Results 41 to 50 of about 76,131 (358)
Differential Signaling Profiles of MC4R Mutations with Three Different Ligands [PDF]
, 2020 The melanocortin 4 receptor (MC4R) is a key player in hypothalamic weight regulation and energy expenditure as part of the leptin-melanocortin pathway. Mutations in this G protein coupled receptor (GPCR) are the most common cause for monogenetic obesity,
Annibale, Paolo +8 more
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Frontiers in Genetics, 2022 Egg production rate in chicken is related to the continuity of follicle development. In this study, we found that the numbers of white prehierarchical, dominant, and yellow preovulatory follicles in the high-yielding layer breed, White Leghorn (WL), were
Yurong Tai +8 more
doaj +1 more source
Plasticity of differentiated cells in wound repair and tumorigenesis, Part II: Skin and intestine [PDF]
, 2018 Recent studies have identified and begun to characterize the roles of regenerative cellular plasticity in many organs. In Part I of our two-part Review, we discussed how cells reprogram following injury to the stomach and pancreas.
Burclaff, Joseph, Mills, Jason C
core +2 more sources
Journal of Dr. NTR University of Health Sciences, 2017 Oral melanotic nevi can be characterized as developmental malformations or melanocytic tumors. Nevi are benign in nature originating from proliferating malfunctioning melanoblasts of the neural crest cells either in the epithelium or in connective tissue.
Rithika Bashamalla +3 more
doaj +1 more source
Melanocytic Nevus of the Colon [PDF]
Case Reports in Gastroenterology, 2019 Here, we report a very rare case of melanocytic nevus of the colon. A 54-year-old woman with an unremarkable medical history visited our hospital for screening colonoscopy. Colonoscopy revealed a pigmented flat lesion in the ascending colon. Histological evaluation of a biopsy specimen revealed proliferation of pigmented cells in the lamina muscularis ...
Tamotsu Sugai +5 more
openaire +3 more sources
Mohs micrographic surgery for melanoma: A convincing treatment modality
Indian Journal of Dermatology, 2022 Mohs micrographic surgery (MMS) is the gold standard for treating keratinocyte carcinomas in specific locations or due to other tumor-specific factors, given its comprehensive margin assessment, tissue sparing, and high cure rate.
Stephanie Clements, Amor Khachemoune
doaj +1 more source
Modulation of social behavior by the agouti pigmentation gene [PDF]
, 2014 Agouti is a secreted neuropeptide that acts as an endogenous antagonist of melanocortin receptors. Mice and rats lacking agouti (called non-agouti) have dark fur due to a disinhibition of melanocortin signaling and pigment deposition in the hair follicle.
Carola V +5 more
core +1 more source
Frontiers in Oncology, 2021 Pituitary adenylate cyclase activating polypeptide (PACAP) is an endogenous neuropeptide which is distributed throughout the body. PACAP influences development of various tissues and exerts protective function during cellular stress and in some tumour ...
Tibor Hajdú +14 more
doaj +1 more source
p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis. [PDF]
, 2013 The role of apoptosis in melanoma pathogenesis and chemoresistance is poorly characterized. Mutations in TP53 occur infrequently, yet the TP53 apoptotic pathway is often abrogated.
Akslen +143 more
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Frontiers in Pigment Cell and Melanoma Research
, 2018 We identify emerging frontiers in clinical and basic research of melanocyte biology and its associated biomedical disciplines. We describe challenges and opportunities in clinical and basic research of normal and diseased melanocytes that impact current ...
Birlea, Stanca +26 more
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