Results 131 to 140 of about 116,555 (410)

Mitotic stress is an integral part of the oncogene-induced senescence program that promotes multinucleation and cell cycle arrest [PDF]

, 2015
Oncogene-induced senescence (OIS) is a tumor suppression mechanism that blocks cell proliferation in response to oncogenic signaling. OIS is frequently accompanied by multinucleation; however, the origin of this is unknown.
Adams, Peter D., Athineos, Dimitris, Berger, Shelley L., Blyth, Karen, Brock, Claire, Clark, William, Cole, John J., Dikovskaya, Dina, Hewitt, Rachael N., Karim, Saadia A., Leach, Joshua D. G., Marchesi, Francesco, Mason, Susan M., McGarry, Lynn, Morton, Jennifer P., Nixon, Colin, Sammons, Morgan A., Tait, Stephen W., van Tuyn, John, Wu, Hong, Zhu, Jiajun   +20 more
core   +2 more sources

Recent Advancements in the Characterization of D‐Amino Acid and Isoaspartate Post‐Translational Modifications

Mass Spectrometry Reviews, EarlyView.
ABSTRACT One of the great triumphs of mass spectrometry‐based peptide and protein characterization is the characterization of their modifications as most modifications have a characteristic mass shift. What happens when the modification does not change the mass of the peptide?
Samuel Okyem, Jonathan V. Sweedler
wiley   +1 more source

Molecular Pathways Regulating Circadian Rhythm and Associated Diseases

Frontiers in Bioscience-Landmark
Circadian rhythms, the natural cycles of physical, mental, and behavioral changes that follow a roughly 24-hour cycle, are known to have a profound effect on the human body.
Min Ding, Hang Zhou, Yu-Mei Li, Yun-Wen Zheng   +3 more
doaj   +1 more source

Distribution of melanocytes in the skin of psoriasis patients

Vestnik Dermatologii i Venerologii, 2019
Psoriasis is a chronic immune-mediated inflammatory disease with predominant damage to the skin and joints. Despite fundamental studies of its pathogenesis, the cause of the development of the T-cell response has not been determined. More recently, a new
A. S. Zhukov, V. R. Khairutdinov, I. E. Belousova, A. V. Samtsov   +3 more
doaj   +1 more source

Melanoma Diagnosis with Spatio-Temporal Feature Learning on Sequential Dermoscopic Images [PDF]

arXiv, 2020
Existing studies for automated melanoma diagnosis are based on single-time point images of lesions. However, melanocytic lesions de facto are progressively evolving and, moreover, benign lesions can progress into malignant melanoma. Ignoring cross-time morphological changes of lesions thus may lead to misdiagnosis in borderline cases. Based on the fact
arxiv  

Primary melanoma of the CNS in children is driven by congenital expression of oncogenic NRAS in melanocytes.

Cancer Discovery, 2013
UNLABELLED NRAS mutations are common in human melanoma. To produce a mouse model of NRAS-driven melanoma, we expressed oncogenic NRAS (NRAS(G12D)) in mouse melanocytes.
M. Pedersen, H. Küsters-Vandevelde, A. Virós, P. Groenen, B. Sanchez-Laorden, Jacobus H Gilhuis, I. A. van Engen-van Grunsven, W. Renier, J. Schieving, I. Niculescu-Duvaz, C. Springer, B. Küsters, P. Wesseling, W. Blokx, R. Marais   +14 more
semanticscholar   +1 more source

Whole‐genome CRISPR‐Cas9 knockout screens identify SHOC2 as a genetic dependency in NRAS‐mutant melanoma

Cancer Communications, EarlyView.
Andrea Y. Gu, Tet Woo Lee, Aziza Khan, Xuenan Zhang, Francis W. Hunter, Dean C. Singleton, Stephen M. F. Jamieson   +6 more
wiley   +1 more source

Clinicopathologic Features, Management, and Outcomes Of Pediatric CRTC1::TRIM11 and MED15::ATF1 Tumors With Spitzoid Morphology: A Case Series

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Limited information is available on the clinicopathologic features and management of pediatric CRTC1::TRIM11 (CTRTs) and MED15::ATF1‐rearranged tumors (MARTs). In this series of pediatric CTRTs (n = 5) and MARTs (n = 2), all tumors exhibited spitzoid morphology and expressed melanocytic markers.
Michael R. Sargen, Madeline H. Fitzhugh, Jennifer S. Ko, Allison G. Close, Sara C. Horton, Faizan Malik, Larissa V. Furtado, Armita Bahrami, Brittani K. N. Seynnaeve, Alberto S. Pappo, Vincent Liu, Kevin Cheung, Svetlana D. Pack, Liqiang Xi, Mark Raffeld, Ina Lee, Jeffrey Gagan, Kenneth Aldape, Frederic G. Barr, Stephen M. Hewitt, Christina K. Ferrone, Anna Hayden, Jessica N. Hatton, Alisa M. Goldstein, Ruth M. Pfeiffer, Brigitte Widemann, Mary Frances Wedekind Malone, Andrea M. Gross, Rosandra Kaplan, Marielle E. Yohe, Kristen G. Berrebi   +30 more
wiley   +1 more source

A Nude Mouse Model of Xenografted Hypertrophic Scar Cells to Test Therapeutics in the Skin

Frontiers in Bioscience-Landmark
Background: Existing animal models for testing therapeutics in the skin are limited. Mouse and rat models lack similarity to human skin in structure and wound healing mechanism. Pigs are regarded as the best model with regards to similarity to human skin;
Bonnie C. Carney, Cynthia M. Simbulan-Rosenthal, Dean S. Rosenthal, Jeffrey W. Shupp   +3 more
doaj   +1 more source

PEARL: Protein Eluting Alginate with Recombinant Lactobacilli

Small, EarlyView.
Probiotic lactobacilli meet engineered living materials: This study introduces PEARL (protein eluting alginate with recombinant lactobacilli), an innovative engineered living material combining Lactiplantibacillus plantarum and alginate beads for controlled protein release.
Varun Sai Tadimarri, Marc Blanch‐Asensio, Ketaki Deshpande, Jonas Baumann, Carole Baumann, Rolf Müller, Sara Trujillo, Shrikrishnan Sankaran   +7 more
wiley   +1 more source