Results 101 to 110 of about 458,085 (304)
Explainable Artificial Intelligence Architecture for Melanoma Diagnosis Using Indicator Localization and Self-Supervised Learning [PDF]
arXiv, 2023 Melanoma is a prevalent lethal type of cancer that is treatable if diagnosed at early stages of development. Skin lesions are a typical indicator for diagnosing melanoma but they often led to delayed diagnosis due to high similarities of cancerous and benign lesions at early stages of melanoma.
arxiv
New Insights into the Runt Domain of RUNX2 in Melanoma Cell Proliferation and Migration [PDF]
, 2018 The mortality rate for malignant melanoma (MM) is very high, since it is highly invasive and resistant to chemotherapeutic treatments. The modulation of some transcription factors affects cellular processes in MM.
Antoniazzi, Franco +19 more
core +2 more sources
Immunosurveillance and Melanoma
Journal of Investigative Dermatology, 1989 There is considerable indirect and some direct evidence that immune mechanisms can play an important role in controlling the growth of melanoma. In mice, melanoma can be prevented with vaccines. Consequently, even though naturally occurring immunosurveillance may not be sufficiently potent to prevent melanoma, it is possible that the prophylactic ...
openaire +3 more sources
Molecular Oncology, EarlyView.The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh +6 more
wiley +1 more source
Image Classification of Melanoma, Nevus and Seborrheic Keratosis by Deep Neural Network Ensemble [PDF]
arXiv, 2017 This short paper reports the method and the evaluation results of Casio and Shinshu University joint team for the ISBI Challenge 2017 - Skin Lesion Analysis Towards Melanoma Detection - Part 3: Lesion Classification hosted by ISIC. Our online validation score was 0.958 with melanoma classifier AUC 0.924 and seborrheic keratosis classifier AUC 0.993.
arxiv
Long non-coding RNAs in cutaneous melanoma : clinical perspectives [PDF]
, 2017 Metastatic melanoma of the skin has a high mortality despite the recent introduction of targeted therapy and immunotherapy. Long non-coding RNAs (lncRNAs) are defined as transcripts of more than 200 nucleotides in length that lack protein-coding ...
Brochez, Lieve +4 more
core +1 more source
Molecular Oncology, EarlyView.Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka +10 more
wiley +1 more source
Journal of Orthopaedic Surgery and Research, 2019 Background Osteosarcoma is the most common primary malignant bone tumor in adults and is usually located in the long bones. Standard treatment consists of perioperative chemotherapy and radical surgical resection.
Tomasz Goryń +5 more
doaj +1 more source
Germline variants in CDKN2A wild‐type melanoma prone families
Molecular Oncology, EarlyView.Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen +5 more
wiley +1 more source