Results 31 to 40 of about 29,812 (167)

Melatonin distribution reveals clues to its biological significance in basal metazoans.

open access: yesPLoS ONE, 2012
Although nearly ubiquitous in nature, the precise biological significance of endogenous melatonin is poorly understood in phylogenetically basal taxa.
Modi Roopin, Oren Levy
doaj   +1 more source

Melatonin Improves Turbot Oocyte Meiotic Maturation and Antioxidant Capacity, Inhibits Apoptosis-Related Genes mRNAs In Vitro

open access: yesAntioxidants, 2023
High-quality eggs are essential for the sustainability of commercial aquaculture production. Melatonin is a potent candidate for regulating the growth and maturation of oocytes.
Jiarong Zhang   +9 more
doaj   +1 more source

Dampening of neurotransmitter action: molecular similarity within the melatonin structure

open access: yesEndocrine Regulations, 2018
Objectives. Melatonin initiates physiologic and therapeutic responses in various tissues through binding to poorly defined MT receptors regulated by G-proteins and purine nucleotides.
Williams Wynford R.
doaj   +1 more source

Melatonin regulates rabbit sperm motility and kinematics via the MT1/PKC signaling pathway [PDF]

open access: yesAnimal Bioscience
Objective Melatonin, a highly conserved molecule, plays an essential role in various physiological functions. Research suggests that incorporating melatonin into semen extender enhances livestock sperm viability.
Chongchong Wang   +5 more
doaj   +1 more source

RORα Regulates Odontoblastic Differentiation and Mediates the Pro-Odontogenic Effect of Melatonin on Dental Papilla Cells

open access: yesMolecules, 2021
Dental papilla cells (DPCs), precursors of odontoblasts, are considered promising seed cells for tissue engineering. Emerging evidence suggests that melatonin promotes odontoblastic differentiation of DPCs and affects tooth development, although the ...
Jun Kang   +7 more
doaj   +1 more source

Melatonin Receptor Genes in Vertebrates [PDF]

open access: yesInternational Journal of Molecular Sciences, 2013
Melatonin receptors are members of the G protein-coupled receptor (GPCR) family. Three genes for melatonin receptors have been cloned. The MT1 (or Mel1a or MTNR1A) and MT2 (or Mel1b or MTNR1B) receptor subtypes are present in humans and other mammals, while an additional melatonin receptor subtype, Mel1c (or MTNR1C), has been identified in fish ...
Di Li   +7 more
openaire   +3 more sources

Temporal expression patterns of the melatoninergic system in the human thymus of children

open access: yesMolecular Metabolism, 2019
Objectives: To obtain greater knowledge of the extra-pineal sources of melatonin during development, the amount of indolamine and the expression levels of the last two enzymes involved in its biosynthesis, Arylalkylamine N-acetyltransferase (AANAT) and ...
Ivan Cruz-Chamorro   +7 more
doaj   +1 more source

Insight of Melatonin: The Potential of Melatonin to Treat Bacteria-Induced Mastitis

open access: yesAntioxidants, 2022
Bovine mastitis is a common inflammatory disease, mainly induced by bacterial pathogens, such as Staphylococcus aureus, Escherichia coli, and Streptococcus agalactiae. Mastitis has negative effects on the production and quality of milk, resulting in huge
Hongyang Li, Peng Sun
doaj   +1 more source

Structural insights into melatonin receptors [PDF]

open access: yesThe FEBS Journal, 2019
The long‐anticipated high‐resolution structures of the human melatonin G protein‐coupled receptors MT1 and MT2, involved in establishing and maintaining circadian rhythm, were obtained in complex with two melatonin analogs and two approved anti‐insomnia and antidepression drugs using X‐ray free‐electron laser serial femtosecond crystallography.
Benjamin Stauch   +2 more
openaire   +2 more sources

Melatonin protects human nucleus pulposus cells from pyroptosis by regulating Nrf2 via melatonin membrane receptors

open access: yesBone & Joint Research, 2023
Aims: This study was performed to explore the effect of melatonin on pyroptosis in nucleus pulposus cells (NPCs) and the underlying mechanism of that effect.
Zhibiao Bai   +5 more
doaj   +1 more source

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