Results 81 to 90 of about 4,663 (179)

Vision: Melanopsin and the Pharmacology of Photons

Current Biology, 2016
Using a targeted chemogenetic approach, a new study provides evidence for a unique pathway for neural processing of light information from melanopsin ganglion cells. These results suggest how light can have both alerting and sleep-promoting effects in mice.
openaire   +2 more sources

Evolution and functional characterisation of melanopsins in a deep-sea chimaera (elephant shark, Callorhinchus milii).

PLoS ONE, 2012
Non-visual photoreception in mammals is primarily mediated by two splice variants that derive from a single melanopsin (OPN4M) gene, whose expression is restricted to a subset of retinal ganglion cells.
Wayne I L Davies, Boon-Hui Tay, Lei Zheng, Janine A Danks, Sydney Brenner, Russell G Foster, Shaun P Collin, Mark W Hankins, Byrappa Venkatesh, David M Hunt   +9 more
doaj   +1 more source

NMDA Receptors Contribute to Retrograde Synaptic Transmission from Ganglion Cell Photoreceptors to Dopaminergic Amacrine Cells

Frontiers in Cellular Neuroscience, 2017
Recently, a line of evidence has demonstrated that the vertebrate retina possesses a novel retrograde signaling pathway. In this pathway, phototransduction is initiated by the photopigment melanopsin, which is expressed in a small population of retinal ...
Lei-Lei Liu, Nathan J. Spix, Dao-Qi Zhang   +2 more
doaj   +1 more source

In-silico predicted mouse melanopsins with blue spectral shifts deliver efficient subcellular signaling

Cell Communication and Signaling
Melanopsin is a photopigment belonging to the G Protein-Coupled Receptor (GPCR) family expressed in a subset of intrinsically photosensitive retinal ganglion cells (ipRGCs) and responsible for a variety of processes.
Dhanushan Wijayaratna, Filippo Sacchetta, Laura Pedraza-González, Francesca Fanelli, Tomohiro Sugihara, Mitsumasa Koyanagi, Senuri Piyawardana, Kiran Ghotra, Waruna Thotamune, Akihisa Terakita, Massimo Olivucci, Ajith Karunarathne   +11 more
doaj   +1 more source

Illumination by short-wavelength light inside the blind spot decreases light detectability

iScience
Summary: Although the optic disk corresponding to the blind spot contains no classical photoreceptors, it contains photopigment melanopsin. To clarify whether melanopsin is involved in light detection, we conducted detection tasks for light stimuli ...
Marina Saito, Kentaro Miyamoto, Ikuya Murakami   +2 more
doaj   +1 more source

Determining Light Intensity, Timing and Type of Visible and Circadian Light From an Ambulatory Circadian Monitoring Device

Frontiers in Physiology, 2019
During last decades, the way of life in modern societies has deeply modified the temporal adjustment of the circadian system, mainly due to the inappropriate use of artificial lighting and the high prevalence of social jet-lag.
Raquel Arguelles-Prieto, Maria-Angeles Bonmati-Carrion, Maria-Angeles Bonmati-Carrion, Maria Angeles Rol, Maria Angeles Rol, Juan Antonio Madrid, Juan Antonio Madrid   +6 more
doaj   +1 more source

Pupil responses to hidden photoreceptor-specific modulations in movies.

PLoS ONE, 2019
Under typical daytime light levels, the human pupillary light response (PLR) is driven by the activity of the L, M, and S cones, and melanopsin expressed in the so-called intrinsically photosensitive retinal ganglion cells (ipRGCs).
Manuel Spitschan, Marina Gardasevic, Franck P Martial, Robert J Lucas, Annette E Allen   +4 more
doaj   +1 more source

Inducible ablation of melanopsin-expressing retinal ganglion cells reveals their central role in non-image forming visual responses.

PLoS ONE, 2008
Rod/cone photoreceptors of the outer retina and the melanopsin-expressing retinal ganglion cells (mRGCs) of the inner retina mediate non-image forming visual responses including entrainment of the circadian clock to the ambient light, the pupillary light
Megumi Hatori, Hiep Le, Christopher Vollmers, Sheena Racheal Keding, Nobushige Tanaka, Thorsten Buch, Ari Waisman, Christian Schmedt, Timothy Jegla, Satchidananda Panda   +9 more
doaj   +1 more source

Exploring the relationship between melanopsin gene variants, sleep, and markers of brain health

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Melanopsin is a photopigment with roles in mediating sleep and circadian‐related processes, which are often disrupted in Alzheimer's disease (AD). Melanopsin also impacts cognition and synaptogenesis. This study investigated the associations
Ayeisha Milligan Armstrong, Eleanor O'Brien, Tenielle Porter, Vincent Dore, Pierrick Bourgeat, Paul Maruff, Christopher C. Rowe, Victor. L. Villemagne, Stephanie R. Rainey‐Smith, Simon M. Laws, the AIBL Research Group   +10 more
doaj   +1 more source

Excitación melanopsinica en condiciones de iluminación natural y artificial

Anales (Asociación Física Argentina), 2018
Biological adaptation to sunlight evolved over millions of years. The intrusion of artificial lighting has disrupted this relationship with the natural environment.
O. U. Preciado, L. A. Issolio, E. Manzano, E. Colombo, P. A. Barrionuevo   +4 more
doaj