Results 101 to 110 of about 85,786 (342)

SOX10, MITF, and microRNAs: Decoding their interplay in regulating melanoma plasticity

International Journal of Cancer, EarlyView.
Abstract Recent studies show that the dysregulation of the transcription factor SOX10 is essential for the development and progression of melanoma. MicroRNAs (miRNAs) can regulate the expression of transcription factors at the post‐transcriptional level. The interactions between SOX10 and its targeting miRNAs form network motifs such as feedforward and
Xin Lai, Chunyan Luan, Zhesi Zhang, Anja Wessely, Markus V. Heppt, Carola Berking, Julio Vera   +6 more
wiley   +1 more source

A modelling approach towards Epidermal homoeostasis control

, 2007
In order to grasp the features arising from cellular discreteness and individuality, in large parts of cell tissue modelling agent-based models are favoured.
Barthel, Bashir, Bauer, Benoit, Bettelheim, Brilliantov, Byrne, Carvalho, Chenevert, Chu, Cickovski, Dallon, Dormann, Drasdo, Drasdo, Edelsbrunner, Ferreira, Fletcher, Freyer, Freyer, Galle, Galle, Gardner, Gatenby, Gernot Schaller, Gershenfeld, Graner, Hertz, Hoath, Johnson, Johnson, Joos, Kasting, Kreft, Kreft, Kreft, Landau, Livingston, Louzoun, Mahaffy, Maniotis, Meineke, Meyer-Hermann, Michael Meyer-Hermann, Montagna, Moy, Newman, Norlen, Picioreanu, Potten, Press, Savill, Schaller, Schaller, Schaller, Schwindt, Smolle, Tang, Tuchin, Turner, Verdier, von Neumann, Wehrle, Weliky, Weliky   +64 more
core   +1 more source

Generation and functional analysis of melanoma antigen‐specific CD8+ T cells derived from S/MAR vector‐transfected human induced pluripotent stem cells

International Journal of Cancer, EarlyView.
What's New? Adoptive cell therapy (ACT) with tumor antigen‐specific CD8+ T cells has shown success in clinical trials treating patients with advanced or metastatic melanoma. Here, the authors established protocols for generating CD8+ T cells from human induced pluripotent stem cells (hiPSCs) expressing a melanoma‐specific T cell receptor (TCR) or ...
Juliane Poelchen, Sandra Pardo, Daniel Novak, Qian Sun, Tamara Steinfass, Marlene Vierthaler, Özge Cicek Sener, Karol Granados Blanco, Yiman Wang, Jan Peter Nicolay, Pierre Guermonprez, Richard Harbottle, Viktor Umansky, Jochen Utikal   +13 more
wiley   +1 more source

Twenty‐year survival outcomes after multipeptide vaccination for resected high‐risk melanoma: A post‐hoc analysis of a randomized clinical trial

International Journal of Cancer, EarlyView.
What's New? While melanoma vaccines have shown therapeutic promise, predicting their clinical benefits is challenged by factors such as delayed response to immunotherapy and scarcity of biomarkers. Here, the authors examined the long‐term efficacy of vaccination with either 4 or 12 class I MHC‐restricted peptides in high‐risk melanoma.
Emily K. Ninmer, Hong Zhu, Kimberly A. Chianese‐Bullock, Craig L. Slingluff Jr.   +3 more
wiley   +1 more source

Shedding light on melanins within in situ human eye melanocytes using 2-photon microscopy profiling techniques. [PDF]

, 2019
Choroidal melanocytes (HCMs) are melanin-producing cells in the vascular uvea of the human eye (iris, ciliary body and choroid). These cranial neural crest-derived cells migrate to populate a mesodermal microenvironment, and display cellular functions ...
Cherepanoff, Svetlana, Conway, Robert Max, Gratton, Enrico, Macmillan, Alexander, Madigan, Michele C, Sitiwin, Ephrem, Whan, Renee   +6 more
core  

Wnt Signaling in Neural Crest Ontogenesis and Oncogenesis. [PDF]

, 2019
Neural crest (NC) cells are a temporary population of multipotent stem cells that generate a diverse array of cell types, including craniofacial bone and cartilage, smooth muscle cells, melanocytes, and peripheral neurons and glia during embryonic ...
Hao, Hongyan, Ji, Yu, McMahon, Moira, Reynolds, Kurt, Zhou, Chengji J   +4 more
core   +2 more sources

Optimized reconstruction of the absorption spectra of kidney tissues from the spectra of tissue components using the least squares method

Journal of Biophotonics, EarlyView.
The absorption coefficient spectra of healthy and cancerous kidney tissues were reconstructed from the absorption spectra of tissue components using constant weights. Both reconstructions allowed to calculate the concentrations of the tissue components and a comparison between the healthy and chromophobe renal cell carcinoma kidney showed an increase ...
Maria R. Pinheiro, Luís E. Fernandes, Isa C. Carneiro, Sónia D. Carvalho, Rui M. Henrique, Valery V. Tuchin, Hélder P. Oliveira, Luís M. Oliveira   +7 more
wiley   +1 more source

Studies on pituitary polypeptide hormones. 1. The structure of β-melanocyte-stimulating hormone from pig pituitary glands [PDF]

, 1959
J. Ieuan Harris, P. Roos
openalex   +1 more source

Early- and late-migrating cranial neural crest cell populations have equivalent developmental potential in vivo [PDF]

, 1997
We present the first in vivo study of the long-term fate and potential of early-migrating and late-migrating mesencephalic neural crest cell populations, by performing isochronic and heterochronic quail-to-chick grafts.
Baker, Clare V. H., Bronner-Fraser, Marianne, Le Douarin, Nicole M., Teillet, Marie-Aimée   +3 more
core  

Melasma: A clinicopathological study of 43 cases

Indian Journal of Pathology and Microbiology, 2009
Melasma is a symmetrical hypermelanosis of the exposed skin characterized by brown macules on the sun-exposed areas of the skin. The present study was carried out on 43 patients to analyze the correlation between histopathological features with clinical ...
Sarvjot Vermani, Sharma Shruti, Mishra Sharmila, Singh Avninder   +3 more
doaj