Results 51 to 60 of about 103,843 (303)

Melatonin combined with endoplasmic reticulum stress induces cell death via the PI3K/Akt/mTOR pathway in B16F10 melanoma cells.

PLoS ONE, 2014
This study investigated B16F10 melanoma cell death induced by melatonin combined with endoplasmic reticulum (ER) stress through the PI3K/Akt/mTOR pathway.
Han Sung Kim, Tack-Joong Kim, Yeong-Min Yoo   +2 more
doaj   +1 more source

Melatonin reduces intramuscular fat deposition by promoting lipolysis and increasing mitochondrial function

Journal of Lipid Research, 2019
In obesity and diabetes, intramuscular fat (IMF) content correlates markedly with insulin sensitivity, which makes IMF manipulation an area of therapeutic interest.
Kaiqing Liu, Wensai Yu, Wei Wei, Xinbao Zhang, Ye Tian, Melak Sherif, Xin Liu, Chao Dong, Wangjun Wu, Lifan Zhang, Jie Chen   +10 more
doaj   +1 more source

Behavioral changes in the brown planthopper, Nilaparvata lugens, mediated by melatonin

CABI Agriculture and Bioscience, 2021
Background Melatonin has been proved to exist and play importance roles in rice plant, such as biosynthesis and resistance. However, little is known about the function of melatonin in its monophagous pest, the brown planthopper. Methods In this study, we
Longqing Shi, Junian Zhang, Liangmiao Qiu, Zhaowei Jiang, Zhenxing Xie, Zhixiong Zhan   +5 more
doaj   +1 more source

The role of melatonin in the development of postmenopausal osteoporosis

Frontiers in Pharmacology, 2022
Melatonin is an important endogenous hormone that modulates homeostasis in the microenvironment. Recent studies have indicated that serum melatonin levels are closely associated with the occurrence and development of osteoporosis in postmenopausal women.
Keda Yang, Xueshan Qiu, Lili Cao, Shui Qiu   +3 more
doaj   +1 more source

Melatonin

Dialogues in Clinical Neuroscience, 2002
Melatonin (MEL) is a hormone synthesized and secreted by the pineal gland deep within the brain in response to photoperiodic cues relayed from the retina via an endogenous circadian oscillator within the suprachiasmatic nucleus in the hypothalamus. The circadian rhythm of melatonin production and release, characterized by nocturnal activity and daytime
openaire   +3 more sources

The effects of acute melatonin supplementation on central and peripheral responses in healthy humans during sympathetic stimuli [PDF]

, 2023
There is evidence that melatonin has more functions other than regulating sleeping tendencies such as anti-hypertensive and antioxidant functions, however how melatonin exerts these functions is unknown.
Skillett, Sarah
core  

Understanding the role of melatonin in cancer metabolism [PDF]

, 2019
Oncogenes alters metabolic pathways while the resulted metabolites, in turn, modifies the expression and production of oncogenes or tumor suppressors.
Rodríguez González, Pablo, Mayo Barrallo, Juan Carlos, García Alonso, José Ignacio, Sainz Menéndez, Rosa María, Quirós González, Isabel, Cernuda Cernuda, Rafael, Hevia Sánchez, David   +6 more
core   +1 more source

Inhibition of α-glucosidase by melatonin derivatives: insights from kinetics, docking, and molecular dynamics simulations

Medicine in Drug Discovery
Type 2 diabetes mellitus (T2DM) represents a major global health challenge, emphasizing the need for effective strategies to manage postprandial hyperglycemia.
Ploenthip Puthongking, Bodee Nutho, Muhammad Subhan, Juthamat Ratha, Kiattawee Choowongkomon, Saranyu Khammuang, Kamonpan Sanachai   +6 more
doaj   +1 more source

Melatonin Attenuates Cisplatin-Induced Acute Kidney Injury through Dual Suppression of Apoptosis and Necroptosis

Biology, 2019
Melatonin is well known to modulate the sleep−wake cycle. Accumulating evidence suggests that melatonin also has favorable effects such as anti-oxidant and anti-inflammatory properties in numerous disease models. It has been reported that melatonin
Jong Woo Kim, Jungmin Jo, Jung-Yeon Kim, Misun Choe, Jaechan Leem, Jae-Hyung Park   +5 more
doaj   +1 more source

Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker‐Defined Synucleinopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub, Michele K. York, Roseanne Dobkin, Anuprita R. Nair, Ryan Kurth, David‐Erick Lafontant, Chelsea Caspell‐Garcia, Roy N. Alcalay, Ethan G. Brown, Lana M. Chahine, Christopher Coffey, Tatiana Foroud, Douglas Galasko, Karl Kieburtz, Kenneth Marek, Kalpana Merchant, Brit Mollenhauer, Kathleen L. Poston, Andrew Siderowf, Cristina Simonet, Tanya Simuni, Caroline M. Tanner, Thomas F. Tropea, Aleksandar Videnovic, The Parkinson's Progression Markers Initiative   +24 more
wiley   +1 more source