Results 21 to 30 of about 933,936 (328)

Histone deacetylase inhibitors induce invasion of human melanoma cells in vitro via differential regulation of N-cadherin expression and RhoA activity [PDF]

, 2016
Background: Histone deacetylase inhibitors (HDACi) exert multiple cytotoxic actions on cancer cells. Currently, different synthetic HDACi are in clinical use or clinical trials; nevertheless, since both pro-invasive and anti-invasive activities have been
Andrade, Ricardo, Arluzea, Jon, Aréchaga, Juan, De Wever, Olivier, Díaz-Núñez, María, Díez-Torre, Alejandro, Silió, Margarita   +6 more
core   +4 more sources

10 | Prognostic value of trans epidermal water loss in the treatment of actinic keratoses. A comparison amongst topical therapies for field cancerization

Dermatology Reports
Background: Actinic keratoses (AKs) are one of the most common premalignant skin conditions in the overall population. AKs are considered early precursors that may occasionally progress to squamous cell carcinoma.
Italian Melanoma Intergroup
doaj   +1 more source

Understanding signaling cascades in melanoma [PDF]

, 2008
Understanding regulatory pathways involved in melanoma development and progression has advanced significantly in recent years. It is now appreciated that melanoma is the result of complex changes in multiple signaling pathways that affect growth control,
Akslen L. A., Berger A. J., Berking C., Bhoumik A., Bhoumik A., Chen X., Claffey K. P., Collisson E. A., Coppock D. L., Dahia P. L. M., Dhawan P., Dorsky R. I., Ehebauer M., Eisenmann K. M., Genersch E., Goding C. R., Goodall J., Gorden A., Guldberg P., Gurzov E. N., Herbst R. A., Hingorani S. R., Hughes M. J., Huguier S., Iozzo R. V., Jonsson M., Jorgensen K., Karin M., Kennedy N. J., Kumar R., Lacal P. M., Li N., Maeno K., Meyskens F. L., Miller J. R., Miyazono K., Niu G., Okuyama R., Omholt K., Park B. K., Piek E., Qin J.-Z., Rangaswami H., Rimm D. L., Rofstad E. K., Satyamoorthy K., Soldatencov V. A., Stewart F. A., Tago K.-i., Thomson J. A., Tokita T., Tsai E. Y., Tsao H., van Elsas A., Wu M., Yang J., Yang J., Yang Y. M., Zhou X. P.   +58 more
core   +1 more source

16 | Sentinel lymph node biopsy in elderly patients with melanoma: prognostic value and impact on recurrence

Dermatology Reports
Background: The role of sentinel lymph node biopsy (SLNB) in elderly patients affected by cutaneous melanoma (CM) remains debated due to comorbidities, surgical risks and especially given the lower SLN positivity rates.
Italian Melanoma Intergroup
doaj   +1 more source

Demographic, Clinical, and Pathologic Features of Patients With Cutaneous Melanoma: Final Analysis of the Brazilian Melanoma Group Database

JCO Global Oncology, 2020
PURPOSE National epidemiologic data on melanoma are scarce in Brazil. The current work presents final demographic, clinical, and pathologic results from the Brazilian Melanoma Group database to detail how patients with melanoma present at diagnosis ...
Alberto Julius Alves Wainstein, João Pedreira Duprat Neto, Mauro Yoshiaki Enokihara, Eduard René Brechtbühl, Felice Riccardi, Gilles Landman, Andreia Cristina de Melo, Vinicius de Lima Vazquez, Rodrigo Ramella Munhoz, Ivan Dunshee De Abranches Oliveira Santos Filho, Eduardo Bertolli, Ana Paula Drummond-Lage, Bianca Costa Soares de Sá, Luciane Botelho, Jose Higino Steck, Francisco Aparecido Belfort, Marcus Maia, Renato Marchiori Bakos, Elimar Elias Gomes, Rafael Schmerling, Flavio Cavarsan   +20 more
doaj   +1 more source

Malignant melanoma of the urethra: a rare histologic subdivision of vulvar cancer with a poor prognosis [PDF]

, 2012
Malignant melanoma of the urethra is a rare tumour that is difficult to diagnose and treat, resulting in a poor prognosis. In this paper, we present the case of a 65-year-old woman who was referred to a gynaecologist because of a urethral mass that ...
Alkatout, Ibrahim, Altarac, Silvio, Cupic, Hrvoje, Fures, Rajko, Günther, Veronika, Hrgovic, Zlatko, Lez, Cvjetko, Mundhenke, Christoph, Persec, Zoran   +8 more
core   +2 more sources

Melanocortin 1 receptor targeted imaging of melanoma with gold nanocages and positron emission tomography [PDF]

, 2018
Purpose: Melanoma is a lethal skin cancer with unmet clinical needs for targeted imaging and therapy. Nanoscale materials conjugated with targeting components have shown great potential to improve tumor delivery efficiency while minimizing undesirable ...
Black, Kvar, Detering, Lisa, Liu, Yongjian, Luehmann, Hannah, Pang, Bo, Sultan, Deborah, Xia, Younan, Yang, Miaoxin, Zhao, Yongfeng   +8 more
core   +2 more sources

microRNA-33a-5p increases radiosensitivity by inhibiting glycolysis in melanoma. [PDF]

, 2017
Glycolysis was reported to have a positive correlation with radioresistance. Our previous study found that the miR-33a functioned as a tumor suppressor in malignant melanoma by targeting hypoxia-inducible factor1-alpha (HIF-1α), a gene known to promote ...
Cao, Ke, Chen, Jia, Chen, Xiang, Chen, Yao, Chen, Yong, Cheng, Yan, Li, Jingjing, Qian, Li, Tang, Jintian, Tang, Shijie, Wang, Aijun, Xiong, Wei, Zhou, Jianda   +12 more
core   +1 more source

m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade [PDF]

, 2019
Melanoma is one of the most deadly and therapy-resistant cancers. Here we show that N6-methyladenosine (m6A) mRNA demethylation by fat mass and obesity-associated protein (FTO) increases melanoma growth and decreases response to anti-PD-1 blockade ...
Aplin, Andrew E., Cui, Yan-Hong, Deng, Yu, He, Chuan, He, Yu-Ying, Hwang, Seungmin, Lu, Zhike, Park, Gayoung, Shah, Palak, Wei, Jiangbo, Yang, Seungwon   +10 more
core   +1 more source

The usefulness of c-Kit in the immunohistochemical assessment of melanocytic lesions [PDF]

, 2011
C-Kit (CD117), the receptor for the stem cell factor, a growth factor for melanocyte migra- tion and proliferation, has shown differential immunostaining in various benign and malig- nant melanocytic lesions. The purpose of this study is to compare c-Kit
Atzori L, Bianco P, Cabras S, Castellanos ME, Difelice E, Faa G, Ferreli C, Mulas P, Nemolato S, Pilloni L   +9 more
core   +1 more source