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Melatonin is the principal hormone secreted by the pineal gland, produced in humans with a circadian rhythm characterized by elevated blood levels during the night. It is involved in the regulation of several rhythmic functions in various vertebrates, and participates in the processing of photoperiodic information.
MOR, Marco +3 more
+9 more sources
The hypnotic action of melatonin 5 mg p.o. was explored in 15 subjects with psychophysiological insomnia in a double‐blind controlled self‐report questionnaire study. Melatonin or placebo was taken at 20.00 hours for a 1‐week period in random order.
C M, Ellis, G, Lemmens, J D, Parkes
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In vitro cytoprotective and in vivo anti-oral mucositis effects of melatonin and its derivatives [PDF]
According to our preliminary study, melatonin and its N-amide derivatives (N-(2-(1-4-bromobenzoyl-5-methoxy-1H-indol-3-yl)ethyl)acetamide (BBM) and 4-bromo-N-(2-(5-methoxy-1H-indol-3-yl)ethyl)benzamide (EBM)) inhibited the marker of acute inflammation in
Pramote Mahakunakorn +6 more
doaj +2 more sources
There have been conflicting reports of the effects on seizure control of prescribing melatonin for people with epilepsy.1–4 We undertook a retrospective before-and-after observational study of 13 young people prescribed melatonin for sleep disturbances at the David Lewis Centre, a residential school for children and young adults with severe epilepsy ...
C, Jones, M, Huyton, D, Hindley
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Melatonin is a new kind of plant growth regulator. The aim of this study was to figure out the effect of melatonin on arbuscular mycorrhizal (AM) symbiosis and heavy metal tolerance.
Xiangyu Zhang +4 more
doaj +1 more source
Melatonin and Melatonin-Rich Foods
Vegetables and fruits are found in the most popular diets. And they are considered as rich sources of vitamins and minerals. Vitamin and mineral deficiency are one of the major causes of various diseases that are common nowadays. Especially vitamins which are known to affect directly on various hormones in our body.
İhsan ŞAT, Halil İbrahim BİNİCİ
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Once thought to be exclusively a molecule of the animal kingdom, melatonin has now been found to exist in plants as well. Among a number of actions, melatonin is a direct free radical scavenger and an indirect antioxidant. Melatonin directly detoxifies the hydroxyl radical (OH), hydrogen peroxide, nitric oxide, peroxynitrite anion, peroxynitrous acid ...
R J, Reiter +3 more
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Melatonin interacts in multiple ways with microglia, both directly and, via routes of crosstalk with astrocytes and neurons, indirectly. These effects of melatonin are of relevance in terms of antioxidative protection, not only concerning free-radical detoxification, but also in prevention of processes that cause, promote, or propagate oxidative stress
Hardeland, Rüdiger +1 more
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Background Melatonin is considered to be a polyfunctional master regulator in animals and higher plants. Exogenous melatonin inhibits plant infection by multiple diseases; however, the role of melatonin in Cucumber green mottle mosaic virus (CGMMV ...
Ling-Ling Yang +10 more
doaj +1 more source
A Review of Melatonin, Its Receptors and Drugs
After a Turkish scientist took Nobel Prize due to his contributions to understand clock genes, melatonin, closely related to these genes, may begin to shine.
Mucahit Emet +5 more
doaj +1 more source

