Results 21 to 30 of about 7,378 (211)

Melanopsin-Positive Intrinsically Photosensitive Retinal Ganglion Cells: From Form to Function [PDF]

The Journal of Neuroscience, 2011
Melanopsin imparts an intrinsic photosensitivity to a subclass of retinal ganglion cells (ipRGCs). Generally thought of as irradiance detectors, ipRGCs target numerous brain regions involved in non-image-forming vision. ipRGCs integrate their intrinsic, melanopsin-mediated light information with rod/cone signals relayed via synaptic connections to ...
Schmidt, Tiffany M., Do, Michael Tri H, Dacey, Dennis, Lucas, Robert, Hattar, Samer, Matynia, Anna   +5 more
openaire   +3 more sources

Melanopsin Driven Light Responses Across a Large Fraction of Retinal Ganglion Cells in a Dystrophic Retina

Frontiers in Neuroscience, 2020
Intrinsically photosensitive retinal ganglion cells (ipRGCs) express the photopigment melanopsin and project to central targets, allowing them to contribute to both image-forming and non-image forming vision.
Cyril G. Eleftheriou, Phillip Wright, Annette E. Allen, Daniel Elijah, Franck P. Martial, Robert J. Lucas   +5 more
doaj   +1 more source

Brain responses to violet, blue, and green monochromatic light exposures in humans: prominent role of blue light and the brainstem. [PDF]

PLoS ONE, 2007
Relatively long duration retinal light exposure elicits nonvisual responses in humans, including modulation of alertness and cognition. These responses are thought to be mediated in part by melanopsin-expressing retinal ganglion cells which are more ...
Gilles Vandewalle, Christina Schmidt, Geneviève Albouy, Virginie Sterpenich, Annabelle Darsaud, Géraldine Rauchs, Pierre-Yves Berken, Evelyne Balteau, Christian Degueldre, André Luxen, Pierre Maquet, Derk-Jan Dijk   +11 more
doaj   +1 more source

Melanopsin-Encoded Response Properties of Intrinsically Photosensitive Retinal Ganglion Cells [PDF]

Neuron, 2016
Melanopsin photopigment expressed in intrinsically photosensitive retinal ganglion cells (ipRGCs) plays a crucial role in the adaptation of mammals to their ambient light environment through both image-forming and non-image-forming visual responses. The ipRGCs are structurally and functionally distinct from classical rod/cone photoreceptors and have ...
Ludovic S, Mure, Megumi, Hatori, Quansheng, Zhu, James, Demas, Irene M, Kim, Surendra K, Nayak, Satchidananda, Panda   +6 more
openaire   +2 more sources

Degeneration of human photosensitive retinal ganglion cells may explain sleep and circadian rhythms disorders in Parkinson’s disease

Acta Neuropathologica Communications, 2018
Parkinson’s disease (PD) patients often suffer from non-motor symptoms like sleep dysregulation, mood disturbances or circadian rhythms dysfunction. The melanopsin-containing retinal ganglion cells are involved in the control and regulation of these ...
Isabel Ortuño-Lizarán, Gema Esquiva, Thomas G. Beach, Geidy E. Serrano, Charles H. Adler, Pedro Lax, Nicolás Cuenca   +6 more
doaj   +1 more source

Melanopsin-Expressing Intrinsically Photosensitive Retinal Ganglion Cells in Retinal Disease

Optometry and Vision Science, 2014
Melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs) are a class of photoreceptors with established roles in non-image-forming processes. Their contributions to image-forming vision may include the estimation of brightness. Animal models have been central for understanding the physiological mechanisms of ipRGC function and
Feigl, Beatrix, Zele, Andrew J.
openaire   +3 more sources

Melanopsin-Containing Retinal Ganglion Cells: Architecture, Projections, and Intrinsic Photosensitivity [PDF]

Science, 2002
The primary circadian pacemaker, in the suprachiasmatic nucleus (SCN) of the mammalian brain, is photoentrained by light signals from the eyes through the retinohypothalamic tract. Retinal rod and cone cells are not required for photoentrainment. Recent evidence suggests that the entraining photoreceptors are retinal ganglion cells (RGCs) that project ...
S, Hattar, H W, Liao, M, Takao, D M, Berson, K W, Yau   +4 more
openaire   +2 more sources

M1 Intrinsically Photosensitive Retinal Ganglion Cells Integrate Rod and Melanopsin Inputs to Signal in Low Light

Cell Reports, 2019
Summary: Light influences various behaviors and physiological processes that occur outside of our conscious perception, including circadian photoentrainment, sleep, and even learning and mood.
Seul Ki Lee, Takuma Sonoda, Tiffany M. Schmidt   +2 more
doaj   +1 more source

Light Activation of the Phosphoinositide Cycle in Intrinsically Photosensitive Chicken Retinal Ganglion Cells [PDF]

, 2010
Purpose: In vertebrates, intrinsically photosensitive retinal ganglion cells (ipRGCs) acting as nonvisual photoreceptors transmit environmental illumination information to the brain, regulating diverse non–image-forming tasks.
Contin, Maria Ana, Giusto, Norma Maria, Guido, Mario Eduardo, Ilincheta, Monica Graciela, Salvador, Gabriela Alejandra, Verra, Daniela Mariana   +5 more
core   +1 more source

Distribution of mammalian-like melanopsin in cyclostome retinas exhibiting a different extent of visual functions.

PLoS ONE, 2014
Mammals contain 1 melanopsin (Opn4) gene that is expressed in a subset of retinal ganglion cells to serve as a photopigment involved in non-image-forming vision such as photoentrainment of circadian rhythms.
Lanfang Sun, Emi Kawano-Yamashita, Takashi Nagata, Hisao Tsukamoto, Yuji Furutani, Mitsumasa Koyanagi, Akihisa Terakita   +6 more
doaj   +1 more source