Results 131 to 140 of about 44,230 (269)

Npy deletion in an alcohol non-preferring rat model elicits differential effects on alcohol consumption and body weight. [PDF]

open access: yes, 2016
Neuropeptide Y (NPY) is widely expressed in the central nervous system and influences many physiological processes. It is located within the rat quantitative trait locus (QTL) for alcohol preference on chromosome 4.
Bell, Richard L.   +8 more
core   +1 more source

Genetic Legacy of the Last Ice Age Shapes Shallow Phylogeographic Structure in a Widespread Mediterranean Snake

open access: yesJournal of Biogeography, Volume 53, Issue 4, April 2026.
ABSTRACT Aim Mediterranean peninsulas typically harbour high intraspecific genetic diversity associated with long‐term persistence in multiple glacial refugia. However, some widespread taxa show unexpectedly shallow phylogeographic structure. Here, we investigate which historical processes can generate a pattern of strong genetic depletion within a ...
Daniele Salvi   +5 more
wiley   +1 more source

Pharmacogenomic and structural analysis of constitutive G-protein coupled receptor activity [PDF]

open access: yes, 2007
Premi a l'excel·lència investigadora. Àmbit de les Ciències de la Salut. 2008G-protein coupled receptors (GPCRs) respond to a chemically diverse plethora of signal transduction molecules.
Aldo Jongejan   +29 more
core   +3 more sources

Noradrenergic inhibition of definitive POMC neurons through direct and indirect mechanisms

open access: yesJournal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Norepinephrine and the α2‐adrenoceptor agonist UK 14,304 robustly inhibit definitive arcuate POMC neurons. Direct inhibition is mediated by ADRA2A‐dependent activation of potassium conductances, while additional indirect mechanisms also contribute. In vivo, inducible POMC‐specific Adra2a deletion minimally affects energy balance and modestly impairs ...
Olivier Lavoie   +6 more
wiley   +1 more source

Amplification of the Melanocortin-1 Receptor in Nephrotic Syndrome Identifies a Target for Podocyte Cytoskeleton Stabilization [PDF]

open access: gold, 2018
Lovisa Bergwall   +10 more
openalex   +1 more source

Retinal ganglion cell degeneration in glaucoma disrupts HPA axis temporal organization and dampens corticosterone production

open access: yesJournal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Abstract Glaucoma is a chronic optic neuropathy characterized by progressive vision loss. A previous study from our group showed that glaucoma‐induced retinal degeneration disrupts photic signaling to the suprachiasmatic nucleus (SCN), altering the molecular components of the central circadian clock.
Pietra Souza Barsanele   +7 more
wiley   +1 more source

Aged Brains Express Less Melanocortin Receptors, Which Correlates with Age-Related Decline of Cognitive Functions. [PDF]

open access: yesMolecules, 2021
Zhou Y   +7 more
europepmc   +1 more source

Skin‐Lightening Efficacy of Leatherleaf Fern Extract and a Leatherleaf Fern‐Based Facial Serum In Vitro and Clinical Trial

open access: yesJournal of Cosmetic Dermatology, Volume 25, Issue 4, April 2026.
ABSTRACT Background Hyperpigmentation, caused by excessive melanin accumulation, is a significant cosmetic concern in dermatology. Natural compounds are receiving attention as safe and effective skin‐lightening agents due to their antioxidant properties and ability to inhibit melanin synthesis.
Jung‐Wook Kang   +4 more
wiley   +1 more source

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