Results 101 to 110 of about 116,555 (410)
Genetically engineered minipigs model the major clinical features of human neurofibromatosis type 1. [PDF]
, 2018 Neurofibromatosis Type 1 (NF1) is a genetic disease caused by mutations in Neurofibromin 1 (NF1). NF1 patients present with a variety of clinical manifestations and are predisposed to cancer development.
Carlson, Daniel F +21 more
core +2 more sources
Interferon-γ Induces Senescence in Normal Human Melanocytes
PLoS ONE, 2014 Background Interferon-γ (IFN-γ) plays an important role in the proceedings of vitiligo through recruiting lymphocytes to the lesional skin. However, the potential effects of IFN-γ on skin melanocytes and the subsequent contribution to the vitiligo ...
Suiquan Wang +7 more
semanticscholar +1 more source
Assessment of melanogenesis in a pigmented human tissue-cultured skin equivalent
Indian Journal of Dermatology, 2019 Background: Organotypic tissue-cultured skin equivalents are used for a broad range of applications either as possible substitute for animal tests or for transplantation in patient-centered care.
Nadja Nicole Zoller +8 more
doaj +1 more source
From Tank to Treatment: Modeling Melanoma in Zebrafish
Cells, 2020 Melanoma is the deadliest form of skin cancer and one of few cancers with a growing incidence. A thorough understanding of its pathogenesis is fundamental to developing new strategies to combat mortality and morbidity.
William Tyler Frantz, Craig J Ceol
doaj +1 more source
Data-Driven Deep Supervision for Skin Lesion Classification [PDF]
arXiv, 2022 Automatic classification of pigmented, non-pigmented, and depigmented non-melanocytic skin lesions have garnered lots of attention in recent years. However, imaging variations in skin texture, lesion shape, depigmentation contrast, lighting condition, etc. hinder robust feature extraction, affecting classification accuracy.
arxiv
Melanocytes in the Skin – Comparative Whole Transcriptome Analysis of Main Skin Cell Types
PLoS ONE, 2014 Melanocytes possess several functions besides a role in pigment synthesis, but detailed characteristics of the cells are still unclear. We used whole transcriptome sequencing (RNA-Seq) to assess differential gene expression of cultivated normal human ...
P. Reemann +8 more
semanticscholar +1 more source
Vitiligo and the melanocyte reservoir
Indian Journal of Dermatology, 2009 Repigmentation of vitiligo depends on available melanocytes from three possible sources: from the hair follicle unit which is the main provider of pigment cells, from the border of vitiligo lesions, and from unaffected melanocytes within depigmented areas; pigment cells at these locations originate a perifollicular, border spreading and a diffuse ...
openaire +4 more sources
Kit and Melanocyte Migration [PDF]
Journal of Investigative Dermatology, 2006 As described in this issue, Alexeev and Yoon introduced a Kit-activating mutation into melanocytes. Although mitogenic in mast cells, this mutation was motogenic in melanocytes. Further, melanocytes had a reduced proliferative rate and were less differentiated.
openaire +3 more sources
Detection of circulating tumor cells is achieved by flow cytometry in melanoma patients
Cytometry Part B: Clinical Cytometry, EarlyView.Abstract Melanoma is an aggressive skin tumor whose incidence is rising sharply, and for which the determination of new prognostic factors is a major challenge. In oncology, circulating tumor cells (CTCs) are at the heart of much research, as they represent a source of tumor material obtained non‐invasively by liquid biopsy.
Ludivine Fourdrain +7 more
wiley +1 more source
Extended Feature Space-Based Automatic Melanoma Detection System [PDF]
arXiv, 2022 Melanoma is the deadliest form of skin cancer. Uncontrollable growth of melanocytes leads to melanoma. Melanoma has been growing wildly in the last few decades. In recent years, the detection of melanoma using image processing techniques has become a dominant research field.
arxiv