Results 21 to 30 of about 157,757 (253)

The effect of melatonin on bacterial translocation following ischemia/reperfusion injury in a rat model of superior mesenteric artery occlusion [PDF]

, 2015
Background: Acute mesenteric ischemia is a life-threatening vascular emergency resulting in tissue destruction due to ischemia-reperfusion injury. Melatonin, the primary hormone of the pineal gland, is a powerful scavenger of reactive oxygen species (ROS)
Aydin, B., Aydin, C., Berber, I., Birsen, O., Cevahir, N., Gumrukcu, G., Yenisey, C., Özban, Murat.   +7 more
core   +2 more sources

Effects of Duodenal 5-Hydroxytryptophan Perfusion on Melatonin Synthesis in GI Tract of Sheep

Molecules, 2021
The purpose of this study is to investigate the potential effects of 5-hydroxytryptophan (5-HTP) duodenal perfusion on melatonin (MT) synthesis in the gastrointestinal (GI) tract of sheep.
Jun Pan, Fengming Li, Caidie Wang, Xiaobin Li, Shiqi Zhang, Wenjie Zhang, Guodong Zhao, Chen Ma, Guoshi Liu, Kailun Yang   +9 more
doaj   +1 more source

Anti-oxidants in Parkinson's disease therapy: a critical point of view [PDF]

, 2016
Parkinson's disease (PD) is a degenerative neurological syndrome, which is characterized by the preferential death of dopaminergic (DAergic) neurons in the SubstantiaNigra.
Beltramini, Mariano, Bisaglia, Marco, Bubacco, Luigi, Filograna, Roberta   +3 more
core   +2 more sources

A Review of Melatonin, Its Receptors and Drugs

Eurasian Journal of Medicine, 2019
After a Turkish scientist took Nobel Prize due to his contributions to understand clock genes, melatonin, closely related to these genes, may begin to shine.
Mucahit Emet, Halil Ozcan, Lutfu Ozel, Muhammed Yayla, Zekai Halici, Ahmet Hacimuftuoglu   +5 more
doaj   +1 more source

Melatonin suppresses sympathetic vasomotor tone through enhancing GABAA receptor activity in the hypothalamus

Frontiers in Physiology, 2023
Introduction: Melatonin (5-methoxy-N-acetyl-tryptamine) is a circadian hormone synthesized and secreted by the pineal gland. In addition to regulating circadian rhythms of many physiological functions, melatonin is involved in regulating autonomic ...
Qiyao Yu, Qiyao Yu, Qi Guo, Qi Guo, Sheng Jin, Chao Gao, Peiru Zheng, De-Pei Li, Yuming Wu, Yuming Wu   +9 more
doaj   +1 more source

Myopes have significantly higher serum melatonin concentrations than non-myopes [PDF]

, 2017
Purpose Experimental animal models of myopia demonstrate that higher melatonin (Mel) and lower dopamine (DA) concentrations actively promote axial elongation.
Ackermann, Atkinson, Ayaki, Baba, Barnard, Beck-Friis, Benavente-Pérez, Benloucif, Berg, Bertolet, Besharse, Breslin, Brown, Cahill, Chang, Chiba, Chua, Delgado, Dong, Eisenberg, Fan, Freedman, Guo, Hammond, He, Hua, Huang, Huang, Hughes, Iuvone, Jee, Kivelä, Lanyon, Logan, Lu, Mallen, Mao, Martin, McCullough, Megaw, Megaw, Nickla, Nickla, Ohngemach, Panda, Pendrak, Rada, Rao, Riefahn, Rohrer, Rose, Rudnicka, Sankaridurg, Skene, Stone, Stone, Stormann, Tosini, Trier, Verkicharla, Wahl, Wallman, Wang, Weiss, Wiechmann, Wiechmann, Wilson, Witkovsky, Wu, Xu, Zhang   +70 more
core   +2 more sources

Melatonin Modulates the GABAergic Response in Cultured Rat Hippocampal Neurons

Journal of Pharmacological Sciences, 2012
In the present study, we investigated the effect of melatonin on the GABA-induced current (IGABA) and GABAergic miniature inhibitory postsynaptic currents (mIPSCs) in cultured rat hippocampal neurons using the whole-cell patch-clamp technique.
Xin-Ping Cheng, Hao Sun, Zeng-You Ye, Jiang-Ning Zhou   +3 more
doaj   +1 more source

Melatonin distribution reveals clues to its biological significance in basal metazoans.

PLoS ONE, 2012
Although nearly ubiquitous in nature, the precise biological significance of endogenous melatonin is poorly understood in phylogenetically basal taxa.
Modi Roopin, Oren Levy
doaj   +1 more source

Randomized trial of polychromatic blue-enriched light for circadian phase shifting, melatonin suppression, and alerting responses. [PDF]

, 2019
Wavelength comparisons have indicated that circadian phase-shifting and enhancement of subjective and EEG-correlates of alertness have a higher sensitivity to short wavelength visible light.
Ayers, M., Brainard, G. C., Byrne, B., Cecil, K., Gerner, E., Hanifin, J. P., Jablonski, M., James, M., Lockley, S. W., Pineda, C., Rollag, M., Warfield, B., West, K.   +12 more
core   +2 more sources

Modulation of melatonin to the thalamic lesion-induced pain and comorbid sleep disturbance in the animal model of the central post-stroke hemorrhage

Molecular Pain, 2022
The devastating chronic central post stroke pain is associated with variety of comorbidities. Disrupted sleep is a severe comorbidity, causing an increase in the suicide rate, due to CPSP’s pain symptom.
Tavleen Kaur, Hsi-Chien Shih, Andrew Chih Wei Huang, Bai-Chuang Shyu   +3 more
doaj   +1 more source