Results 71 to 80 of about 4,663 (179)

Traceless Regulation of Genetic Circuitry

Advanced Science, Volume 13, Issue 10, 18 February 2026.
Energy‐based, as opposed to molecular, control offers unprecedented improvements in key circuit parameters. This review summarizes the fundamentals of such traceless switches, categorizes them by trigger modalities, and compares and contrasts distinct advantages as well as shortcomings of each kind.
Gokberk Unal, Martin Fussenegger
wiley   +1 more source

Broad Epigenetic Shifts in the Aging Drosophila Retina Contribute to Its Altered Diurnal Rhythmic Transcriptome

Aging Cell, Volume 25, Issue 2, February 2026.
As flies age, their photoreceptor transcriptome is extensively reprogrammed, with about 40% of genes undergoing rhythmic expression changes. These transcriptional changes are accompanied by altered RNA Polymerase II occupancy, chromatin accessibility, and H3K4 methylation, without major changes to the occupancy of the core clock transcription factors ...
Sarah E. McGovern, Gaoya Meng, Makayla N. Marlin, Sophia A. Pruitt, Vikki M. Weake   +4 more
wiley   +1 more source

Melanopsin Stimulation Modulates Blackness Induction

Color Research &Application, Volume 51, Issue 1, January/February 2026.
Spectral power distributions of (A) the surround and (B) the center stimuli. The stimulus intensity to melanopsin cells of the surround was modulated from 0.51 to 1.21 (#1; 0.51, #2; 0.65, #3; 0.78, #4; 0.93, #5; 1.09, #6; 1.21, #7; 0.51, #8; 0.67, #9; 0.95, #10; 1.21) in the melanopic/photopic ratio (M/P ratio) under both the 700 cd/m2 and 375 cd/m2 ...
Masahiko Yamakawa, Katsunori Okajima, John S. Werner   +2 more
wiley   +1 more source

Reduced Neuronal Self‐Avoidance in Mouse Starburst Amacrine Cells With Only One Pcdhg Isoform

Developmental Neurobiology, Volume 86, Issue 1, January 2026.
ABSTRACT The clustered protocadherins (cPcdhs) are a family of ∼60 homophilic cell adhesion molecules expressed across three gene clusters (Pcdha, Pcdhb, and Pcdhg) with a variety of essential roles in the developing nervous system. Some of these roles rely on specific isoforms, whereas others are more consistent with a model of isoform redundancy or a
Cathy M. McLeod, Seoyoung Son, Muhammad Nazmul Haque, Camille M. Hanes, Andrew M. Garrett   +4 more
wiley   +1 more source

Melanopsin DNA aptamers can regulate input signals of mammalian circadian rhythms by altering the phase of the molecular clock

Frontiers in Neuroscience
DNA aptamers can bind specifically to biomolecules to modify their function, potentially making them ideal oligonucleotide therapeutics. Herein, we screened for DNA aptamer of melanopsin (OPN4), a blue-light photopigment in the retina, which plays a key ...
Kazuo Nakazawa, Kazuo Nakazawa, Minako Matsuo, Yo Kikuchi, Yo Kikuchi, Yoshihiro Nakajima, Rika Numano, Rika Numano   +7 more
doaj   +1 more source

Melanopsin in the human and chicken choroid

Experimental Eye Research
The choroid embedded in between retina and sclera is essential for retinal photoreceptor nourishment, but is also a source of growth factors in the process of emmetropization that converts retinal visual signals into scleral growth signals. Still, the exact control mechanisms behind those functions are enigmatic while circadian rhythms are involved ...
Christian Platzl, Alexandra Kaser-Eichberger, Andrea Trost, Clemens Strohmaier, Richard Stone, Debora Nickla, Falk Schroedl   +6 more
openaire   +2 more sources

Melanopsin-Driven Pupil Response and Light Exposure in Non-seasonal Major Depressive Disorder

Frontiers in Neurology, 2018
Background: Melanopsin-expressing intrinsically photosensitive Retinal Ganglion Cells (ipRGCs) signal non-imaging forming effects of environmental light for circadian phoentrainment, the pupil light reflex, and mood regulation.
Beatrix Feigl, Beatrix Feigl, Beatrix Feigl, Govinda Ojha, Govinda Ojha, Leanne Hides, Andrew J. Zele, Andrew J. Zele   +7 more
doaj   +1 more source

Measuring and using light in the melanopsin age

Trends in Neurosciences, 2014
Light is a potent stimulus for regulating circadian, hormonal, and behavioral systems. In addition, light therapy is effective for certain affective disorders, sleep problems, and circadian rhythm disruption. These biological and behavioral effects of light are influenced by a distinct photoreceptor in the eye, melanopsin-containing intrinsically ...
Lucas, Robert J, Peirson, Stuart N, Berson, David M, Brown, Timothy M, Cooper, Howard M, Czeisler, Charles A, Figueiro, Mariana G, Gamlin, Paul D, Lockley, Steven W, O'Hagan, John B, Price, Luke L A, Provencio, Ignacio, Skene, Debra J, Brainard, George C   +13 more
openaire   +4 more sources

Rhodopsin and Melanopsin Contributions to the Early Redilation Phase of the Post-Illumination Pupil Response (PIPR).

PLoS ONE, 2016
Melanopsin expressing intrinsically photosensitive Retinal Ganglion Cells (ipRGCs) entirely control the post-illumination pupil response (PIPR) from 6 s post-stimulus to the plateau during redilation after light offset.
Prakash Adhikari, Beatrix Feigl, Andrew J Zele   +2 more
doaj   +1 more source

Blue light activates pulvinar nuclei in longstanding idiopathic photophobia: A case report

NeuroImage: Clinical, 2019
Numerous pathologies can contribute to photophobia. When considering light transduction alone, photophobia may be triggered through melanopsin pathways (non-image forming), rod and cone pathways (image-forming), or some combination of the two.
Athanasios Panorgias, Danielle Lee, Katie E. Silva, David Borsook, Eric A. Moulton   +4 more
doaj   +1 more source