Pharmacological modulation of the cAMP signaling of two isoforms of melanocortin-3 receptor by melanocortin receptor accessory proteins in the tetrapod Xenopus laevis [PDF]
Endocrine Connections, 2021 As a member of the seven-transmembrane rhodopsin-like G protein-coupled receptor superfamily, the melanocortin-3 receptor (MC3R) is vital for the regulation of energy homeostasis and rhythms synchronizing in mammals, and its pharm acological effect could
Ying Xu +12 more
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The melanocortin receptor genes are linked to and associated with the risk of polycystic ovary syndrome in Italian families [PDF]
Journal of Ovarian ResearchPolycystic ovary syndrome (PCOS) is the most common endocrine disorder occurring in women of reproductive age. The disease is caused by a complex interplay of genetic and environmental factors including genes encoding components of the hypothalamic ...
Rongling Wu, Claudia Gragnoli
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Melanocortin receptor accessory proteins in adrenal disease and obesity [PDF]
Frontiers in Neuroscience, 2015 Melanocortin receptor accessory proteins (MRAPs) are regulators of the melanocortin receptor family. MRAP is an essential accessory factor for the functional expression of the MC2R/ACTH receptor.
David eJackson +3 more
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Observations on the evolution of the melanocortin receptor gene family: distinctive features of the melanocortin-2 receptor [PDF]
Frontiers in Neuroscience, 2013 The melanocortin receptors are a gene family in the rhodopsin class of G protein-coupled receptors. Based on the analysis of several metazoan genome databases it appears that the melanocortin receptors are only found in chordates.
Robert Michael Dores
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Development of a genetically encoded melanocortin sensor for high sensitivity in vivo imaging [PDF]
Molecular MetabolismObjective: The central melanocortin system, composed of peptides derived from pro-opiomelanocortin (POMC) such as the melanocyte-stimulating hormones (α-, β-, γ-MSH) and melanocortin 4 receptors (MC4R), along with the agouti-related protein (AgRP), plays
Yoon Namkung +6 more
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Oxytocin neurons drive melanocortin circuit maturation via vesicle release during a neonatal critical period. [PDF]
PLoS BiologyThe hypothalamus is crucial for regulating essential bodily functions, including energy balance. It is an exceedingly complex and heterogeneous brain region that contains a variety of neuronal systems that are interconnected with each other. Among these,
Pierre-Yves Barelle +7 more
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ARPE-19-derived VEGF-containing exosomes promote neovascularization in HUVEC: the role of the melanocortin receptor 5. [PDF]
Cell Cycle, 2019 Maisto R +9 more
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Biomolecules, 2022 The neural melanocortin receptors (MCRs), melanocortin-3 and -4 receptors (MC3R and MC4R), play essential non-redundant roles in the regulation of energy homeostasis. Interaction of neural MCRs and melanocortin-2 receptor accessory proteins (MRAPs, MRAP1
Ren-Lei Ji, Ya-Xiong Tao
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The neuropeptide alpha-melanocyte-stimulating hormone is critically involved in the development of cytotoxic CD8+ T cells in mice and humans. [PDF]
PLoS ONE, 2010 BACKGROUND: The neuropeptide alpha-melanocyte-stimulating hormone is well known as a mediator of skin pigmentation. More recently, it has been shown that alpha-melanocyte-stimulating hormone also plays pivotal roles in energy homeostasis, sexual function,
Karin Loser +10 more
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Melanocortin System in Kidney Homeostasis and Disease: Novel Therapeutic Opportunities
Frontiers in Physiology, 2021 Melanocortin peptides, melanocortin receptors, melanocortin receptor accessory proteins, and endogenous antagonists of melanocortin receptors are the key components constituting the melanocortin hormone system, one of the most complex and important ...
Mingyang Chang +4 more
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