Results 71 to 80 of about 103,843 (303)
Advanced Science, EarlyView.This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang +16 more
wiley +1 more source
PLoS ONE, 2020 Melatonin (MT; N-acetyI-5-methoxytryptamine) is an amine hormone involved in abiotic stress resistance. Previous studies have confirmed that melatonin can promote seed germination, mediate physiological regulation mechanisms, and stimulate crop growth ...
Li Chen +10 more
doaj +1 more source
Melatonin biosynthesis pathways in nature and its production in engineered microorganisms
Synthetic and Systems Biotechnology, 2022 Melatonin is a biogenic amine that can be found in plants, animals and microorganism. The metabolic pathway of melatonin is different in various organisms, and biosynthetic endogenous melatonin acts as a molecular signal and antioxidant protection ...
Xiaotong Xie +6 more
doaj +1 more source
Deconstruction of Human Age‐Related Cataract Capsules Defines Aging
Advanced Science, EarlyView.We generate a comprehensive atlas of age‐related cataracts (ARC) at a single‐cell resolution, encompassing three disease states—mild cataract group (Mild), severe cortical cataract group (Severe_C), and severe nuclear cataract group (Severe_N). We find that ARC involves seven distinct lens capsule cell types, with notable differences in cellular ...
Qiaomei Tang +9 more
wiley +1 more source
Effects of oral administration of melatonin on bone metabolism [PDF]
, 2001 P(論文)We have recently demonstrated that melatonin stimulates proliferation and type I collagen synthesis of normal human osteoblastic cells in vitro. We have further shown that daily I.P.
政所, 明弘 +9 more
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A literature research on melatonin with a focus on plant-based products
, 2023 reservedMelatonin is a ubiquitous molecule found widely across the animal and vegetal kingdoms as well as in microorganisms. Melatonin has various advantages for human wellness, among which there are sleep regulation and enhancement of the body's ...
ADELMI, ALISSA
core
Single‐Atom‐Enhanced Fully Inkjet‐Printed Electrochemical Sensor for Dopamine Detection
Advanced Science, EarlyView.Fully inkjet‐printed paper‐based dopamine sensors are fabricated using nitrogen‐doped graphene acid functionalized with copper single atoms. The copper sites uniquely enhance dopamine oxidation through strong molecular adsorption, as verified by electrochemical measurements and DFT calculations. The approach highlights the potential of single‐atom inks
Martin‐Alex Nalepa +11 more
wiley +1 more source
Melatonin, immune function and cancer [PDF]
, 2011 Melatonin is a natural substance ubiquitous in distribution and present in almost all species ranging from unicellular organisms to humans. In mammals, melatonin is synthesized not only in the pineal gland but also in many other parts of the body ...
Bhatnagar, Kunwar P. +7 more
core +1 more source
Advanced Science, EarlyView.SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long +12 more
wiley +1 more source
A novel study of melatonin diffusion in a 3-D cell culture model [PDF]
, 2023 Melatonin is now considered a major physiological regulator of many different functions including synchronization of circadian rhythms, antioxidant defense at different levels, immunomodulation, cell growth control, neuroprotector and anti-tumor agent ...
Fernández Vega, Sheila +9 more
core +1 more source