Results 171 to 180 of about 3,506 (222)

A mammalian tripartite enhancer cluster controls hypothalamic Pomc expression, food intake, and body weight. [PDF]

open access: yesProc Natl Acad Sci U S A
Rojo D   +6 more
europepmc   +1 more source
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Brain effects of melanocortins☆

Pharmacological Research, 2009
The melanocortins (alpha, beta and gamma-melanocyte-stimulating hormones: MSHs; adrenocorticotrophic hormone: ACTH), a family of pro-opiomelanocortin (POMC)-derived peptides having in common the tetrapeptide sequence His-Phe-Arg-Trp, have progressively revealed an incredibly wide range of extra-hormonal effects, so to become one of the most promising ...
Anna Valeria Vergoni
exaly   +3 more sources

Melanocortins and feeding behavior

open access: yesBiomedicine and Pharmacotherapy, 2000
The melanocortin (ACTH/MSH) peptides exert a number of central effects. In the eighties, we described for the first time a role for melanocortins in the central control of appetite. We showed that the injection of ACTH-(1-24) into a brain lateral ventricle reduced food intake up to 76.6% in starved rats.
Helgi Birgir Schiöth
exaly   +3 more sources

The melanocortin system

American Journal of Physiology-Endocrinology and Metabolism, 2003
The melanocortin system consists of melanocortin peptides derived from the proopiomelanocortin gene, five melanocortin receptors, two endogenous antagonists, and two ancillary proteins. This review provides an abbreviated account of the basic biochemistry, pharmacology, and physiology of the melanocortin system and highlights progress made in four ...
Ira, Gantz, Tung M, Fong
openaire   +2 more sources

Melanocortins and reproduction

Brain Research Reviews, 2002
Obesity, anorexia and general body weight fluctuations cause a variety of effects on the reproductive system. Our understanding of the neuro-biological mechanisms of the connections between body weight and the reproductive axis is not especially developed despite a number of interesting physiological observations.
Helgi B, Schiöth, Hajime, Watanobe
openaire   +2 more sources

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