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2000
The melanocyte-stimulating hormone (MSH) receptor, recently renamed the melanocortin-1 receptor (MC1-R), is a 7 transmembrane domain receptor in the rhodopsin superfamily that plays an important role in the regulation of mammalian pigmentation. The study of the MC 1-R has introduced at least two novel paradigms to the G protein signaling field ...
Dongsi Lu +3 more
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The melanocyte-stimulating hormone (MSH) receptor, recently renamed the melanocortin-1 receptor (MC1-R), is a 7 transmembrane domain receptor in the rhodopsin superfamily that plays an important role in the regulation of mammalian pigmentation. The study of the MC 1-R has introduced at least two novel paradigms to the G protein signaling field ...
Dongsi Lu +3 more
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2000
After cloning of the melanocyte MC1-R (1,2) and adrenocortical MC2-R (2),interest in the possibility of unique neural homologs of these receptors grew from observations of central effects of melanocortins, such as effects on learning and memory (reviewed in ref. 3) and temperature control (4).
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After cloning of the melanocyte MC1-R (1,2) and adrenocortical MC2-R (2),interest in the possibility of unique neural homologs of these receptors grew from observations of central effects of melanocortins, such as effects on learning and memory (reviewed in ref. 3) and temperature control (4).
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2000
Melanocortins are a subset of peptides derived from the proopiomelanocortin (POMC) gene product, including ACTH, α-, β-, and γ-MSH (1,2). The name refers to the two principal activities of these peptides, that is, regulation of pigmentation in skin and hair and steroidogenesis in the adrenal cortex.
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Melanocortins are a subset of peptides derived from the proopiomelanocortin (POMC) gene product, including ACTH, α-, β-, and γ-MSH (1,2). The name refers to the two principal activities of these peptides, that is, regulation of pigmentation in skin and hair and steroidogenesis in the adrenal cortex.
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2000
This chapter deals with perhaps the least understood receptor for the melanocortin peptides, that is the melanocortin-3 receptor (MC3-R). Although naturally occurring and genetically engineered mutations have provided us with insight into the function of the other known melanocortin receptors, little is known about the physiologic role of the MC3-R ...
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This chapter deals with perhaps the least understood receptor for the melanocortin peptides, that is the melanocortin-3 receptor (MC3-R). Although naturally occurring and genetically engineered mutations have provided us with insight into the function of the other known melanocortin receptors, little is known about the physiologic role of the MC3-R ...
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Melanocortin 4 Receptors Reciprocally Regulate Sympathetic and Parasympathetic Preganglionic Neurons
Cell, 2013Jong-Woo Sohn, Bradford Lowell
exaly