Results 231 to 240 of about 44,230 (269)

Evolution of melanocortin receptors in teleost fish: The melanocortin type 1 receptor

Gene, 2007
The melanocortin type 1 receptor (Mc1r) belongs to a family of G-protein-coupled receptors involved in various physiological processes in vertebrates. Melanocortins, the Mcr natural agonists, are pituitary peptide hormones including adrenocorticotropin and melanocyte-stimulating hormones.
Yvonne, Selz, Ingo, Braasch, Carsten, Hoffmann, Cornelia, Schmidt, Christina, Schultheis, Manfred, Schartl, Jean-Nicolas, Volff   +6 more
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Molecular Modeling of Melanocortin Receptors

Current Topics in Medicinal Chemistry, 2007
Molecular modeling of G-protein coupled receptors (GPCRs) remains a challenge due to the limited availability of structural information for the receptors. Molecular modeling approaches for melanocortin receptors (MCRs) fall into three categories: structure-based, ligand-based, and proteochemometric.
Hongmao, Sun, David, Fry
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Melanocortin receptors weigh in

Nature Medicine, 2004
Well over ten years ago, hints begin to emerge that the melanocortin system, implicated in adrenal function and skin pigmentation, might also regulate energy balance. In the 1990s, speculation gave way to hard data: a melanocortin receptor highly expressed in the brain was firmly established as a central regulator of food intake and fat mass.
Stephen O'Rahilly, Giles S H Yeo, I Sadaf Farooqi   +2 more
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The Melanocortin Receptors

2000
Part I: Historical Perspectives. Proopiomelanocortin and the Melanocortin Peptides, A. N. Eberle. Melanocortins and Pigmentation, A. B. Lerner. Melanocortins and Adrenocortical Function, M. Begeot and J. M. Saez. Effects of Melanocortins in the Nervous System, R. A. H. Adan. Peripheral Effects of Melanocortins, B. A. Boston. Part II.
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Melanocortin 3 receptor gene and melanocortin 4 receptor gene mutations: the Asian Perspective

Diabetes/Metabolism Research and Reviews, 2012
SummaryMelanocortin 4 receptor (MC4R) deficiency resulting from disruption of one or both MC4R alleles represents the commonest monogenic form of human obesity to date. Human MC4R deficiency was reported to affect 4 and 5.8% of severely obese French and British populations respectively.
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Melanocortin Receptors: Ligands and Proteochemometrics Modeling

Annals of the New York Academy of Sciences, 2003
Abstract: The melanocortin receptors exist in five subtypes, MC1–5R. These receptors participate in important regulations of the immune system, central behavior, and endocrine and exocrine glands. Here we provide a short review on MCR subtype selective peptides and organic compounds with activity on the MCRs, developed in our laboratory. Also provided
J E S, Wikberg, F, Mutulis, I, Mutule, S, Veiksina, M, Lapinsh, R, Petrovska, P, Prusis   +6 more
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Melanocortin-4 receptor mutations in obesity.

Advances in clinical chemistry, 2009
The current alarming spread of obesity in many parts of the world is caused by a sudden environmental shift characterized by replacement of a frugal diet with low cost, energy dense food, and little requests for physical activity during work and leisure time.
SANTINI, FERRUCCIO, MAFFEI M, PELOSINI, CATERINA, SALVETTI G, SCARTABELLI G, PINCHERA, ALDO   +5 more
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The Melanocortin-1 Receptor

Archives of Dermatology, 2001
Although human pigmentation is genetically complex, to date polymorphism at only 1 locus, the melanocortin-1 receptor (MC1-R), has been associated with physiologic variation in hair and skin color. The MC1-R, a G protein-coupled receptor with 7 transmembrane-spanning domains, plays a key role in determining the type of melanin (eumelanin vs pheomelanin)
J V, Schaffer, J L, Bolognia
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Melanocortins in Brain Inflammation: The Role of Melanocortin Receptor Subtypes

2010
The melanocortins (MC) are released from neurons and paracrine cells in the CNS where they are involved in important physiological functions, including regulation of body temperature and immune responses. MC bind to melanocortin receptors, a class of cell surface G-protein-coupled receptors. Of the five subtypes of MC receptors that have been cloned in
Ruta, Muceniece, Maija, Dambrova
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Chapter 12 Melanocortin receptors

1997
Publisher Summary Pro-opiomelanocortin (POMC) is expressed in the brain as well as the pituitary and is the precursor for melanocortin peptides, adrenocorticotropin, melanocyte-stimulating hormone, and fragments thereof. In addition to their well-known effects on pigmentation and steroidogenesis, melanocortin peptides have numerous activities in the ...
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