Results 11 to 20 of about 4,530 (193)

Specific Functions of Melanocortin 3 Receptor (MC3R)

JCRPE, 2023
Melanocortin 3 receptor (MC3R) is a G-protein coupled receptor which has been defined mostly as a regulator of the appetite/hunger balance mechanisms to date.
Tulin Yanik, Seyda Tugce Durhan
doaj   +3 more sources

Medial hypothalamic MC3R signalling regulates energy rheostasis in adult mice [PDF]

Journal of Physiology
AbstractAlthough mammals resist both acute weight loss and weight gain, the neural circuitry mediating bi‐directional defense against weight change is incompletely understood. Global constitutive deletion of the melanocortin‐3‐receptor (MC3R) impairs the behavioural response to both anorexic and orexigenic stimuli, with MC3R knockout mice demonstrating
Dajin Cho, Patrick Sweeney
exaly   +4 more sources

Hepatic MC3R is a regulator of lipid droplet autophagy and liver steatosis [PDF]

Autophagy
Intrahepatic triglyceride breakdown and recycling occur through lipolysis and lipid droplet (LD) macroautophagy/autophagy to regulate systemic fat partitioning. We recently demonstrated that MC3R is important for hepatic autophagy and peripheral metabolism, beyond its established functions in the CNS, where it affects energy homeostasis, feeding ...
Tushar P Patel, Jack A Yanovski
exaly   +4 more sources

The melanocortin receptor genes are linked to and associated with the risk of polycystic ovary syndrome in Italian families [PDF]

Journal of Ovarian Research
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder occurring in women of reproductive age. The disease is caused by a complex interplay of genetic and environmental factors including genes encoding components of the hypothalamic ...
Rongling Wu, Claudia Gragnoli
doaj   +2 more sources

Study on Association of Single Nucleotide Polymorphism of MC3R and MC4R Genes with Carcass and Meat Quality Traits in Chicken

Journal of Poultry Science, 2009
Body composition, fat deposition and meat quality are important traits in chickens. Melanocortin receptor (MCR) plays an important role in central melanocortin system (CMS) and muscle cells.
Yan Wang, Yi Su, Xiaosong Jiang, Yiping Liu, Xiaocheng Li, Zengrong Zhang, Huarui Du, Qing Zhu   +7 more
exaly   +3 more sources

Exploring Autosomal Dominant Non-Syndromic Monogenic Obesity: From Genes to Therapy [PDF]

Current Issues in Molecular Biology
Genetic factors are key determinants in the pathophysiology of obesity, regulating energy homeostasis. Monogenic non-syndromic obesity accounts for 2–3% of obesity in both children and adults and is most often attributable to mutations in genes encoding ...
Giovanni Luppino, Mara Giordano, Francesca Franchina, Roberto Coco, Eleonora Inì, Carla Fazio, Debora Porri, Cecilia Lugarà, Domenico Corica, Tommaso Aversa, Malgorzata Wasniewska   +10 more
doaj   +2 more sources

Evaluation of the MC3R gene pertaining to body weight and height regulation and puberty development [PDF]

Scientific Reports, 2023
Recent studies reported an impact of the melanocortin 3 receptor (MC3R) on the regulation of body weight, linear growth and puberty timing. Previously, allele p.44Ile of a frequent non-synonymous variant (NSV) p.Val44Ile was reported to be associated ...
Yiran Zheng, Luisa Sophie Rajcsanyi, Triinu Peters, Astrid Dempfle, Stefan A. Wudy, Johannes Hebebrand, Anke Hinney   +6 more
doaj   +5 more sources

An exploratory microarray analysis of estrogen-mediated gene expression in central pathways that control energy balance in female rats (Rattus norvegicus) [PDF]

BMC Research Notes
Objective Obesity and associated conditions are concerning, especially during menopause. Estrogens influence energy balance in key brain regions including the arcuate nucleus (ARC), paraventricular nucleus (PVN), and the nucleus of the solitary tract ...
Henry Lang, Kaitlin Burch, Dusti Sloan
doaj   +2 more sources

Melanocortin 3 Receptors Do Not Specifically Localize to Primary Cilia in Cultured Human and Rodent Neurons. [PDF]

Cell Biochem Funct
ABSTRACT The melanocortin‐3 receptor (MC3R) and the melanocortin‐4 receptor (MC4R), both expressed in hypothalamic nuclei, are key downstream effectors of leptin signaling and play important roles in energy homeostasis. While pathogenic variants in the MC4R gene represent the most common cause of monogenic obesity, the clinical significance of MC3R ...
Vos N, Moro A, Hul WV, Kleinendorst L, Florijn RJ, la Fleur SE, Verhage M, van Haelst MM, Toonen RF.   +8 more
europepmc   +2 more sources

Topmouth culter melanocortin-3 receptor: regulation by two isoforms of melanocortin-2 receptor accessory protein 2

Endocrine Connections, 2021
Melanocortin-3 receptor (MC3R) is a regulator of energy homeostasis, and interaction of MC3R and melanocortin-2 receptor accessory protein 2 (MRAP2) plays a critical role in MC3R signaling of mammals.
Ren-Lei Ji, Lu Huang, Yin Wang, Ting Liu, Si-Yu Fan, Min Tao, Ya-Xiong Tao   +6 more
doaj   +1 more source