ABSTRACT The 2019 coronavirus (COVID‐19) pandemic and associated lockdowns significantly disrupted healthcare systems, including access to pharmacological treatments such as sleep medication. This study investigated the number of first‐time dispensed hypnotic drugs during the first COVID‐19 lockdown in the Netherlands, using data from the Dutch ...
Dana M. Dijkgraaf +5 more
wiley +1 more source
Evaluation of the mechanism underlying melatonin action in cholestatic liver disease treatment via network pharmacology, molecular docking, and in vivo experiments. [PDF]
Li T, ZhenYu J, Jing W.
europepmc +1 more source
ABSTRACT Problems with initiating and maintaining sleep are among the most common health complaints, with prevalence rates exceeding 50% depending on the survey. Preventing the progression to chronic insomnia may reduce public healthcare costs and prevent secondary illnesses.
Maren‐Jo Kater +3 more
wiley +1 more source
Impact of E-Cigarette Use on Circadian Proteins and Cardiovascular Risk Markers. [PDF]
Alzu'bi A +11 more
europepmc +1 more source
Sleep Reactivity Amplifies the Impact of Pre‐Sleep Cognitive Arousal on Sleep Disturbances
This study investigates how sleep reactivity moderates the ‘stress‐pre‐sleep arousal‐sleep’ pathway in university students. At the within‐individual level, both high and low sleep‐reactive groups showed increased pre‐sleep cognitive arousal and sleep disruptions in response to elevated daily stress.
Noof Abdullah Saad Shaif +5 more
wiley +1 more source
Melatonin inhibits FAK signaling to suppress PD-L1 expression and enhance chemosensitivity in triple-negative breast cancer. [PDF]
Wu CC +9 more
europepmc +1 more source
Effects of Agomelatine on Sleep Across Populations: A Systematic Review and Meta‐Analysis
ABSTRACT Agomelatine, a melatoninergic antidepressant, is often prescribed to improve sleep disturbance, though meta‐analytic evidence is currently lacking. This systematic review and meta‐analysis assessed its efficacy and tolerability in sleep outcomes compared to placebo.
Anastasios Stefanou +7 more
wiley +1 more source
Unveiling melatonin's multifaceted actions against ferroptotic neurotoxicity in ischemic stroke. [PDF]
Boonmag S, Reiter RJ, Govitrapong P.
europepmc +1 more source
ABSTRACT Technology use is often implicated in adolescent sleep difficulties, yet experimental evidence confirming its impact on bedtime is critically lacking. This study tested whether online socialising with friends delays bedtime compared to non‐social online media use, while also considering the roles of friendship quality and personality ...
S. V. Bauducco +2 more
wiley +1 more source
Correlation between sleep problems and morning serum melatonin and ferritin levels in Japanese 5-year-old children with autism spectrum disorder. [PDF]
Terui A +7 more
europepmc +1 more source

