Results 71 to 80 of about 181,700 (339)

PENGARUH PEMBERIAN MELATONIN TERHADAP JUMLAH LEUKOSIT PADA TIKUS WISTAR MODEL SEPSIS [PDF]

, 2016
Background : Melatonin was a free radical frequently used as an antioxidant. Melatonin played a role in increasing immune response, and supporting cytoprotective process.
Riani, Rizqi Indah, Wicaksono, Satrio Adi   +1 more
core  

The effect of melatonin on bacterial translocation following ischemia/reperfusion injury in a rat model of superior mesenteric artery occlusion [PDF]

, 2015
Background: Acute mesenteric ischemia is a life-threatening vascular emergency resulting in tissue destruction due to ischemia-reperfusion injury. Melatonin, the primary hormone of the pineal gland, is a powerful scavenger of reactive oxygen species (ROS)
Aydin, B., Aydin, C., Berber, I., Birsen, O., Cevahir, N., Gumrukcu, G., Yenisey, C., Özban, Murat.   +7 more
core   +2 more sources

Melatonin

Dialogues in Clinical Neuroscience, 2002
Melatonin (MEL) is a hormone synthesized and secreted by the pineal gland deep within the brain in response to photoperiodic cues relayed from the retina via an endogenous circadian oscillator within the suprachiasmatic nucleus in the hypothalamus. The circadian rhythm of melatonin production and release, characterized by nocturnal activity and daytime
openaire   +3 more sources

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

Angewandte Chemie International Edition, Accepted Article.
This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley   +1 more source

Mechanoactivated Celite as a catalyst for C‒H bond perfluoroalkylation and other radical reactions

Angewandte Chemie International Edition, Accepted Article.
Herein we report that Celite (diatomaceous earth) commonly viewed as an innocent filter aid or support material, or Earth‐abundant, non‐toxic metal oxides are efficient mechanoactivated catalysts for arene and heteroarene C‒H bond radical trifluoromethylation and pentafluoroethylation, with the activity comparable with previously reported ...
Thomas J. Hasiweder, Hoan M. Dinh, Dilip K. Pandey, Aleksandr Sorvanov, Julia Khusnutdinova   +4 more
wiley   +1 more source

Supersulfide biology and translational medicine for disease control

British Journal of Pharmacology, EarlyView., 2023
Abstract For decades, the major focus of redox biology has been oxygen, the most abundant element on Earth. Molecular oxygen functions as the final electron acceptor in the mitochondrial respiratory chain, contributing to energy production in aerobic organisms. In addition, oxygen‐derived reactive oxygen species including hydrogen peroxide and nitrogen
Uladzimir Barayeu, Tomohiro Sawa, Motohiro Nishida, Fan‐Yan Wei, Hozumi Motohashi, Takaaki Akaike   +5 more
wiley   +1 more source

Preharvest application of melatonin induces anthocyanin accumulation and related gene upregulation in red pear (Pyrus ussuriensis)

Journal of Integrative Agriculture, 2021
Anthocyanins are important components in the peel of red pears and contribute to the appearance of the fruit. Melatonin application is known to affect anthocyanin biosynthesis, but the effect of preharvest melatonin application on fruit coloration ...
Hui-li SUN, Xin-yue WANG, Ye SHANG, Xiao-qian WANG, Guo-dong DU, De-guo LÜ   +5 more
doaj  

Investigating the protective role of the natural hormone Melatonin, in reducing drug-induced cardiotoxicity in the therapy of chronic diseases [PDF]

, 2019
Heart failure (HF) is a highly complex disorder and a major end-point of cardiovascular diseases (CVD). The pathogenesis of HF is mostly unresolved but involves interplay between cardiac structural and electrical remodelling, metabolic alterations, cell ...
Kasi Ganeshan, T., Kasi Ganeshan, T.
core  

Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions [PDF]

, 2015
A workshop was held at the National Institute for Diabetes and Digestive and Kidney Diseases with a focus on the impact of sleep and circadian disruption on energy balance and diabetes.
Arble, Deanna M, Bass, Joseph, Behn, Cecilia Diniz, Butler, Matthew P, Challet, Etienne, Czeisler, Charles, Depner, Christopher M, Elmquist, Joel, Franken, Paul, Grandner, Michael A, Hanlon, Erin C, Joyner, Michael J, Karatsoreos, Ilia, Keene, Alex C, Kern, Philip A, Klein, Samuel, Morris, Christopher J, Pack, Allan I, Panda, Satchidananda, Ptacek, Louis J, Punjabi, Naresh M, Sassone-Corsi, Paolo, Saxena, Richa, Scheer, Frank A, Scheer, Frank A, Seaquest, Elizabeth R, Thimgan, Matthew S, Van Cauter, Eve, Wright, Kenneth P   +28 more
core   +4 more sources

Melatonin regulates rabbit sperm motility and kinematics via the MT1/PKC signaling pathway [PDF]

Animal Bioscience
Objective Melatonin, a highly conserved molecule, plays an essential role in various physiological functions. Research suggests that incorporating melatonin into semen extender enhances livestock sperm viability.
Chongchong Wang, Yanyan Zhang, Shiwen He, Biao Jiang, Jinglei Huang, Hui Peng   +5 more
doaj   +1 more source