Results 91 to 100 of about 103,843 (303)

Natural melatonin fluctuation and its minimally invasive simulation in the zebra finch [PDF]

PeerJ, 2016
Melatonin is a key hormone in the regulation of circadian rhythms of vertebrates, including songbirds. Understanding diurnal melatonin fluctuations and being able to reverse or simulate natural melatonin levels are critical to investigating the influence
Susanne Seltmann, Lisa Trost, Andries Ter Maat, Manfred Gahr   +3 more
doaj   +2 more sources

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Melatonin Is Involved in Regulation of Bermudagrass Growth and Development and Response to Low K+ Stress

Frontiers in Plant Science, 2017
Melatonin (N-acetyl-5-methoxytryptamine) plays critical roles in plant growth and development and during the response to multiple abiotic stresses. However, the roles of melatonin in plant response to K+ deficiency remain largely unknown.
Liang Chen, Jibiao Fan, Zhengrong Hu, Zhengrong Hu, Xuebing Huang, Xuebing Huang, Erick Amombo, Erick Amombo, Ao Liu, Ao Liu, Aoyue Bi, Aoyue Bi, Ke Chen, Yan Xie, Jinmin Fu   +14 more
doaj   +1 more source

Melatonin-Induced Protective Effects on Cardiomyocytes Against Reperfusion Injury Partly Through Modulation of IP3R and SERCA2a Via Activation of ERK1

, 2018
Resumo Background: Melatonin is a neuroendocrine hormone synthesized primarily by the pineal gland that is indicated to effectively prevent myocardial reperfusion injury.
Shunying Hu (4958965), Pingjun Zhu (4958962), Hao Zhou (136535), Ying Zhang (1235337), Yundai Chen (303103)   +4 more
core   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

The MoSR‐MoDde1 Regulatory Axis: A Novel Determinant of DMI Sensitivity and a Target for Sustainable Rice Blast Control

Advanced Science, EarlyView.
The transcription factor MoSR governs DMI fungicide sensitivity in Magnaporthe oryzae through dual regulation of ergosterol biosynthesis and the detoxification enzyme MoDde1. Targeting MoDde1 via a small‐molecule inhibitor or host‐induced gene silencing enhances DMI efficacy against rice blast, offering a sustainable disease management strategy ...
Fan‐Zhu Meng, Wen‐Kai Wei, Meng‐Yao Wu, Min‐Zheng Cai, Yu‐Fu Wang, Li Zhao, Shuai Meng, Liang‐Fen Yin, Guido Schnabel, Wei‐Xiao Yin, Chao‐Xi Luo   +10 more
wiley   +1 more source

Melatonin bridges timekeeping and survival: coordinating diurnal rhythms, autophagy, and energy balance in upland cotton

Plant Stress
Melatonin is widely recognized for its regulatory role in animal circadian rhythms, but its functional significance in plant chronobiology, especially its integration with energy metabolism and autophagy, remains poorly understood.
Laha Supriya, Deepika Dake, Nyanthanglo Woch, Kritika Chauhan, Richa Lobiyal, Mehanathan Muthamilarasan, Gudipalli Padmaja   +6 more
doaj   +1 more source

Binding and dynamics of melatonin at the interface of phosphatidylcholine-cholesterol membranes.

PLoS ONE, 2019
The characterization of interactions between melatonin, one main ingredient of medicines regulating sleeping rhythms, and basic components of cellular plasma membranes (phospholipids, cholesterol, metal ions and water) is very important to elucidate the ...
Huixia Lu, Jordi Martí
doaj   +1 more source

Melatonin and chronic ethanol consumption: effects on the offspring liver and kidney

, 2023
The aim of this research was to assess whether the administration of melatonin during pregnancy and lactation can mitigate alcohol-induced liver and kidney damage in the offspring. Three groups were formed with the offspring of 30 albino Wistar rats from
Yasmim Barbosa dos Santos
core