Results 81 to 90 of about 458,085 (304)

XXIX Italian Melanoma Intergroup National Congress | 29 September - 1 October 2023, Naples (Italy)

Dermatology Reports
s from the Italian Melanoma Intergroup (IMI) XXIX National ...
Italian Melanoma Intergroup (IMI)
doaj   +1 more source

Association of MC1R Variants and host phenotypes with melanoma risk in CDKN2A mutation carriers: a GenoMEL study [PDF]

, 2010
<p><b>Background</b> Carrying the cyclin-dependent kinase inhibitor 2A (CDKN2A) germline mutations is associated with a high risk for melanoma. Penetrance of CDKN2A mutations is modified by pigmentation characteristics, nevus phenotypes,
Affleck, P, Aguilera, P, Al\uf3s, L, Ancero, A, Arcangeli, F, Argu\ueds, P, Avril, Mf, Avril, Mf, Azizi, E, Badenas, C, Barrett, Jh, Battistuzzi, L, Bergman, W, Bergman, W, Bertazzi, Pa, BIANCHI-SCARR\uc0, G, Bianhi-Scarr\ue0, G, Bishop, Dt, Bishop, Dt, Borg, \uc5, BRESSAC-DE PAILLERETS, B, Bressac-de Paillerets, B, Bruno, W, Bruno, W., Butille, Ja, Calista, D, Calista, D, Campo, A, Capirossi, D, Carrera, C, Carrera, C, Castel, T, Cervera, R, Chan, M, Chaudru, V, Chaudru, V, Conill, C, Corda, E, Cuellar, F, de Lichy, M, Demenais, F, Duffy, Dl, Elder, D, Elder, De, Gabriel, D, Gargiulo, S, Ghiorzo, P, Ghiorzo, P., Gillanders, E, Gliori, S, Goldstein, Am, Goldstein, Am, Gonzalez, M, Gruis, N, Gruis, Na, H\uf6iom, V, H\uf6iom, V, Hansson, J, Hansson, J, Harbst, K, Harland, M, Harland, M, Harrison, J, Haynes, S, Hayward, Nk, Hayward, Nk, Hogg, D, Hogg, D, Holland, Ea, Holland, Ea., Iglesias, P, Iles, Mm, Ingvar, C, Ingvar, C, J\uf6nsson, G, Jeannin, P, Kanetsky, P, Kanetsky, Pa, Karpavicius, B, Kefford, Rf, Kukalizch, K, Landi, G, Landi, Mt, Landi, Mt, Lang, J, Lang, Jm, Leake, S, Lesueur, F, Lind\ue9n, D, Loo, Jc, M\ue5sb\ue4ck, A, Macgregor, S, Mack, T, Mackie, R, Mackie, Rm, Malvehy, J, Mann, Gj, Mann, Gj, Marti-Laborda, R, Martin, Ng, Maubec, E, Melanoma Genetics Consortium: Demenais, F, Mila, M, Ming, M, Ming, Me, Minghetti, P, Mitra, N, Mohamdi, H, Mohamdi, H, Montgomery, Gw, Nasti, S, NEWTON BISHOP JA,, Newton Bishop JA,, Nielsen, K, Njauw, Cj, Njauw, Cn, Ogbah, Z, Olsson, H, Olsson, H, Origone, P, Palmer, J, Palou, J, Parossian, S, Pastorino, L, Pastorino, L, Puig, S, Puig, S, Queirolo, P, RANDERSON-MOOR, J, Randerson-Moor, J, Ruffin, A, Rull, R, S\ue1nchez, M, Schmid, H, Stark, M, Taylor, Jc, Taylor, Y, Tesema, L, Tsao, H, Tsao, H, Tucker, Ma, Tucker, Ma, Tuominen, R, VAN BELLE, P, Van Belle, P, VAN DER VELDEN, P, van der Velden, P, van Mourik, L, van Nieuwpport FA,, Vidal-Sicart, S, Vilalta, A, Vilella, R, Whiteman, Dc, Whittaker, L, Yang, Xr, Yang, Xr   +155 more
core   +2 more sources

Vitamins and Melanoma [PDF]

