Results 71 to 80 of about 108,758 (309)

Comparative Pharmacokinetics of Sustained-Release versus Immediate-Release Melatonin Capsules in Fasting Healthy Adults: A Randomized, Open-Label, Cross-Over Study

Pharmaceutics
Background: Exogenous melatonin, a nutraceutical for maintaining a healthy sleep–wake cycle and managing sleep disorders, requires large, repeated doses due to its low bioavailability and short half-life.
Shefali Thanawala, R. Abiraamasundari, Rajat Shah   +2 more
doaj   +1 more source

The Investigation of the Effects of Melatonin on Electrocardiografic Findings in Rats Undergoing Acute Intense Exercise [PDF]

, 2021
Aim:Acute intense exercise causes an additional strain on cardiovascular system. Melatonin has been known as a hormone with cardiovascular protective effects.
Metehan UZUN, Cakan, Pinar, Uzun, Metehan, Pınar ÇAKAN, Çakan, Pınar   +4 more
core   +1 more source

Prevalence of Dietary Supplement Use and Potential Medication Interactions Among Adults With Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to characterize the prevalence and correlates of dietary supplement use, identify commonly used supplements, and evaluate potential supplement–medication interactions among adults with systemic lupus erythematosus (SLE).
Sarah L. Patterson, Russell Ellyson, Jessica Fitzpatrick, Ghizlane Yaakoubi, Bradley Pearce, S. Sam Lim, Jinoos Yazdany, Laura C. Plantinga   +7 more
wiley   +1 more source

Effects of photodynamic therapy using bisdemethoxycurcumin combined with melatonin or acetyl-melatonin on C. Albicans

Scientific Reports
The current study aims to explore the efficacy of antifungal photodynamic therapy (PDT) on C. albicans biofilms by combining photosensitizers, bisdemethoxycurcumin (BDMC), and melatonin (MLT) or acetyl-melatonin (AcO-MLT).
Maria Margarita D. Duterte, Noppawan Phumala Morales, Waranuch Pitiphat, Ploenthip Puthongking, Teerasak Damrongrungruang   +4 more
doaj   +1 more source

Importance of Melatonin in Assisted Reproductive Technology and Ovarian Aging

International Journal of Molecular Sciences, 2020
Melatonin is probably produced in all cells but is only secreted by the pineal gland. The pineal secretion of melatonin is determined by the light–dark cycle, and it is only released at night.
H. Tamura, Mai Jozaki, Manabu Tanabe, Yuichiro Shirafuta, Yumiko Mihara, Masahiro Shinagawa, I. Tamura, R. Maekawa, Shun Sato, T. Taketani, A. Takasaki, R. Reiter, N. Sugino   +12 more
semanticscholar   +1 more source

Melatonin

Dialogues in Clinical Neuroscience, 2002
Melatonin (MEL) is a hormone synthesized and secreted by the pineal gland deep within the brain in response to photoperiodic cues relayed from the retina via an endogenous circadian oscillator within the suprachiasmatic nucleus in the hypothalamus. The circadian rhythm of melatonin production and release, characterized by nocturnal activity and daytime
openaire   +3 more sources

Identification of Melatonin-Regulated Genes in the Ovine Pituitary Pars Tuberalis, a Target Site for Seasonal Hormone Control [PDF]

, 2008
The pars tuberalis (PT) of the pituitary gland expresses a high density of melatonin (MEL) receptors and is believed to regulate seasonal physiology by decoding changes in nocturnal melatonin secretion.
Davis, Julian R. E., Talbot, Richard, Dupre, Sandrine M., Loudon, Andrew S I; id_orcid, Waddington, D., Downing, A., Burt, D.W., Davis, Julian R E, Loudon, A.S.I., Talbot, R., Mouzaki, D., Davis, J.R.E., Downing, Alison, Lincoln, Gerald A., Mouzaki, Daphne, Dupré, S.M., Burt, Dave W., Lincoln, G.A., Waddington, David, Loudon, Andrew S. I., Dupre, Sandrine, Malpaux, Benoit   +21 more
core   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

Melatonin secretion in a strictly subterranean mammal, the Damaraland mole-rat (Cryptomys damarensis) [PDF]

, 2003
Subterranean mammals inhabit an environment that is normally devoid of light and are therefore deprived of photoperiodic information that can be used to time important life-history events.
N. C. Bennett, Fleming, P.A., B. Malpaux, A. J. Molteno, Bennett, N.C., Richter, T.A., Molteno, A.J., P. A. Fleming, Malpaux, Benoit, Malpaux, B., T. A. Richter   +10 more
core  

Understanding the role of melatonin in cancer metabolism [PDF]

, 2019
Oncogenes alters metabolic pathways while the resulted metabolites, in turn, modifies the expression and production of oncogenes or tumor suppressors.
Rodríguez González, Pablo, Mayo Barrallo, Juan Carlos, García Alonso, José Ignacio, Sainz Menéndez, Rosa María, Quirós González, Isabel, Cernuda Cernuda, Rafael, Hevia Sánchez, David   +6 more
core   +1 more source