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The International Journal of Biochemistry & Cell Biology, 2006 Melatonin, originally discovered as a hormone of the pineal gland, is produced by bacteria, protozoa, plants, fungi, invertebrates, and various extrapineal sites of vertebrates, including gut, skin, Harderian gland, and leukocytes. Biosynthetic pathways seem to be identical.
Hardeland, Ruediger +2 more
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A Review of Melatonin, Its Receptors and Drugs
Eurasian Journal of Medicine, 2019 After a Turkish scientist took Nobel Prize due to his contributions to understand clock genes, melatonin, closely related to these genes, may begin to shine.
Mucahit Emet +5 more
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Frontiers in Physiology, 2023 Introduction: Melatonin (5-methoxy-N-acetyl-tryptamine) is a circadian hormone synthesized and secreted by the pineal gland. In addition to regulating circadian rhythms of many physiological functions, melatonin is involved in regulating autonomic ...
Qiyao Yu +9 more
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Journal of Sleep Research, 1996 The hypnotic action of melatonin 5 mg p.o. was explored in 15 subjects with psychophysiological insomnia in a double‐blind controlled self‐report questionnaire study. Melatonin or placebo was taken at 20.00 hours for a 1‐week period in random order.
C M, Ellis, G, Lemmens, J D, Parkes
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Melatonin Modulates the GABAergic Response in Cultured Rat Hippocampal Neurons
Journal of Pharmacological Sciences, 2012 In the present study, we investigated the effect of melatonin on the GABA-induced current (IGABA) and GABAergic miniature inhibitory postsynaptic currents (mIPSCs) in cultured rat hippocampal neurons using the whole-cell patch-clamp technique.
Xin-Ping Cheng +3 more
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Identification of Melatonin-Regulated Genes in the Ovine Pituitary Pars Tuberalis, a Target Site for Seasonal Hormone Control [PDF]
, 2008 The pars tuberalis (PT) of the pituitary gland expresses a high density of melatonin (MEL) receptors and is believed to regulate seasonal physiology by decoding changes in nocturnal melatonin secretion.
Davis, Julian R. E. +21 more
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Archives of Disease in Childhood, 2005 There have been conflicting reports of the effects on seizure control of prescribing melatonin for people with epilepsy.1–4 We undertook a retrospective before-and-after observational study of 13 young people prescribed melatonin for sleep disturbances at the David Lewis Centre, a residential school for children and young adults with severe epilepsy ...
C, Jones, M, Huyton, D, Hindley
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Melatonin distribution reveals clues to its biological significance in basal metazoans.
PLoS ONE, 2012 Although nearly ubiquitous in nature, the precise biological significance of endogenous melatonin is poorly understood in phylogenetically basal taxa.
Modi Roopin, Oren Levy
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Melatonin regulates gene expressions through activating auxin synthesis and signaling pathways
Frontiers in Plant Science, 2022 BackgroundBoth melatonin and indole-3-acetic acid (IAA) are derived from tryptophan. And the most interesting and unsolved puzzle in melatonin research is that what is the relationship between melatonin and auxin?MethodsIn this study, we performed ...
Wei Wei +6 more
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Analysis of melatonin content and gene expression in Chinese cherry leaves [PDF]
E3S Web of Conferences, 2020 To investigate the accumulation characteristics and mechanism of melatonin in cherry leaves of different leaf ages, the melatonin content and the expression of synthetic genes in cherry leaves of different leaf ages were measured. The results showed that
Wang Xin +7 more
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