Results 21 to 30 of about 4,530 (193)

Melanocortin receptor 3 and 4 mRNA expression in the adult female Syrian hamster brain

Frontiers in Molecular Neuroscience, 2023
Melanocortin 3 receptors (MC3R) and melanocortin 4 receptors (MC4R) are vital in regulating a variety of functions across many species. For example, the dysregulation of these receptors results in obesity and dysfunction in sexual behaviors.
Megan A. L. Hall, Abigail L. Kohut-Jackson, Anna C. Peyla, Gloria D. Friedman, Nicole J. Simco, Johnathan M. Borland, Robert L. Meisel   +6 more
doaj   +1 more source

LBODP080 Mc3r Expression In Liver Tissue Is Partially Responsible For The Severity Of Murine MC3R Deficiency Associated Obesity

Journal of the Endocrine Society, 2022
Abstract The Melanocortin 3 Receptor (MC3R) is highly expressed in the hypothalamus, where it regulates energy balance and pubertal development. Function-altering SNPs in MC3R have been found to be associated with greater adiposity in both children and adults.
Jain, Arad, Patel, Tushar P, Altman, Elizabeth K, Tugarinov, Nicol, Levi, Noah J, Elizondo, Diana M, Arner, Brooke E, Roberson, Robin B, Caron, Alexandre, Elmquist, Joel K, Yanovski, Jack A   +10 more
openaire   +1 more source

Pharmacological Evaluation of Melanocortin 2 Receptor Accessory Protein 2 on Axolotl Neural Melanocortin Signaling

Frontiers in Endocrinology, 2022
The Melanocortin-3 receptor (MC3R) and Melanocortin-4 receptor (MC4R), two members of the key hypothalamic neuropeptide signaling, function as complex mediators to control the central appetitive and energy homeostasis.
Xiaozhu Wang, Song Xue, Xiaowei Lei, Wenqi Song, Lei Li, Xuan Li, Yanbin Fu, Cong Zhang, Hailin Zhang, Hailin Zhang, Yao Luo, Meng Wang, Gufa Lin, Gufa Lin, Chao Zhang, Jing Guo   +15 more
doaj   +1 more source

Alk-Fam150b (augmentor α) expression in the paraventricular nucleus of the mouse hypothalamus at molecular resolution, and its sensitivity to acute stress. [PDF]

J Neuroendocrinol
In this study, Laurent Gueissaz and his colleagues use cell‐resolved molecular profiling and in situ hybridization to characterize cellular underpinnings of augmentor α‐ALK signaling in the paraventricular nucleus of the mouse hypothalamus. They also show that acute stress affects the transcription of augmentor α but not ALK, which can have functional ...
Gueissaz L, Sideromenos S, Tretiakov EO, Schnell R, Harkany T.   +4 more
europepmc   +2 more sources

Paraventricular ThalamicMC3RCircuits Link Energy Homeostasis with Anxiety-Related Behavior

The Journal of Neuroscience, 2023
The hypothalamic melanocortin system is critically involved in sensing stored energy and communicating this information throughout the brain, including to brain regions controlling motivation and emotion. This system consists of first-order agouti-related peptide (AgRP) and pro-opiomelanocortin (POMC) neurons located in the hypothalamic arcuate nucleus
Dajin, Cho, Kyle, O'Berry, Ingrid Camila, Possa-Paranhos, Jared, Butts, Naraen, Palanikumar, Patrick, Sweeney   +5 more
openaire   +2 more sources

Pharmacological modulation of the cAMP signaling of two isoforms of melanocortin-3 receptor by melanocortin receptor accessory proteins in the tetrapod Xenopus laevis

Endocrine Connections, 2021
As a member of the seven-transmembrane rhodopsin-like G protein-coupled receptor superfamily, the melanocortin-3 receptor (MC3R) is vital for the regulation of energy homeostasis and rhythms synchronizing in mammals, and its pharm acological effect could
Ying Xu, Lei Li, Jihong Zheng, Meng Wang, Bopei Jiang, Yue Zhai, Liumei Lu, Cong Zhang, Zhe Kuang, Xiaomei Yang, Li-Na Jin, Gufa Lin, Chao Zhang   +12 more
doaj   +1 more source

Regulation of Melanocortin-3 and -4 Receptors by Isoforms of Melanocortin-2 Receptor Accessory Protein 1 and 2

Biomolecules, 2022
The neural melanocortin receptors (MCRs), melanocortin-3 and -4 receptors (MC3R and MC4R), play essential non-redundant roles in the regulation of energy homeostasis. Interaction of neural MCRs and melanocortin-2 receptor accessory proteins (MRAPs, MRAP1
Ren-Lei Ji, Ya-Xiong Tao
doaj   +1 more source

Identification of novel GPCR partners of the central melanocortin signaling

Molecular Metabolism, 2021
Objective: Homo- or heterodimerization of G protein–coupled receptors (GPCRs) generally alters the normal functioning of these receptors and mediates their responses to a variety of physiological stimuli in vivo.
Yunpeng Li, Xiaozhu Wang, Liumei Lu, Meng Wang, Yue Zhai, Xiaolu Tai, Diliqingna Dilimulati, Xiaowei Lei, Jing Xu, Cong Zhang, Yanbin Fu, Shen Qu, Qingfeng Li, Chao Zhang   +13 more
doaj   +1 more source

Hypothalamic ventricular ependymal thyroid hormone deiodinases are an important element of circannual timing in the siberian hamster (Phodopus sungorus) [PDF]

, 2013
Exposure to short days (SD) induces profound changes in the physiology and behaviour of Siberian hamsters, including gonadal regression and up to 30% loss in body weight.
Barrett, Perry, Bolborea, Matei, Ebling, Francis J. P., Herwig, Annika, Mercer, Julian G., Morgan, Peter J., Vries, Emmely M. de, Wilson, Dana   +7 more
core   +7 more sources

Modulation of Canine Melanocortin-3 and -4 Receptors by Melanocortin-2 Receptor Accessory Protein 1 and 2

Biomolecules, 2022
The neural melanocortin receptors (MCRs), melanocortin-3 and -4 receptors (MC3R and MC4R), have crucial roles in regulating energy homeostasis. The melanocortin-2 receptor accessory proteins (MRAPs, MRAP1 and MRAP2) have been shown to regulate neural ...
Ren-Lei Ji, Shan-Shan Jiang, Ya-Xiong Tao   +2 more
doaj   +1 more source