Results 91 to 100 of about 574 (170)

Use of meldonium in the combination treatment of patients with heart failure in the early post-infarction period

Терапевтический архив, 2014
AIM: To evaluate the impact of 10-14-day intravenous administration of meldonium as part of combination therapy in patients with chronic heart failure in the early post-infarction period on the recovery period, structural and functional parameters, and ...
M E Statsenko, N N Shilina, S V Turkina
doaj  

Meldonium: current and emerging therapeutic applications

Postepy biochemii
Meldonium functions as an inhibitor of γ-butyrobetaine hydroxylase, the enzyme responsible for catalyzing the biosynthesis of L-carnitine. By inhibiting mitochondrial β-oxidation of fatty acids under hypoxic conditions, meldonium exerts cytoprotective effects on cardiac, hepatic, and pulmonary tissues.
Halszka, Ponamarczuk, Marcin, Popielarski   +1 more
openaire   +1 more source

Meldonium: dotychczasowe i nowe możliwości terapeutyczne

Postępy Biochemii
Meldonium functions as an inhibitor of γ-butyrobetaine hydroxylase, the enzyme responsible for catalyzing the biosynthesis of L-carnitine. By inhibiting mitochondrial β-oxidation of fatty acids under hypoxic conditions, meldonium exerts cytoprotective effects on cardiac, hepatic, and pulmonary tissues.
Halszka Ponamarczuk, Marcin Popielarski
openaire   +1 more source

Meldonium improves Huntington’s disease mitochondrial dysfunction by restoring peroxisome proliferator‐activated receptor γ coactivator 1α expression

, 2018
Mitochondrial dysfunction seems to play a fundamental role in the pathogenesis of neurodegeneration in Huntington’s disease (HD). We assessed possible neuroprotective actions of meldonium, a small molecule affecting mitochondrial fuel metabolism, in ...
Scialo F., Giordano A, Saturnino C., Giordano, Antonio, Di Cristo, Francesca, Galderisi, Umberto, Gianfranco Peluso., Finicelli M., Francesca Di Cristo, D'Apolito M, Melone M. A. B., Melone, Mariarosa Anna Beatrice, Antonio Giordano, Saturnino C, Valentino A., Mariarosa Anna Beatrice Melone, Filippo Scialò, Finicelli, Mauro, Digilio, Filomena Anna, Galderisi U., D'Apolito M., Saturnino, Carmela, Valentino A, Filomena Anna Digilio, Di Cristo F., Paladino S, Maria D’Apolito, Galderisi U, Peluso G, D’Apolito, Maria, Gianfranco Peluso, Carmela Saturnino, Valentino, Anna, Scialò F, Anna Valentino, Paladino S., Giordano A., Finicelli M, Peluso G., Mauro Finicelli, Peluso, Gianfranco, Di Cristo F, Digilio FA, Umberto Galderisi, Digilio F. A., Paladino, Simona, Scialò, Filippo, Simona Paladino, Melone MAB   +48 more
core   +1 more source

The unusual pharmacokinetics of meldonium: Implications for doping

Pharmacological Research, 2016
Edgars, Liepinsh, Maija, Dambrova
openaire   +2 more sources

Meldonium Inhibits Cell Motility and Wound-Healing in Trabecular Meshwork Cells and Scleral Fibroblasts: Possible Applications in Glaucoma. [PDF]

Pharmaceuticals (Basel), 2023
Minnelli C, Piva F, Cecati M, Armeni T, Mobbili G, Galeazzi R, Melecchi A, Cristaldi M, Corsaro R, Rusciano D.   +9 more
europepmc   +1 more source

Meldonium as a supernosological drug

Consilium Medicum, 2020
openaire   +1 more source

Role of pFox inhibitors in the treatment of patients with acute myocardial ischemia

Терапевтический архив, 2014
AIM: To evaluate the anti-ischemic and anti-anginal efficacy of meldonium (Idrinol) in its short-term use as part of combination therapy in patients with chronic heart failure in the early post-infarction period/MATERIAL AND METHODS: The investigation ...
M E Statsenko, S V Turkina, N N Shilina
doaj  

The effects of meldonium on microrheological abnormalities of erythrocytes in rats with obesity: An experimental study

Background: The microrheological disorders of red blood cells in obesity is often missed by the researchers. This study aimed to report an experimental investigation on laboratory animals with developed obesity and to find out the effect of meldonium on ...
Popova I.A., Zavalishina S.Y., Bondareva I.V., Kulikov E.V., Seleznev S.B., Petrukhina O.A., Vatnikov Y.A., Parshina V.I., Voronina Y.Y., Troshina N.I., Glagoleva T.I.   +10 more
core   +1 more source

Meldonium

Practical Diabetes, 2016
openaire   +2 more sources