Results 191 to 200 of about 60,346 (220)
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General and Comparative Endocrinology, 2019
The melanocortin-4 receptor (MC4R) acts as a member of G-protein coupled receptors and participate in food intake and energy expenditure. Melanocortin 2 receptor accessory protein 2 (MRAP2) plays a critical role in regulating MC4R signaling in mammals and zebrafish. However, evidence on their interaction in other teleost species remains elusive.
Meng, Wang +6 more
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The melanocortin-4 receptor (MC4R) acts as a member of G-protein coupled receptors and participate in food intake and energy expenditure. Melanocortin 2 receptor accessory protein 2 (MRAP2) plays a critical role in regulating MC4R signaling in mammals and zebrafish. However, evidence on their interaction in other teleost species remains elusive.
Meng, Wang +6 more
openaire +2 more sources
The Journal of Pharmacology and Experimental Therapeutics, 1999
Melanocortin peptides are known to be extremely potent in causing the sustained reversal of different shock conditions, both in experimental animals and humans; the mechanism of action includes an essential brain loop. Three melanocortin receptor subtypes are expressed in brain tissue: MC(3), MC(4,) and MC(5) receptors.
GUARINI, Salvatore +8 more
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Melanocortin peptides are known to be extremely potent in causing the sustained reversal of different shock conditions, both in experimental animals and humans; the mechanism of action includes an essential brain loop. Three melanocortin receptor subtypes are expressed in brain tissue: MC(3), MC(4,) and MC(5) receptors.
GUARINI, Salvatore +8 more
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Melanocortin 4 Receptor (MC4R) Deficiency
2018An 18-year-old female student comes for an evaluation, accompanied by her parents. She has been considering bariatric surgery to manage her long-standing history of obesity. The patient reports that since early childhood, she has had “weight issues.” Her parents remember that at 12 months of age, she was always hungry and constantly seeking food.
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Characterisation of the Melanocortin 4 Receptor by Radioligand Binding
Pharmacology & Toxicology, 1996Abstract: The DNA encoding the human melanocortin 4 receptor was expressed in COS (CV‐1 origin, SV 40) cells and its radioligand binding properties was tested by using the [125I][Nle4, D‐Phe7]α‐melanocyte stimulating hormone (MSH). The radioligand was found to bind to a single saturable site with a Kd of 3.84±0.57 nmol/1 in the MC4 receptor expressing
H B, Schiöth +2 more
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Small Molecule Ligands of the Human Melanocortin-4 Receptor
Current Topics in Medicinal Chemistry, 2007Genetic and pharmacological studies, involving both animals and humans, suggest that the central MC4 receptor plays a key role in homeostatic control, most probably via regulation of appetite and energy expenditure. This has stimulated intense research efforts in the field of drug discovery to identify MC4 receptor agonists and antagonists for the ...
Feroze, Ujjainwalla, Iyassu K, Sebhat
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The genetic epidemiology of melanocortin 4 receptor variants
European Journal of Pharmacology, 2011While rare MC4R mutations are the commonest cause of monogenic forms of extreme, early-onset obesity, growing evidence shows that common MC4R variants contribute to obesity in the general population. Candidate gene studies have focussed on the V103I and I251L MC4R variants that both affect MC(4) receptor function in vitro.
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Melanocortin 4 receptors interact with antimicrobial frog peptide analogues
Biochemical and Biophysical Research Communications, 2006We have developed fluorescence polarization (FP) assays of human melanocortin 4 receptor (MC4R) in 384-well microtiter plates using TAMRA-NDP-MSH as a tracer. The rank order of potency of agonists and antagonists agrees well relative to the published assays: SHU9119>MTII>NDP alphaMSH>alphaMSH.
Ernest U, Do +10 more
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Melanocortin-4 Receptor in Energy Homeostasis and Obesity Pathogenesis
2013The melanocortin-4 receptor gene (MC4R) has intensively been analyzed in molecular genetic obesity research. Decreased MC4R activity leads to obesity. Currently 166 nonsynonymous, nonsense, deletion, and frameshift MC4R mutations have been described. Vast numbers of these mutations were identified in (extremely) obese individuals. Total or partial loss
Hinney, Anke +2 more
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[Obesity caused by melanocortin-4 receptor mutations].
Nederlands tijdschrift voor geneeskunde, 2012Obesity is usually the result of a combination of genetic and lifestyle factors. In monogenic obesity, overweight is caused by a single gene mutation. The most frequent form of monogenic obesity is caused by mutations in the gene that codes for the melanocortin-4 receptor (MC4R gene).
Linda, van den Berg +3 more
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