Results 121 to 130 of about 242,415 (401)

Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions [PDF]

, 2015
A workshop was held at the National Institute for Diabetes and Digestive and Kidney Diseases with a focus on the impact of sleep and circadian disruption on energy balance and diabetes.
Arble, Deanna M, Bass, Joseph, Behn, Cecilia Diniz, Butler, Matthew P, Challet, Etienne, Czeisler, Charles, Depner, Christopher M, Elmquist, Joel, Franken, Paul, Grandner, Michael A, Hanlon, Erin C, Joyner, Michael J, Karatsoreos, Ilia, Keene, Alex C, Kern, Philip A, Klein, Samuel, Morris, Christopher J, Pack, Allan I, Panda, Satchidananda, Ptacek, Louis J, Punjabi, Naresh M, Sassone-Corsi, Paolo, Saxena, Richa, Scheer, Frank A, Scheer, Frank A, Seaquest, Elizabeth R, Thimgan, Matthew S, Van Cauter, Eve, Wright, Kenneth P   +28 more
core   +4 more sources

Introducing the Cis‐2,3‐Bis(trifluoromethyl)cyclopropyl Chemotype: Late‐Stage Installation and Stereoelectronic Properties

ChemistryEurope, EarlyView.
The cis‐2,3‐bis(trifluoromethyl)cyclopropyl chemotype is introduced. The steric demand of this motif is intermediate between that of the heptafluoroisopropyl and prefluorotertbutyl groups; yet, it induces significantly less lipophilicity than these due to its facial polarity.
Daniel Gaviña, Zeyu Feng, David Herrero, Martin Simon, Christopher Golz, Manuel Alcarazo   +5 more
wiley   +1 more source

Melatonin and its metabolites vs oxidative stress: From individual actions to collective protection

Journal of Pineal Research, 2018
Oxidative stress (OS) represents a threat to the chemical integrity of biomolecules including lipids, proteins, and DNA. The associated molecular damage frequently results in serious health issues, which justifies our concern about this phenomenon.
A. Galano, R. Reiter
semanticscholar   +1 more source

Morning Plasma Melatonin Differences in Autism: Beyond the Impact of Pineal Gland Volume

Frontiers in Psychiatry, 2019
While low plasma melatonin, a neuro-hormone synthesized in the pineal gland, has been frequently associated with autism, our understanding of the mechanisms behind it have remained unclear.
Anna Maruani, Anna Maruani, Guillaume Dumas, Anita Beggiato, Anita Beggiato, Nicolas Traut, Hugo Peyre, Alicia Cohen-Freoua, Frédérique Amsellem, Frédérique Amsellem, Monique Elmaleh, David Germanaud, David Germanaud, Jean-Marie Launay, Thomas Bourgeron, Roberto Toro, Richard Delorme, Richard Delorme   +17 more
doaj   +1 more source

Deuteration of Six‐Membered N‐Heteroarenes: Chemistry and Applications

Chemistry – A European Journal, EarlyView.
Deuterated six‐membered N‐Heteroarenes (6NHetAr) are finding utility in an increasing repertoire of applications. Our paper comprehensively reviews synthetic approaches that have been reported for the deuteration of 6NHetAr and their fused counterparts while providing an overview of established and emerging applications for these materials.
Liju Raju, Davide Benedetto Tiz, Adrian Iles, Janez Košmrlj, Ross D. Jansen‐van Vuuren   +4 more
wiley   +1 more source

Critical appraisal and update on the clinical utility of agomelatine, a melatonergic agonist, for the treatment of major depressive disease in adults [PDF]

, 2009
This article describes the pharmacology of the novel atypical antidepressant drug agomelatine, critically reviews and evaluates its clinical use for the treatment of major depression, and suggests areas for further research.
Howland, RH
core   +1 more source

Predicting acute decompensated heart failure using circadian markers from heart rate time series

ESC Heart Failure, EarlyView.
Circadian metrics—amplitude, mesor, and acrophase—derived from a wrist‐worn heart rate monitor can predict acute decompensated heart failure (ADHF) up to 21 days before onset. In 65 post‐ADHF patients, an LSTM model achieved 74% sensitivity, and 73% specificity trained on 21‐day sequences. These findings support circadian rhythm analysis as a promising
Valerie A. A. van Es, Mayke M. C. J. van Leunen, Ignace L. J. de Lathauwer, Cindy C. A. G. Verstappen, René A. Tio, Ruud F. Spee, Lu Yuan, Monica Betta, Giacomo Handjaras, Hareld M. C. Kemps   +9 more
wiley   +1 more source

Binding and dynamics of melatonin at the interface of phosphatidylcholine-cholesterol membranes.

PLoS ONE, 2019
The characterization of interactions between melatonin, one main ingredient of medicines regulating sleeping rhythms, and basic components of cellular plasma membranes (phospholipids, cholesterol, metal ions and water) is very important to elucidate the ...
Huixia Lu, Jordi Martí
doaj   +1 more source

Melatonin for rapid eye movement sleep behavior disorder in Parkinson's disease : a randomised controlled trial [PDF]

, 2019
Background Melatonin may reduce REM-sleep behavior disorder (RBD) symptoms in Parkinson's disease (PD), though robust clinical trials are lacking. Objective To assess the efficacy of prolonged-release (PR) melatonin for RBD in PD.
Coeytaux Jackson, Alessandra, Fang, Bernard A.M., Gilat, Moran, Grunstein, Ron R., Hall, Julie, Hammond, Deborah, Lewis, Simon J. G., Marshall, Nathaniel S., Mullins, Anna E., Wong, Keith K.H., Yee, Brendon J.   +10 more
core   +1 more source

The emerging role of Nrf2 in heart failure: From cardioprotection to therapeutic approaches

ESC Heart Failure, EarlyView.
Nrf2 signalling is impaired in heart failure, contributing to oxidative stress, mitochondrial dysfunction, and ferroptosis, which drive neurohormonal activation, inflammation, and ischaemia‐reperfusion injury. This loss of Nrf2 activity exacerbates hypertension, diabetic cardiomyopathy, and cardiotoxicity, accelerating progression to overt heart ...
Emiliano Fiori, Sergio Davinelli, Armando Ferrera, Alessandro Medoro, Carlo Barsali, Allegra Battistoni, Maurizio Volterrani, Massimo Volpe, Luciano Saso, Speranza Rubattu   +9 more
wiley   +1 more source