Results 41 to 50 of about 4,530 (193)

Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3 [PDF]

, 2016
This project was supported by Queen Mary Innovation Ltd Proof of Concept Fund (2012/13) and The William Harvey Research ...
Cook, JM, Forfar, RAE, Jerman, JC, Montero-Melendez, T, Perretti, M, Taylor, DL   +5 more
core   +1 more source

A Novel Melanocortin 3 Receptor Gene (MC3R) Mutation Associated with Severe Obesity [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2002
The melanocortin 3 receptor (MC3R) plays a critical role in weight regulation as demonstrated in mouse models. We describe a novel mutation Ile183Asn (T548A) found in heterozygosity in a 13-year-old obese girl and her father.The MC3R gene was sequenced in 41 unrelated obese children, and 121 DNA samples from non-obese individuals were analysed for this
Lee, Y.-S., Poh, L.K.-S., Loke, K.-Y.
openaire   +3 more sources

Generation of an MC3R knock-out pig by CRSPR/Cas9 combined with somatic cell nuclear transfer (SCNT) technology

Lipids in Health and Disease, 2019
Background Melanocortin 3 receptor (MC3R), a rhodopsin-like G protein-coupled receptor, is an important regulator of metabolism. Although MC3R knock-out (KO) mice and rats were generated in earlier studies, the function of MC3R remains elusive. Since pig
Yajun Yin, Haiyang Hao, Xingbin Xu, Liangcai Shen, Wenjing Wu, Jin Zhang, Qiuyan Li   +6 more
doaj   +1 more source

Role of the Melanocortin System in the Central Regulation of Cardiovascular Functions

Frontiers in Physiology, 2021
Increasing evidence indicates that the melanocortin system is not only a central player in energy homeostasis, food intake and glucose level regulation, but also in the modulation of cardiovascular functions, such as blood pressure and heart rate.
Francesca Copperi, Jung Dae Kim, Sabrina Diano, Sabrina Diano, Sabrina Diano   +4 more
doaj   +1 more source

An improved synthesis of Compound 11, a unique bicyclic melanocortin-3 antagonist. [PDF]

Pept Sci (Hoboken)
ABSTRACT The melanocortin‐3 receptor (MC3R) is a G‐protein coupled receptor that regulates appetite and is a potential therapeutic target for anorexia and weight loss treatments. The report of a highly selective synthetic antagonist of MC3R, Cpd11, represents a major advance toward therapeutic targeting of MC3R.
Joy ST, Dahir NS, Cone RD, Mapp AK.
europepmc   +2 more sources

Genetics of Common Obesity in Children and Adolescents. [PDF]

Ann N Y Acad Sci
Abstract Childhood obesity is a multifactorial public health problem worldwide. Genetic variation influences the predisposition to develop obesity at early stages of life. Childhood obesity may be classified as syndromic, monogenic, or polygenic depending on the genetic component.
León-Reyes G, Alavez FJL, Tejero ME.
europepmc   +2 more sources

The Melanocortin-4 Receptor Integrates Circadian Light Cues and Metabolism [PDF]

, 2015
The melanocortin system directs diverse physiological functions from coat color to body weight homoeostasis. A commonality among melanocortin-mediated processes is that many animals modulate similar processes on a circannual basis in response to longer ...
Arble, Deanna M., Herman, James P., Holland, Jenna, Morano, Rachel, Ottaway, Nickki, Perez-Tilve, Diego, Pressler, Joshua W., Sandoval, Darleen A., Seeley, Randy J., Sorrell, Joyce, Woods, Stephen C.   +10 more
core   +2 more sources

Melanocortin receptor accessory proteins in adrenal disease and obesity. [PDF]

, 2015
Melanocortin receptor accessory proteins (MRAPs) are regulators of the melanocortin receptor family. MRAP is an essential accessory factor for the functional expression of the MC2R/ACTH receptor.
Adrian J. Clark, Agulleiro, Asai, Balthasar, Beaumont, Beaumont, Begriche, Begriche, Berglund, Bouw, Breit, Catania, Chai, Chambers, Chan, Chen, Chen, Chida, Chung, Clark, Clark, Cone, Cooray, David S. Jackson, Dores, Elias, Farooqi, Gardiner, Getting, Gorrigan, Griffon, He, Hinkle, Hofland, Hu, Hughes, Huszar, Kay, Kay, Kiefer, Kim, Lee, Leoni, Li F. Chan, Lim, Liu, Loos, Lu, MacNeil, Mencarelli, Metherell, Mo, Moller, Montero-Melendez, Nijenhuis, Noon, O'Shaughnessy, Ollmann, Panaro, Park, Pritchard, Rodrigues, Roy, Roy, Rumie, Sebag, Sebag, Sebag, Sebag, Shutter, Shwetha Ramachandrappa, Smith, Sohn, Star, Sutton, Sutton, Sutton, Swope, Tontonoz, Vage, Vaisse, van der Kraan, van der Ploeg, Vinson, Webb, Xu, Yang, Yeo, Zhong   +88 more
core   +2 more sources

Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors

Cell Discovery, 2023
Members of the melanocortin receptor (MCR) family that recognize different melanocortin peptides mediate a broad spectrum of cellular processes including energy homeostasis, inflammation and skin pigmentation through five MCR subtypes (MC1R–MC5R).
Wenbo Feng, Qingtong Zhou, Xianyue Chen, Antao Dai, Xiaoqing Cai, Xiao Liu, Fenghui Zhao, Yan Chen, Chenyu Ye, Yingna Xu, Zhaotong Cong, Hao Li, Shi Lin, Dehua Yang, Ming-Wei Wang   +14 more
doaj   +1 more source

Evidence That Agouti-Related Peptide May Directly Regulate Kisspeptin Neurons in Male Sheep

Metabolites, 2021
Agouti-related peptide (AgRP) neurons, which relay information from peripheral metabolic signals, may constitute a key central regulator of reproduction.
Christina M. Merkley, Sydney L. Shuping, Jeffrey R. Sommer, Casey C Nestor   +3 more
doaj   +1 more source