Results 21 to 30 of about 46,589 (229)

Incorporation of Indoylated Phenylalanine Yields a Sub-Micromolar Selective Melanocortin-4 Receptor Antagonist Tetrapeptide. [PDF]

ACS Omega, 2022
Ericson MD, Larson CM, Freeman KT, Nicke L, Geyer A, Haskell-Luevano C.   +5 more
europepmc   +2 more sources

The complicated clinical course in a case of atypical lipodystrophy after development of neutralizing antibody to metreleptin: treatment with setmelanotide

Endocrinology, Diabetes & Metabolism Case Reports, 2020
A patient with atypical partial lipodystrophy who had a transient initial response to metreleptin experienced acute worsening of her metabolic state when neutralizing antibodies against metreleptin appeared.
Baris Akinci, Rasimcan Meral, Diana Rus, Rita Hench, Adam H Neidert, Frank DiPaola, Maria Westerhoff, Simeon I Taylor, Elif A Oral   +8 more
doaj   +1 more source

MON-672 Role Of Ligand- And Genetic Variant Dependent Melanocortin 4 Receptor (mc4r) Bias Signaling For The Individual Risk To Develop Obesity [PDF]

J Endocr Soc
Lisa Rück, Patrick Scheerer, Sarah Paisdzior, Susanna Wiegand, Gunnar Kleinau, Nicolas Heyder, Philipp Gmach, Sabine Jyrch, Annette G. Beck‐Sickinger, Mark Troll, Heike Biebermann, Peter Kühnen   +11 more
europepmc   +3 more sources

Melanocortin-4 receptor–regulated energy homeostasis [PDF]

Nature Neuroscience, 2016
The melanocortin system provides a conceptual blueprint for the central control of energetic state. Defined by four principal molecular components--two antagonistically acting ligands and two cognate receptors--this phylogenetically conserved system serves as a prototype for hierarchical energy balance regulation.
Michael J, Krashes, Bradford B, Lowell, Alastair S, Garfield   +2 more
openaire   +2 more sources

Melanocortin Pathways: Suppressed and Stimulated Melanocortin-4 Receptor (MC4R)

Physiological Research, 2020
Leptin-melanocortin pathway plays an essential role in the body weight regulation. Enhanced melanocortin signaling in the hypothalamus results in both decreased food intake and increased energy expenditure. The discovery of monogenic obesities with dysfunction of melanocortin-4 receptor (MC4R) greatly contributed to understanding of energy balance ...
V, Hainer, I, Aldhoon Hainerová, M, Kunešová, R, Taxová Braunerová, H, Zamrazilová, B, Bendlová   +5 more
openaire   +2 more sources

Anti-Melanocortin-4 Receptor Autoantibodies in Obesity [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2009
The melanocortin-4 receptor (MC4R) is part of an important pathway regulating energy balance. Here we report the existence of autoantibodies (autoAbs) against the MC4R in sera of obese patients.The autoAbs were detected after screening of 216 patients' sera by using direct and inhibition ELISA with an N-terminal sequence of the MC4R.
Peter, J. C., Bekel, A., Lecourt, A. C., Zipfel, G., Eftekhari, P., Nesslinger, M., Breidert, M., Muller, S., Kessler, L., Hofbauer, K. G.   +9 more
openaire   +4 more sources

The melanocortin pathway and energy homeostasis: From discovery to obesity therapy

Molecular Metabolism, 2021
Background: Over the past 20 years, insights from human and mouse genetics have illuminated the central role of the brain leptin-melanocortin pathway in controlling mammalian food intake, with genetic disruption resulting in extreme obesity, and more ...
Giles S.H. Yeo, Daniela Herrera Moro Chao, Anna-Maria Siegert, Zoe M. Koerperich, Mark D. Ericson, Stephanie E. Simonds, Courtney M. Larson, Serge Luquet, Iain Clarke, Shubh Sharma, Karine Clément, Michael A. Cowley, Carrie Haskell-Luevano, Lex Van Der Ploeg, Roger A.H. Adan   +14 more
doaj   +1 more source

Melanocortin 4 Receptor Becomes an ACTH Receptor by Coexpression of Melanocortin Receptor Accessory Protein 2 [PDF]

Molecular Endocrinology, 2013
Melanocortin 2 receptor (MC2R) is the only canonical ACTH receptor. Its functional expression requires the presence of an accessory protein, known as melanocortin receptor 2 accessory protein 1 (MRAP1). The vertebrate genome exhibits a paralogue gene called MRAP2, which is duplicated in zebrafish (MRAP2a and MRAP2b), although its function remains ...
Agulleiro Gozalbo, Maria Josep, Cortés, Raúl, Fernández-Durán, Begoña, Navarro, Sandra, Guillot, Raúl, Meimaridou, E., Clark, A. J. L., Cerdá-Reverter, José Miguel   +7 more
openaire   +3 more sources

The melanocortin action is biased toward protection from weight loss in mice

Nature Communications, 2023
The melanocortin action is well perceived for its ability to regulate body weight bidirectionally with its gain of function reducing body weight and loss of function promoting obesity.
Hongli Li, Yuanzhong Xu, Yanyan Jiang, Zhiying Jiang, Joshua Otiz-Guzman, Jessie C. Morrill, Jing Cai, Zhengmei Mao, Yong Xu, Benjamin R. Arenkiel, Cheng Huang, Qingchun Tong   +11 more
doaj   +1 more source

The effect of human wharton’s jelly-derived mesenchymal stem cells on MC4R, NPY, and LEPR gene expression levels in rats with streptozotocin-induced diabetes [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): Type 1 diabetes (T1D) is an autoimmune disease resulting from inflammatory destruction of islets β-cells. Nowadays, progress in cell therapy, especially mesenchymal stem cells (MSCs) proposes numerous potential remedies for T1D. We aimed to
Fatemeh Sabet Sarvestani, Mohammad Ali Zare, Forough saki, Farhad Koohpeyma, Ismail H. al-Abdullah, Negar Azarpira   +5 more
doaj   +1 more source