Results 41 to 50 of about 118,918 (292)

Melatonin combined with endoplasmic reticulum stress induces cell death via the PI3K/Akt/mTOR pathway in B16F10 melanoma cells.

PLoS ONE, 2014
This study investigated B16F10 melanoma cell death induced by melatonin combined with endoplasmic reticulum (ER) stress through the PI3K/Akt/mTOR pathway.
Han Sung Kim, Tack-Joong Kim, Yeong-Min Yoo   +2 more
doaj   +1 more source

Melatonin reduces intramuscular fat deposition by promoting lipolysis and increasing mitochondrial function

Journal of Lipid Research, 2019
In obesity and diabetes, intramuscular fat (IMF) content correlates markedly with insulin sensitivity, which makes IMF manipulation an area of therapeutic interest.
Kaiqing Liu, Wensai Yu, Wei Wei, Xinbao Zhang, Ye Tian, Melak Sherif, Xin Liu, Chao Dong, Wangjun Wu, Lifan Zhang, Jie Chen   +10 more
doaj   +1 more source

Cardiovascular Benefits of Dietary Melatonin: A Myth or a Reality?

Frontiers in Physiology, 2018
The role of the diet as well as the impact of the dietary habits on human health and disease is well established. Apart from its sleep regulatory effect, the indoleamine melatonin is a well-established antioxidant molecule with multiple health benefits ...
Zukiswa Jiki, Sandrine Lecour, Frederic Nduhirabandi   +2 more
doaj   +1 more source

Inhibition of α-glucosidase by melatonin derivatives: insights from kinetics, docking, and molecular dynamics simulations

Medicine in Drug Discovery
Type 2 diabetes mellitus (T2DM) represents a major global health challenge, emphasizing the need for effective strategies to manage postprandial hyperglycemia.
Ploenthip Puthongking, Bodee Nutho, Muhammad Subhan, Juthamat Ratha, Kiattawee Choowongkomon, Saranyu Khammuang, Kamonpan Sanachai   +6 more
doaj   +1 more source

Melatonin

Dialogues in Clinical Neuroscience, 2002
Melatonin (MEL) is a hormone synthesized and secreted by the pineal gland deep within the brain in response to photoperiodic cues relayed from the retina via an endogenous circadian oscillator within the suprachiasmatic nucleus in the hypothalamus. The circadian rhythm of melatonin production and release, characterized by nocturnal activity and daytime
openaire   +3 more sources

Aging, Melatonin, and the Pro- and Anti-Inflammatory Networks

International Journal of Molecular Sciences, 2019
Aging and various age-related diseases are associated with reductions in melatonin secretion, proinflammatory changes in the immune system, a deteriorating circadian system, and reductions in sirtuin-1 (SIRT1) activity.
R. Hardeland
semanticscholar   +1 more source

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, EarlyView.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

Melatonin Attenuates Cisplatin-Induced Acute Kidney Injury through Dual Suppression of Apoptosis and Necroptosis

Biology, 2019
Melatonin is well known to modulate the sleep−wake cycle. Accumulating evidence suggests that melatonin also has favorable effects such as anti-oxidant and anti-inflammatory properties in numerous disease models. It has been reported that melatonin
Jong Woo Kim, Jungmin Jo, Jung-Yeon Kim, Misun Choe, Jaechan Leem, Jae-Hyung Park   +5 more
doaj   +1 more source

Gut–Metabolome–Proteome Interactions in Age‐Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi‐Omics Analyses

Advanced Science, EarlyView.
Germ‐free (GF) mice receiving fecal microbiota transplantation (FMT) reveal microbiota‐dependent effects on auditory aging. Integrated metagenomic, metabolomic and proteomic profiling maps gut–inner ear network and highlights 5‐hydroxytryptophan (5‐HTP) as a microbiota‐linked metabolic hub in age‐related hearing loss (ARHL).
Ting Yang, Ziwen Gao, Hui Huang, Chanyuan Zhang, Yiquan Tang, Qianhui Qu, Huabin Li, Jing Ke, Zhiji Chen, Menglong Feng, Hu Zhou, Yilai Shu, Wei Yuan   +12 more
wiley   +1 more source

Behavioral changes in the brown planthopper, Nilaparvata lugens, mediated by melatonin

CABI Agriculture and Bioscience, 2021
Background Melatonin has been proved to exist and play importance roles in rice plant, such as biosynthesis and resistance. However, little is known about the function of melatonin in its monophagous pest, the brown planthopper. Methods In this study, we
Longqing Shi, Junian Zhang, Liangmiao Qiu, Zhaowei Jiang, Zhenxing Xie, Zhixiong Zhan   +5 more
doaj   +1 more source