Results 31 to 40 of about 4,663 (179)

Melanopsin signalling in mammalian iris and retina [PDF]

Nature, 2011
Non-mammalian vertebrates have an intrinsically photosensitive iris and thus a local pupillary light reflex (PLR). In contrast, it is thought that the PLR in mammals generally requires neuronal circuitry connecting the eye and the brain. Here we report that an intrinsic component of the PLR is in fact widespread in nocturnal and crepuscular mammals. In
Xue, T., Do, M. T. H., Riccio, A., Jiang, Z., Hsieh, J., Wang, H. C., Merbs, S. L., Welsbie, D. S., Yoshioka, T., Weissgerber, P., Stolz, S., Flockerzi, V., Freitchel, M., Simon, M. I., Clapham, D. E., Yau, K.-W.   +15 more
openaire   +3 more sources

Loss of gq/11 genes does not abolish melanopsin phototransduction.

PLoS ONE, 2014
In mammals, a subset of retinal ganglion cells (RGCs) expresses the photopigment melanopsin, which renders them intrinsically photosensitive (ipRGCs). These ipRGCs mediate various non-image-forming visual functions such as circadian photoentrainment and ...
Kylie S Chew, Tiffany M Schmidt, Alan C Rupp, Paulo Kofuji, Jeffrey M Trimarchi   +4 more
doaj   +1 more source

M1 Intrinsically Photosensitive Retinal Ganglion Cells Integrate Rod and Melanopsin Inputs to Signal in Low Light

Cell Reports, 2019
Summary: Light influences various behaviors and physiological processes that occur outside of our conscious perception, including circadian photoentrainment, sleep, and even learning and mood.
Seul Ki Lee, Takuma Sonoda, Tiffany M. Schmidt   +2 more
doaj   +1 more source

Melanopsin contributions to irradiance coding in the thalamo-cortical visual system.

PLoS Biology, 2010
Photoreception in the mammalian retina is not restricted to rods and cones but extends to a subset of retinal ganglion cells expressing the photopigment melanopsin (mRGCs).
Timothy M Brown, Carlos Gias, Megumi Hatori, Sheena R Keding, Ma'ayan Semo, Peter J Coffey, John Gigg, Hugh D Piggins, Satchidananda Panda, Robert J Lucas   +9 more
doaj   +1 more source

Adult Expression of Tbr2 Is Required for the Maintenance but Not Survival of Intrinsically Photosensitive Retinal Ganglion Cells

Frontiers in Cellular Neuroscience, 2022
Retinal ganglion cells expressing the photopigment melanopsin are intrinsically photosensitive (ipRGCs). ipRGCs regulate subconscious non-image-forming behaviors such as circadian rhythms, pupil dilation, and light-mediated mood.
Sadaf Abed, Andreea Reilly, Sebastian J. Arnold, David A. Feldheim   +3 more
doaj   +1 more source

Melanopsin activates divergent phototransduction pathways in intrinsically photosensitive retinal ganglion cell subtypes

eLife, 2023
Melanopsin signaling within intrinsically photosensitive retinal ganglion cell (ipRGC) subtypes impacts a broad range of behaviors from circadian photoentrainment to conscious visual perception.
Ely Contreras, Jacob D Bhoi, Takuma Sonoda, Lutz Birnbaumer, Tiffany M Schmidt   +4 more
doaj   +1 more source

An Implantable Optogenetics‐Engineered Hydrogel for Amelioration of Rheumatoid Arthritis through Light‐Controlled Metabolic Reprogramming of Synovial Macrophages

Advanced Science, EarlyView.
An implantable hydrogel is designed to enable in situ and on‐demand secretion of GLP‐1 in synovium through blue light irradiation to activate GLP‐1R/HK2/VDAC1 pathway for upregulating tricarboxylic acid cycle and oxidative phosphorylation in macrophage, facilitating tissue repair and bone erosion recovery.
Dahai Hu, Yaru Sun, Qi Lu, Yi Zhang, Jieruo Li, Huige Hou, Huajun Wang, Hui Tang, Yunsong Zhang, Xiaofei Zheng, Qingsong Mei   +10 more
wiley   +1 more source

Mixed Palettes of Melanopsin Phototransduction [PDF]

Cell, 2018
Animal photoreceptors divide into two fundamental classes, ciliary and rhabdomeric. Jiang and colleagues demonstrate that this boundary is disregarded by the intrinsically photosensitive retinal ganglion cells of mammals. These neurons draw from phototransduction mechanisms of both classes, enriching the signals that they produce to drive a diversity ...
openaire   +2 more sources

Melanopsin (Opn4) is an oncogene in cutaneous melanoma

Communications Biology, 2022
AbstractThe search for new therapeutical targets for cutaneous melanoma and other cancers is an ongoing task. We expanded this knowledge by evaluating whether opsins, light- and thermo-sensing proteins, could display tumor-modulatory effects on melanoma cancer.
Leonardo Vinícius Monteiro de Assis, José Thalles Lacerda, Maria Nathália Moraes, Omar Alberto Domínguez-Amorocho, Gabriela Sarti Kinker, Davi Mendes, Matheus Molina Silva, Carlos Frederico Martins Menck, Niels Olsen Saraiva Câmara, Ana Maria de Lauro Castrucci   +9 more
openaire   +3 more sources

From blue light to clock genes in zebrafish ZEM-2S cells.

PLoS ONE, 2014
Melanopsin has been implicated in the mammalian photoentrainment by blue light. This photopigment, which maximally absorbs light at wavelengths between 470 and 480 nm depending on the species, is found in the retina of all classes of vertebrates so far ...
Bruno C R Ramos, Maria Nathália C M Moraes, Maristela O Poletini, Leonardo H R G Lima, Ana Maria L Castrucci   +4 more
doaj   +1 more source