recent work on the melanocortin 1 receptor (MC1R) suggests that MC1R plays a central role in regulation of eumelanin (brown/black melanins) and phaeomelanin (red/yellow melanins) synthesis within the mammalian melanocyte. In the mouse,genetic studies show that the MC1R appears to be a unique, bifunctionally controlled receptor, activated by alpha-MSH ...
Xue-mei, Lü, Peng, Shi, Ya-ping, Zhang
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