Results 101 to 110 of about 869,771 (326)

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Real-World Efficacy and Safety of Anti-PD-1 Antibody Plus Apatinib and Temozolomide for Advanced Acral Melanoma

Cancer Management and Research
Jiaran Zhang,1,* Huichun Tian,1,* Lili Mao,1 Caili Li,1 Xiaoting Wei,1 Junjie Gu,1 Xuan Wang,1 Li Zhou,2 Bin Lian,1 Bixia Tang,1 Xieqiao Yan,2 Siming Li,2 Chuanliang Cui,1 Zhihong Chi,1 Xinan Sheng,2 Jun Guo,1 Lu Si1 1Department of ...
Zhang J, Tian H, Mao L, Li C, Wei X, Gu J, Wang X, Zhou L, Lian B, Tang B, Yan X, Li S, Cui C, Chi Z, Sheng X, Guo J, Si L   +16 more
doaj  

A single gene mutation predicts response to immune checkpoint blockade in ovarian clear cell carcinoma

Molecular Oncology, EarlyView.
Loss‐of‐function mutations in the scaffold subunit of protein phosphatase 2A (PP2A), PPP2R1A, sensitize ovarian clear cell carcinoma to immune checkpoint blockade (ICB) by enhancing the interferon gamma response and promoting antitumor immune cell infiltration.
Matheus Henrique Dias, René Bernards
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

In Vivo Noninvasive Imaging of Healthy Lower Lip Mucosa: A Correlation Study between High-Definition Optical Coherence Tomography, Reflectance Confocal Microscopy, and Histology

Dermatology Research and Practice, 2013
In recent years, technology has allowed the development of new diagnostic techniques which allow real-time, in vivo, noninvasive evaluation of morphological changes in tissue.
Alejandra García-Hernández, Rodrigo Roldán-Marín, Pablo Iglesias-Garcia, Josep Malvehy   +3 more
doaj   +1 more source

LNK suppresses interferon signaling in melanoma. [PDF]

, 2019
LNK (SH2B3) is a key negative regulator of JAK-STAT signaling which has been extensively studied in malignant hematopoietic diseases. We found that LNK is significantly elevated in cutaneous melanoma; this elevation is correlated with hyperactive ...
Ding, Ling-Wen, Doan, Ngan, Edwards, Jarem J, Fernández, Lucia Torres, Koeffler, H Phillip, Lin, De-Chen, Loh, Xin-Yi, Mullins, David W, Pein, Maren, Ran, Xue-Bin, Said, Jonathan W, Scolyer, Richard A, Sun, Qiao-Yang, Thompson, John F, Venkatachalam, Nachiyappan, Wilmott, James S, Xiao, Jin-Fen, Xu, Liang, Yang, Henry, Zhou, Si-Qin   +19 more
core  

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Multidisciplinary Management of Palpebral Melanoma

Plastic and Reconstructive Surgery, Global Open
Summary:. Ocular melanoma encompasses the uveal tract, conjunctiva, eyelid, and orbit. Palpebral localization is extremely infrequent, constituting less than 1% of skin melanomas, the main treatment of which is surgical.
Marcelo Chávez Díaz, MD, Otto Ziegler Rodríguez, MD, FACS, Gonzalo Ziegler Rodríguez, MD, Jaime Montes Gil, MD, Gabriel De la Cruz Ku, MD, Carla Carina Cedrón Lenci, MD, Otto Ziegler-Gutierrez, MD   +6 more
doaj   +1 more source

A Novel Method to Generate and Expand Clinical-Grade, Genetically Modified, Tumor-Infiltrating Lymphocytes

Frontiers in Immunology, 2017
Following the clinical success achieved with the first generation of adoptive cell therapy (ACT) utilizing in vitro expanded tumor-infiltrating lymphocytes (TILs), the second and third generations of TIL ACT are evolving toward the use of genetically ...
Marie-Andrée Forget, René J. Tavera, Cara Haymaker, Renjith Ramachandran, Shuti Malu, Minying Zhang, Seth Wardell, Orenthial J. Fulbright, Chistopher Leroy Toth, Audrey M. Gonzalez, Shawne T. Thorsen, Esteban Flores, Arely Wahl, Weiyi Peng, Rodabe N. Amaria, Patrick Hwu, Chantale Bernatchez   +16 more
doaj   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source