Cancers, 2015
A tremendous amount of information was published over the past decades in relation to the role of vitamins in various neoplastic diseases. In particular, several studies showed an inverse relationship between selected vitamins intake and cancer risk.
Russo, Irene, Caroppo, Francesca, ALAIBAC, MAURO SALVATORE ALESSANDRO   +2 more
openaire   +3 more sources

Impact of molecular diagnostics and targeted cancer therapy on patient outcomes (MODIFY): a retrospective study of the implementation of precision oncology

Molecular Oncology, EarlyView.
The authors conducted a retrospective study of 94 patients with advanced cancer who underwent next‐generation sequencing (NGS) gene panel analysis and received targeted treatments when applicable. Results further support evidence indicating that molecular profiling provides clinical benefit.
Michaël Dang, Anna Schritz, Nikolai Goncharenko, Guy Berchem   +3 more
wiley   +1 more source

KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

Molecular Oncology, EarlyView.
We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock, Lina Benzien, Sandra Lange, Maja Huehns, Alexandra Runge, Catrin Roolf, Anett Sekora, Gudrun Knuebel, Hugo Murua Escobar, Christian Junghanss, Anna Richter   +10 more
wiley   +1 more source

Serum CEACAM1 Elevation Correlates with Melanoma Progression and Failure to Respond to Adoptive Cell Transfer Immunotherapy

Journal of Immunology Research, 2015
Malignant melanoma is a devastating disease whose incidences are continuously rising. The recently approved antimelanoma therapies carry new hope for metastatic patients for the first time in decades.
R. Ortenberg, S. Sapoznik, D. Zippel, R. Shapira-Frommer, O. Itzhaki, A. Kubi, D. Zikich, M. J. Besser, J. Schachter, G. Markel   +9 more
doaj   +1 more source

Understanding signaling cascades in melanoma [PDF]

, 2008
Understanding regulatory pathways involved in melanoma development and progression has advanced significantly in recent years. It is now appreciated that melanoma is the result of complex changes in multiple signaling pathways that affect growth control,
Akslen L. A., Berger A. J., Berking C., Bhoumik A., Bhoumik A., Chen X., Claffey K. P., Collisson E. A., Coppock D. L., Dahia P. L. M., Dhawan P., Dorsky R. I., Ehebauer M., Eisenmann K. M., Genersch E., Goding C. R., Goodall J., Gorden A., Guldberg P., Gurzov E. N., Herbst R. A., Hingorani S. R., Hughes M. J., Huguier S., Iozzo R. V., Jonsson M., Jorgensen K., Karin M., Kennedy N. J., Kumar R., Lacal P. M., Li N., Maeno K., Meyskens F. L., Miller J. R., Miyazono K., Niu G., Okuyama R., Omholt K., Park B. K., Piek E., Qin J.-Z., Rangaswami H., Rimm D. L., Rofstad E. K., Satyamoorthy K., Soldatencov V. A., Stewart F. A., Tago K.-i., Thomson J. A., Tokita T., Tsai E. Y., Tsao H., van Elsas A., Wu M., Yang J., Yang J., Yang Y. M., Zhou X. P.   +58 more
core   +1 more source

Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia

Molecular Oncology, EarlyView.
CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar, Shima Shahbaz, Anthea C. Peters, Spencer B. Gibson, Shokrollah Elahi   +4 more
wiley   +1 more source

Detector-SegMentor Network for Skin Lesion Localization and Segmentation [PDF]

arXiv, 2020
Melanoma is a life-threatening form of skin cancer when left undiagnosed at the early stages. Although there are more cases of non-melanoma cancer than melanoma cancer, melanoma cancer is more deadly. Early detection of melanoma is crucial for the timely diagnosis of melanoma cancer and prohibit its spread to distant body parts.
arxiv  

A Clinically Inspired Approach for Melanoma classification [PDF]

arXiv, 2021
Melanoma is a leading cause of deaths due to skin cancer deaths and hence, early and effective diagnosis of melanoma is of interest. Current approaches for automated diagnosis of melanoma either use pattern recognition or analytical recognition like ABCDE (asymmetry, border, color, diameter and evolving) criterion.
arxiv