Results 11 to 20 of about 7,378 (211)

Melanopsin-expressing retinal ganglion cells are resistant to cell injury, but not always [PDF]

Mitochondrion, 2017
Melanopsin retinal ganglion cells (mRGCs) are intrinsically photosensitive RGCs deputed to non-image forming functions of the eye such as synchronization of circadian rhythms to light-dark cycle.
Carelli, Valerio, Georg, Birgitte, Ghelli, Anna, Giordano, Carla, Hannibal, Jens, La Morgia, Chiara, Ross Cisneros, Fred N., Sadun, Alfredo A.   +7 more
core   +5 more sources

The injury resistant ability of melanopsin-expressing intrinsically photosensitive retinal ganglion cells [PDF]

Neuroscience, 2015
Neurons in the mammalian retina expressing the photopigment melanopsin have been identified as a class of intrinsically photosensitive retinal ganglion cells (ipRGCs).
Cui, Q, Pickard, GE, Ren, C, So, KF, Sollars, PJ   +4 more
core   +5 more sources

Mood, the Circadian System, and Melanopsin Retinal Ganglion Cells. [PDF]

Annu Rev Neurosci, 2017
The discovery of a third type of photoreceptors in the mammalian retina, intrinsically photosensitive retinal ganglion cells (ipRGCs), has had a revolutionary impact on chronobiology. We can now properly account for numerous non-vision-related functions of light, including its effect on the circadian system.
Lazzerini Ospri L, Prusky G, Hattar S.
europepmc   +4 more sources

Amplifying and ameliorating light avoidance in mice with photoreceptor targeting and calcitonin gene-related peptide sensitization. [PDF]

Headache
Abstract Objective The aim of this study was to determine the photoreceptor basis of light avoidance in mice and assess the effect of CGRP sensitization on this behavior. Background Prior studies have suggested that photophobia is mediated by a subset of retinal ganglion cells (RGCs) that contain melanopsin, making them intrinsically photosensitive ...
Kaiser EA, Cavanah A, Aguirre GK, Jensen FE.   +3 more
europepmc   +2 more sources

Melanopsin Retinal Ganglion Cells and Pupil: Clinical Implications for Neuro-Ophthalmology. [PDF]

Front Neurol, 2018
Melanopsin retinal ganglion cells (mRGCs) are intrinsically photosensitive RGCs that mediate many relevant non-image forming functions of the eye, including the pupillary light reflex, through the projections to the olivary pretectal nucleus. In particular, the post-illumination pupil response (PIPR), as evaluated by chromatic pupillometry, can be used
La Morgia C, Carelli V, Carbonelli M.
europepmc   +6 more sources

Melanopsin Retinal Ganglion Cells Regulate Cone Photoreceptor Lamination in the Mouse Retina. [PDF]

Cell Rep, 2018
Newborn neurons follow molecular cues to reach their final destination, but whether early life experience influences lamination remains largely unexplored. As light is among the first stimuli to reach the developing nervous system via intrinsically photosensitive retinal ganglion cells (ipRGCs), we asked whether ipRGCs could affect lamination in the ...
Tufford AR, Onyak JR, Sondereker KB, Lucas JA, Earley AM, Mattar P, Hattar S, Schmidt TM, Renna JM, Cayouette M.   +9 more
europepmc   +5 more sources

Melanopsin retinal ganglion cell loss in Alzheimer disease [PDF]

Annals of Neurology, 2015
ObjectiveMelanopsin retinal ganglion cells (mRGCs) are photoreceptors driving circadian photoentrainment, and circadian dysfunction characterizes Alzheimer disease (AD). We investigated mRGCs in AD, hypothesizing that they contribute to circadian dysfunction.MethodsWe assessed retinal nerve fiber layer (RNFL) thickness by optical coherence tomography ...
LA MORGIA, CHIARA, Ross Cisneros, Fred N, Koronyo, Yosef, Hannibal, Jens, GALLASSI, ROBERTO, Cantalupo, Gaetano, SAMBATI, LUISA, Pan, Billy X, Tozer, Kevin R, Barboni, Piero, PROVINI, FEDERICA, Avanzini, Pietro, Carbonelli, Michele, Pelosi, Annalisa, Chui, Helena, LIGUORI, ROCCO, BARUZZI, AGOSTINO, Koronyo Hamaoui, Maya, Sadun, Alfredo A, CARELLI, VALERIO   +19 more
openaire   +7 more sources

Intrinsically Photosensitive (Melanopsin) Retinal Ganglion Cell Function in Glaucoma [PDF]

Investigative Opthalmology & Visual Science, 2011
To determine whether glaucoma alters intrinsically photosensitive retinal ganglion cell (ipRGC) function.Forty-one patients (25 with glaucoma and 16 healthy age-matched control participants) were tested. Intrinsically photosensitive retinal ganglion cell function was directly measured by the sustained, postillumination pupil response (PIPR).
Feigl, Beatrix, Mattes, Dietmar, Thomas, Ravi, Zele, Andrew J.   +3 more
openaire   +3 more sources

Signalling by melanopsin (OPN4) expressing photosensitive retinal ganglion cells [PDF]

Eye, 2016
Over the past two decades there have been significant advances in our understanding of both the anatomy and function of the melanopsin system. It has become clear that rather than acting as a simple irradiance detector the melanopsin system is in fact far more complicated.
S, Hughes, A, Jagannath, J, Rodgers, M W, Hankins, S N, Peirson, R G, Foster   +5 more
openaire   +2 more sources

The neurobiology of circadian rhythms [PDF]

, 2009
Purpose of review There is growing awareness of the importance of circadian rhythmicity in various research fields. Exciting developments are ongoing in the field of circadian neurobiology linked to sleep, food intake, and memory.
Boersma, Gretha J.,, Hut, Roelof A.,, Zee, Eddy A. van der,   +2 more
core   +5 more sources