Results 11 to 20 of about 4,663 (179)
PLoS Biology, 2006 A new melanopsin gene, identified in fish, bird, and amphibian genomes, is the true ortholog of the melanopsin gene previously described in mammals.
James Bellingham +9 more
doaj +3 more sources
Evolution of melanopsin photoreceptors: discovery and characterization of a new melanopsin in nonmammalian vertebrates. [PDF]
PLoS Biology, 2006 In mammals, the melanopsin gene (Opn4) encodes a sensory photopigment that underpins newly discovered inner retinal photoreceptors. Since its first discovery in Xenopus laevis and subsequent description in humans and mice, melanopsin genes have been ...
James Bellingham +9 more
doaj +7 more sources
Spectral Tuning in Mammalian Melanopsins. [PDF]
Mol Biol EvolAbstract Melanopsin is a light-sensitive G-protein coupled receptor responsible for essential visual and non-visual light-mediated behaviors in mammals. Human melanopsin shows maximal sensitivity (λmax) in the blue region of the spectrum (∼480 nm), and available evidence suggests that this spectral sensitivity may be retained across ...
McDowell RJ +3 more
europepmc +4 more sources
Current Biology, 2002 What are opsins? Opsins are generally considered members of the superfamily of G-protein coupled receptors. But not all opsins activate a G-protein. Their distinguishing features are a 7 transmembrane α-helical structure, and an ability to bind a vitamin A chromophore, retinaldehyde, using a lysine in the 7th α-helix.
Foster, Russell, Bellingham, James
openaire +3 more sources
Melanopsin expression in the cornea [PDF]
Visual Neuroscience, 2018 AbstractA unique class of intrinsically photosensitive retinal ganglion cells in mammalian retinae has been recently discovered and characterized. These neurons can generate visual signals in the absence of inputs from rods and cones, the conventional photoreceptors in the visual system. These light sensitive ganglion cells (mRGCs) express the non-rod,
Delwig, Anton +11 more
openaire +6 more sources
Melanopsin: The Tale of the Tail [PDF]
Neuron, 2016 In this issue of Neuron, Mure et al. (2016) demonstrate that two mechanisms-phosphorylation of a C-terminal intracellular region, and mechanism involving the whole of the C terminus-oppositely shape the kinetics and sensitivity of the nonvisual photoreceptor melanopsin.
Russell N, Van Gelder, Ethan D, Buhr
openaire +2 more sources
Vision: Melanopsin as a Raumgeber [PDF]
Current Biology, 2017 Two new studies show that neural systems receiving inputs from the melanopsin-containing retinal ganglion cells encode spatial information and therefore see the world in more detail than previously thought.
Spitschan, M, Aguirre, G
openaire +3 more sources
Light adaptation characteristics of melanopsin
Vision Research, 2021 Following photopigment bleaching, the rhodopsin and cone-opsins show a characteristic exponential regeneration in the dark with a photocycle dependent on the retinal pigment epithelium. Melanopsin pigment regeneration in animal models requires different pathways to rods and cones.
Pant, Mukund +3 more
openaire +3 more sources
PLoS ONE, 2012 Melanopsin is a photosensitive cell protein involved in regulating circadian rhythms and other non-visual responses to light. The melanopsin gene family is represented by two paralogs, OPN4x and OPN4m, which originated through gene duplication early in ...
Rui Borges +5 more
doaj +1 more source
PLoS ONE, 2020 Melanopsin is a visual pigment expressed in a small subset of ganglion cells in the mammalian retina known as intrinsically photosensitive retinal ganglion cells (ipRGCs) and is implicated in regulating non-image forming functions such as circadian ...
Juan C Valdez-Lopez +4 more
doaj +1 more source