Results 131 to 140 of about 85,786 (342)

Single-Cell Transcriptomes Reveal a Complex Cellular Landscape in the Middle Ear and Differential Capacities for Acute Response to Infection. [PDF]

, 2020
Single-cell transcriptomics was used to profile cells of the normal murine middle ear. Clustering analysis of 6770 transcriptomes identified 17 cell clusters corresponding to distinct cell types: five epithelial, three stromal, three lymphocyte, two ...
Draf, Clara, Fisch, Kathleen M, Kurabi, Arwa, Nasamran, Chanond A, Pak, Kwang, Ryan, Allen F, Webster, Nicholas   +6 more
core  

Use of Ultraviolet‐Induced Fluorescence Dermoscopy for the Diagnosis of Vitiligo‐Like Lesions in Patients Receiving Immune Checkpoint Inhibitors Therapy for Advanced Melanoma: Letter to the Editor

JEADV Clinical Practice, EarlyView.
Laura Rackauskaite, Diana C. O. Jimenez, Iris Zalaudek   +2 more
wiley   +1 more source

A call to integrate non‐visual functions of pigments and their interactions with visual functions to understand global change impacts on visual systems

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Animal coloration serves a variety of visually related functions in nature (e.g. mate choice, aposematism and camouflage) but the pigments in integumentary tissues such as skin, scales and feathers may also serve functions unrelated to the visual environment (e.g ...
Beth A. Reinke, Julian D. Avery, Jessica Hua   +2 more
wiley   +1 more source

Imatinib decreases germ cell survival and germline stem cell proliferation in rodent testis ex vivo and in vitro

Andrology, EarlyView.
Abstract Background Imatinib and dasatinib are tyrosine kinase inhibitors (TKIs) increasingly used to treat several diseases in both children and adults at fertile age. We have previously shown that imatinib has adverse effects on developing testis, and imatinib‐treated male patients have been reported to have reduced sperm counts.
Anna Eggert, Sini Laasanen, Mirja Nurmio, Aida Wahlgren, Kirsi Jahnukainen, Kim Eerola, Miisael Nieminen, Opeyemi Olotu, Noora Kotaja, Juho‐Antti Mäkelä, Jorma Toppari   +10 more
wiley   +1 more source

Molecular Pathways Regulating Circadian Rhythm and Associated Diseases

Frontiers in Bioscience-Landmark
Circadian rhythms, the natural cycles of physical, mental, and behavioral changes that follow a roughly 24-hour cycle, are known to have a profound effect on the human body.
Min Ding, Hang Zhou, Yu-Mei Li, Yun-Wen Zheng   +3 more
doaj   +1 more source

Prognosis and determinants of survival after orbital exenteration for conjunctival melanoma: Experiences from a Dutch Referral Centre

Acta Ophthalmologica, EarlyView.
Abstract Purpose To assess the prognosis and determinants of survival after orbital exenteration in patients with conjunctival melanoma (CoM). Methods In a retrospective study, 27 consecutive patients who underwent exenteration for CoM from 2001 to 2023 were included.
David Chetroiu, Niels J. Brouwer, Marina Marinkovic, Gregorius P. M. Luyten, Jaco C. Bleeker, Robert M. Verdijk, T. H. Khanh Vu, Stijn W. van der Meeren   +7 more
wiley   +1 more source

CTLA-4 A49G gene polymorphism is not associated with vitiligo in South Indian population

Indian Journal of Dermatology, 2010
Background: Vitiligo or leukoderma is a chronic skin condition that causes loss of pigment due to destruction of melanocytes, resulting in irregular pale patches of skin.
Deeba Farha, Syed Rabbani, Quareen Jariya, Waheed M, Jamil Kaiser, Rao Hanmanth   +5 more
doaj  

A Nude Mouse Model of Xenografted Hypertrophic Scar Cells to Test Therapeutics in the Skin

Frontiers in Bioscience-Landmark
Background: Existing animal models for testing therapeutics in the skin are limited. Mouse and rat models lack similarity to human skin in structure and wound healing mechanism. Pigs are regarded as the best model with regards to similarity to human skin;
Bonnie C. Carney, Cynthia M. Simbulan-Rosenthal, Dean S. Rosenthal, Jeffrey W. Shupp   +3 more
doaj   +1 more source

Prospects for non-immunological molecular therapeutics in melanoma [PDF]

, 2010
In 2006 there were 60,000 new cases of cutaneous melanoma in the European Union and 13,000 deaths (www.europeancancerleagues.org). Currently available systemic treatment options for metastatic melanoma, including both cytotoxic and immunologic therapies,
Crown, John, Eustace, Alexander J., Mahgoub, Thamir, O'Donovan, Norma, Tryfonopoulos, Dimitrios   +4 more
core  

Characterisation of localised pigment accumulation in brains of eastern grey kangaroos (Macropus giganteus) after clinical disease due to chronic Phalaris species toxicosis

Australian Veterinary Journal, EarlyView.
A progressive tremorgenic syndrome characterised by ataxia and head nodding is well documented in sheep and cattle affected by chronic Phalaris toxicosis (CPT), and is increasingly documented in the eastern grey kangaroo {(EGK), Macropus giganteus} in southeastern Australia.
C El‐Hage, T Chen, L Tatarczuch, J Hufschmid, LF Skerratt, P Whiteley, N Davis, R Ploeg   +7 more
wiley   +1 more source