Results 31 to 40 of about 6,987 (212)

A Review of Silent Substitution Devices for Melanopsin Stimulation in Humans

Photonics, 2020
One way to study the specific response of the non-visual melanopsin photoreceptors of the human eye is to silence the response of cones and rods. Melanopsin photoreceptors (ipRGC), highlighted in the early 2000s, are intimately linked to the circadian ...
Vincent Conus, Martial Geiser
doaj   +1 more source

Targeted destruction of photosensitive retinal ganglion cells with a saporin conjugate alters the effects of light on mouse circadian rhythms.

PLoS ONE, 2008
Non-image related responses to light, such as the synchronization of circadian rhythms to the day/night cycle, are mediated by classical rod/cone photoreceptors and by a small subset of retinal ganglion cells that are intrinsically photosensitive ...
Didem Göz, Keith Studholme, Douglas A Lappi, Mark D Rollag, Ignacio Provencio, Lawrence P Morin   +5 more
doaj   +1 more source

Dissecting a role for melanopsin in behavioural light aversion reveals a response independent of conventional photoreception.

PLoS ONE, 2010
Melanopsin photoreception plays a vital role in irradiance detection for non-image forming responses to light. However, little is known about the involvement of melanopsin in emotional processing of luminance.
Ma'ayan Semo, Carlos Gias, Ahmad Ahmado, Eriko Sugano, Annette E Allen, Jean M Lawrence, Hiroshi Tomita, Peter J Coffey, Anthony A Vugler   +8 more
doaj   +1 more source

Dopamine modulates the retinal clock through melanopsin-dependent regulation of cholinergic waves during development

BMC Biology, 2023
Background The mammalian retina contains an autonomous circadian clock that controls various aspects of retinal physiology and function, including dopamine (DA) release by amacrine cells. This neurotransmitter plays a critical role in retina development,
Chaimaa Kinane, Hugo Calligaro, Antonin Jandot, Christine Coutanson, Nasser Haddjeri, Mohamed Bennis, Ouria Dkhissi-Benyahya   +6 more
doaj   +1 more source

Small molecule antagonists of melanopsin-mediated phototransduction [PDF]

, 2013
Melanopsin, expressed in a subset of retinal ganglion cells, mediates behavioral adaptation to ambient light and other non-image forming photic responses.
Kenneth A Jones, Jones, Kenneth A., Sollars, Patricia J., Quansheng Zhu, Mure, Ludovic S., Patricia J Sollars, Hatori, Megumi, Artymyshyn, Roman, Marzabadi, Mohammad, Huailing Zhong, Satchidananda Panda, Pickard, Gary E., Mohammad Marzabadi, Gary E Pickard, Sang-Phyo Hong, Hartwick, Andrew T. E., Panda, Satchidananda, Bramley, Jayne R., Sprouse, Jeffrey, Megumi Hatori, Jayne R Bramley, Jeffrey Sprouse, Zhu, Quansheng, Ludovic S Mure, Hong, Sang-Phyo, Andrew T E Hartwick, Zhong, Huailing, Roman Artymyshyn   +27 more
core   +1 more source

G-Protein Coupled Receptor Kinase 2 Minimally Regulates Melanopsin Activity in Intrinsically Photosensitive Retinal Ganglion Cells.

PLoS ONE, 2015
Phosphorylation is a primary modulator of mammalian G-protein coupled receptor (GPCR) activity. The GPCR melanopsin is the photopigment of intrinsically photosensitive retinal ganglion cells (ipRGCs) in the mammalian retina. Recent evidence from in vitro
Timothy J Sexton, Russell N Van Gelder
doaj   +1 more source

Melanopsin: An opsin in melanophores, brain, and eye [PDF]

Proceedings of the National Academy of Sciences, 1998
We have identified an opsin, melanopsin, in photosensitive dermal melanophores of Xenopus laevis . Its deduced amino acid sequence shares greatest homology with cephalopod opsins. The predicted secondary structure of melanopsin indicates the presence of a long cytoplasmic tail with multiple ...
Provencio, I., Jiang, G., Grip, W.J. de, PärHayes, W., Rollag, M.D.   +4 more
openaire   +3 more sources

Melanopsin—β2-adrenergic receptor and melanopsin—Angiotensin II type-1a receptor chimeric mutants display different deactivation kinetics.

, 2020
In both chimeric constructs, melanopsin was truncated at residue 387, which is right before P-II. (A) 2D schematic of melanopsin-β2-adrenergic receptor chimera, melanopsin residues are represented in blue and β2AR residues are represented in red ...
Elelbin A. Ortiz (8655285), Phyllis R. Robinson (204369), Sahil Gulati (4470151), Krzysztof Palczewski (67410), Juan C. Valdez-Lopez (8655282)   +4 more
core   +1 more source

Melanopsin signalling in mammalian iris and retina [PDF]

Nature, 2011
Non-mammalian vertebrates have an intrinsically photosensitive iris and thus a local pupillary light reflex (PLR). In contrast, it is thought that the PLR in mammals generally requires neuronal circuitry connecting the eye and the brain. Here we report that an intrinsic component of the PLR is in fact widespread in nocturnal and crepuscular mammals. In
Xue, T., Do, M. T. H., Riccio, A., Jiang, Z., Hsieh, J., Wang, H. C., Merbs, S. L., Welsbie, D. S., Yoshioka, T., Weissgerber, P., Stolz, S., Flockerzi, V., Freitchel, M., Simon, M. I., Clapham, D. E., Yau, K.-W.   +15 more
openaire   +3 more sources

Melanopsin-mediated post-illumination pupil response in the peripheral retina [PDF]

, 2016
Intrinsically photosensitive retinal ganglion cells (ipRGCs)\ud regulate pupil size by integrating extrinsic rod and cone\ud signals with intrinsic melanopsin-mediated phototransduction.
Zele, Andrew J., Feigl, Beatrix, Joyce, Daniel S.   +2 more
core   +1 more source