Results 1 to 10 of about 4,461 (146)

Cloning, distribution, and effects of growth regulation of MC3R and MC4R in red crucian carp (Carassius auratus red var.) [PDF]

Frontiers in Endocrinology, 2023
BackgroundMelanocortin-3 and -4 receptors (MC3R and MC4R), G protein-coupled receptors, play vital roles in the regulation of energy homeostasis. To understand the functions of mc3r and mc4r in the energy homeostasis of red crucian carp (Carassius ...
Min Tao
exaly   +4 more sources

Cross-species studies implicate the melanocortin 3 receptor more strongly in the control of pubertal development than energy balance [PDF]

Molecular Metabolism
Hypothalamic neurons expressing either POMC or AGRP sense nutritional state directly and indirectly and transmit these neuropeptide signals to other brain centres through the melanocortin 3 and 4 receptors. MC4R is primarily concerned with the control of
Katie Duckett, Alyce McClellan, Laura J. Corbin, Irene Cimino, Ahmed Elhakeem, Ana Goncalves Soares, Alice Williamson, Eloise Cross, Zammy Fairhurst-Hunter, Slavé Petrovski, Debra Rimmington, Jesús Alegre-Díaz, Jaime Berumen, Pablo Kuri-Morales, Roberto Tapia-Conyer, Jacek Mokrosinski, I. Sadaf Farooqi, Asif Rasheed, Danish Saleheen, Adam S. Butterworth, Nicholas J. Timpson, Anthony P. Coll, Eleanor Raffan, Brian Y.H. Lam, Stephen O’Rahilly   +24 more
doaj   +2 more sources

Melanocortin 3 receptor regulates hepatic autophagy and systemic adiposity [PDF]

Nature Communications
Systemic lipid homeostasis requires hepatic autophagy, a major cellular program for intracellular fat recycling. Here, we find melanocortin 3 receptor (MC3R) regulates hepatic autophagy in addition to its previously established CNS role in systemic ...
Tushar P. Patel, Joo Yun Jun, Arnold Y. Seo, Noah J. Levi, Diana M. Elizondo, Jocelyn Chen, Adrian M. Wong, Nicol Tugarinov, Elizabeth K. Altman, Daniel B. Gehle, Sun Min Jung, Pooja Patel, Mark Ericson, Carrie Haskell-Luevano, Tamar C. Demby, Antony Cougnoux, Anna Wolska, Jack A. Yanovski   +17 more
doaj   +2 more sources

Pro-Opiomelanocortin and Melanocortin Receptor 3 and 4 Mutations in Genetic Obesity [PDF]

Biomolecules
Genetic obesity results from loss-of-function mutations, including those affecting the leptin–melanocortin system, which regulates body weight. Pro-opiomelanocortin (POMC)-derived neurohormones act as ligands for melanocortin receptors (MCRs), regulating
Tulin Yanik, Seyda Tugce Durhan
doaj   +2 more sources

Allelic variants of melanocortin 3 receptor gene (MC3R) and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets. [PDF]

PLoS ONE, 2011
INTRODUCTION: The melanocortin system plays an important role in energy homeostasis. Mice genetically deficient in the melanocortin-3 receptor gene have a normal body weight with increased body fat, mild hypophagia compared to wild-type mice.
José L Santos, Rolando De la Cruz, Claus Holst, Katrine Grau, Carolina Naranjo, Alberto Maiz, Arne Astrup, Wim H M Saris, Ian MacDonald, Jean-Michel Oppert, Torben Hansen, Oluf Pedersen, Thorkild I A Sorensen, J Alfredo Martinez, NUGENOB Consortium   +14 more
doaj   +3 more sources

Ring finger protein 11 inhibits melanocortin 3 and 4 receptor signaling [PDF]

Frontiers in Endocrinology, 2016
Intact melanocortin signaling via the G protein-coupled receptors (GPCRs) melanocortin receptor 4 (MC4R) and melanocortin receptor 3 (MC3R) is crucial for body weight maintenance.
Anne Müller, Lars Niederstadt, Wenke Jonas, Wenke Jonas, Chun-Xia Yi, Franziska Meyer, Petra Wiedmer, Jana Fischer, Carsten Grötzinger, Annette Schürmann, Annette Schürmann, Matthias Tschöp, Matthias Tschöp, Gunnar Kleinau, Annette Grüters, Heiko Krude, Heike Biebermann   +16 more
doaj   +4 more sources

Fasting-induced activity changes in MC3R neurons of the paraventricular nucleus of the thalamus [PDF]

Life Science Alliance
This study assesses how the brain responds to fasting and the role of melanocortin 3 receptor neurons within the paraventricular nucleus of the thalamus, measured using immunohistochemistry, microscopy, chemogenetics, and behavioral analysis.
Robert A Chesters, Jiajie Zhu, Bethany M Coull, David Baidoe-Ansah, Lea Baumer, Lydia Palm, Niklas Klinghammer, Seve Chen, Anneke Hahm, Selma Yagoub, Lídia Cantacorps, Daniel Bernardi, Katrin Ritter, Rachel N Lippert   +13 more
doaj   +2 more sources

A mouse model for a partially inactive obesity-associated human MC3R variant

Nature Communications, 2016
The melanocortin receptor, MC3R, regulates organismal energy homeostasis. Here, Lee et al. create knock-in mice with the a mutated version of the human MC3R receptor found in obese children, and show these mice have more fat and smaller bone, yet are by ...
Arnold Y Seo, Jack A Yanovski, Oksana Gavrilova   +2 more
exaly   +2 more sources

Cellular signatures of melanocortin pathway genes across the locus coeruleus [PDF]

Acta Neuropathologica Communications
Obesity and Alzheimer’s disease (AD) are epidemiologically associated. The locus coeruleus (LC)—the brain’s primary and most significant source of norepinephrine—is one of the earliest sites of neurodegeneration in AD.
Alisha Basak, Fahrünisa Meryem Betül Erol, Maria Caterina De Rosa, Zhangji Dong, Victor Ogbolu, Hannah J. Glover, Rick Rausch, Gunnar Hargus, Jordi Creus-Muncunill, Heather Buchanan, Yu Bai, Qi Su, Betty Chang, Christina Adler, Delaney Flaherty, Benjamin Ciener, Harrison Xiao, Hasini Reddy, Pascaline Aime-Wilson, Christiane Reitz, Mark W. Sleeman, Judith Y. Altarejos, Rudolph L. Leibel, Liang Oscar Qiang, Andrew F. Teich, Claudia A. Doege   +25 more
doaj   +2 more sources

Subthreshold activation of the melanocortin system causes generalized sensitization to anorectic agents in mice [PDF]

The Journal of Clinical Investigation
The melanocortin-3 receptor (MC3R) regulates GABA release from agouti-related protein (AgRP) nerve terminals and thus tonically suppresses multiple circuits involved in feeding behavior and energy homeostasis.
Naima S. Dahir, Yijun Gui, Yanan Wu, Patrick R. Sweeney, Alix A.J. Rouault, Savannah Y. Williams, Luis E. Gimenez, Tomi K. Sawyer, Stephen T. Joy, Anna K. Mapp, Roger D. Cone   +10 more
doaj   +2 more sources