Multimodal investigation of melanopsin retinal ganglion cells in Alzheimer's disease [PDF]
Annals of Clinical and Translational Neurology, 2023 Objective In Alzheimer's disease (AD), the presence of circadian dysfunction is well‐known and may occur early in the disease course. The melanopsin retinal ganglion cell (mRGC) system may play a relevant role in contributing to circadian dysfunction. In
Chiara La Morgia +21 more
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Synaptic Specializations of Melanopsin-Retinal Ganglion Cells in Multiple Brain Regions Revealed by Genetic Label for Light and Electron Microscopy [PDF]
Cell Reports, 2019 Summary: The form and synaptic fine structure of melanopsin-expressing retinal ganglion cells, also called intrinsically photosensitive retinal ganglion cells (ipRGCs), were determined using a new membrane-targeted version of a genetic probe for ...
Keun-Young Kim +17 more
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Distribution of melanopsin positive neurons in pigmented and albino mice: Evidence for melanopsin interneurons in the mouse retina [PDF]
Frontiers in Neuroanatomy, 2014 Here we have studied the population of intrinsically photosensitive retinal ganglion cells (ipRGCs) in adult pigmented and albino mice. Our data show that although pigmented (C57Bl/6) and albino (Swiss) mice have a similar total number of ipRGCs, their ...
Francisco Javier Valiente-Soriano +8 more
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Light, Sound, and Melatonin: Investigating Multisensory Pathways for Visual Restoration [PDF]
MedicinaMultisensory integration is fundamental for coherent perception and interaction with the environment. While cortical mechanisms of multisensory convergence are well studied, emerging evidence implicates specialized retinal ganglion cells—particularly ...
Dario Rusciano
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Melanopsin-mediated image statistics from natural and human-made environments [PDF]
Scientific ReportsMelanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs) play a critical role in regulating physiological and behavioral responses to light.
Pablo A. Barrionuevo +1 more
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Blue light stimulation of the blind spot in human: from melanopsin to clinically relevant biomarkers of myopia [PDF]
Bioelectronic MedicineThe protective effects of time spent outdoors emphasize the major role of daylight in myopia. Based on the pathophysiology of myopia, the impact of blue light stimulation on the signaling cascade, from melanopsin at the blind spot to clinically relevant ...
Ana Amorim-de-Sousa +9 more
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Dendritic Morphology of Caudal Periaqueductal Gray Projecting Retinal Ganglion Cells in Mongolian Gerbil (Meriones unguiculatus) [PDF]
, 2014 In this study we investigated the morphological features of the caudal periaqueductal gray (cPAG)-projecting retinal ganglion cells (RGCs) in Mongolian gerbils using retrograde labeling, in vitro intracellular injection, confocal microscopy and three ...
Cui, Q, Pu, M, Ren, C, So, KF
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Melanopic stimulation does not alter psychophysical threshold sensitivity for luminance flicker
Scientific Reports, 2021 In addition to the rod and cone photoreceptors the retina contains intrinsically photosensitive retinal ganglion cells (ipRGCs). These cells express the photopigment melanopsin and are known to be involved in reflexive visual functions such as pupil ...
Joris Vincent +3 more
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BMC Biology, 2023 Background The mammalian retina contains an autonomous circadian clock that controls various aspects of retinal physiology and function, including dopamine (DA) release by amacrine cells. This neurotransmitter plays a critical role in retina development,
Chaimaa Kinane +6 more
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The multistable melanopsins of mammals
Frontiers in Ophthalmology, 2023 Melanopsin is a light-activated G protein coupled receptor that is expressed widely across phylogeny. In mammals, melanopsin is found in intrinsically photosensitive retinal ganglion cells (ipRGCs), which are especially important for “non-image” visual ...
Alan J. Emanuel, Michael Tri H. Do
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