Results 51 to 60 of about 118,918 (292)
Melatonin biosynthesis pathways in nature and its production in engineered microorganisms
Synthetic and Systems Biotechnology, 2022 Melatonin is a biogenic amine that can be found in plants, animals and microorganism. The metabolic pathway of melatonin is different in various organisms, and biosynthetic endogenous melatonin acts as a molecular signal and antioxidant protection ...
Xiaotong Xie +6 more
doaj +1 more source
Advanced Science, EarlyView.A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil +7 more
wiley +1 more source
PharmaceuticsBackground: Exogenous melatonin, a nutraceutical for maintaining a healthy sleep–wake cycle and managing sleep disorders, requires large, repeated doses due to its low bioavailability and short half-life.
Shefali Thanawala +2 more
doaj +1 more source
Importance of Melatonin in Assisted Reproductive Technology and Ovarian Aging
International Journal of Molecular Sciences, 2020 Melatonin is probably produced in all cells but is only secreted by the pineal gland. The pineal secretion of melatonin is determined by the light–dark cycle, and it is only released at night.
H. Tamura +12 more
semanticscholar +1 more source
A Renal Clearable Probe for In Vivo Monoamine Oxidase (MAO) Detection
Advanced Science, EarlyView.A renal‐clearable Cy7‐based fluorogenic probe enables rapid and non‐invasive detection of monoamine oxidase (MAO) activity in vivo. Upon MAO‐mediated activation, the fluorescent product is efficiently excreted in urine, allowing direct quantification of enzyme overexpression.
Marcia Domínguez +13 more
wiley +1 more source
Scientific ReportsThe current study aims to explore the efficacy of antifungal photodynamic therapy (PDT) on C. albicans biofilms by combining photosensitizers, bisdemethoxycurcumin (BDMC), and melatonin (MLT) or acetyl-melatonin (AcO-MLT).
Maria Margarita D. Duterte +4 more
doaj +1 more source
Plant‐Derived Melatonin Inhibits Bacterial Virulence via CpxA/R Two‐Component System
Advanced Science, EarlyView.Plant‐derived melatonin is sensed by CpxAE48/T51, which inhibits the phosphorylation cascade transmission from CpxAH240 to CpxRD52, resulting in the inhibition of DNA‐binding capacity of CpxR and subsequent T3SS genes expression in Pst DC3000. ABSTRACT In defending against pathogens, plants deploy diverse secondary metabolites and signaling molecules ...
Jin‐Wei Wei +7 more
wiley +1 more source
Cell Death and Disease, 2019 Melatonin, more commonly known as the sleep hormone, is mainly secreted by the pineal gland in dark conditions and regulates the circadian rhythm of the organism.
Anna Tarocco +6 more
semanticscholar +1 more source
British Journal of Clinical Pharmacology, EarlyView.Prescribing cascades occur when medication is prescribed to prevent/treat the adverse effects of another medication and may be intentional/unintentional. This study examines the prevalence of nine prescribing cascades (ThinkCascades) in The Irish Longitudinal StuDy on Ageing (TILDA).
Ann Sinéad Doherty +7 more
wiley +1 more source
Role of melatonin in sleep deprivation‐induced intestinal barrier dysfunction in mice
Journal of Pineal Research, 2019 Intestinal diseases caused by sleep deprivation (SD) are severe public health threats worldwide. This study focuses on the effect of melatonin on intestinal mucosal injury and microbiota dysbiosis in sleep‐deprived mice.
Ting Gao +7 more
semanticscholar +1 more source