Results 81 to 90 of about 13,623 (189)

The Association Between Statin Therapy and the Subsequent Clinical Course of Patients With Melioidosis

Journal of Tropical Medicine, Volume 2025, Issue 1, 2025.
Background: Even in well‐resourced settings, the case‐fatality rate of melioidosis approaches 10%. This has prompted an interest in identifying adjunctive therapies that might improve survival. A prospective, multicentre study in Thailand suggested that statin therapy may reduce the incidence of pneumonia in patients with melioidosis; however, the ...
Laura Prideaux, Hayley Stratton, Meg Sandeman, Simon Smith, Josh Hanson, Lipi Buch   +5 more
wiley   +1 more source

Complete genome sequence of the encephalomyelitic Burkholderia pseudomallei strain MSHR305 [PDF]

, 2013
We describe the complete genome sequence of Burkholderia pseudomallei MSHR305, a clinical isolate taken from a fatal encephalomyelitis case, a rare form of melioidosis. This sequence will be used for comparisons to identify the genes that are involved in
Bruce, David C., Currie, Bart J., Detter, J. Chris, Gelhaus, H. Carl, Johnson, Shannon L., Keim, Paul, Mayo, Mark J., Stone, Joshua K., Tuanyok, Apichai   +8 more
core   +2 more sources

Melioidosis

Current Opinion in Infectious Diseases, 2006
Melioidosis is increasingly recognized around the world. Despite several decades of clinical research, the mortality rate for melioidosis remains high. This review focuses on studies that relate to patient management, including risk factors, diagnosis, treatment and prediction of the outcome.
openaire   +2 more sources

Acanthamoeba castellanii–Mediated Reduction of Interleukin‐1β Secretion and Its Association With Macrophage Autophagy

Scientifica, Volume 2025, Issue 1, 2025.
Noncanonical autophagy including unconventional protein secretion has been extensively studied. Our work focused on a leaderless IL‐1β protein secretion from human macrophage in response to Acanthamoeba castellanii components, Acanthamoeba culture supernatant (CS) and cell lysate (CL), as well as its association with macrophage autophagy.
Rachasak Boonhok, Wilaiwan Senghoi, Suthinee Sangkanu, Chooi Ling Lim, Matsayapan Pudla, Maria de Lourdes Pereira, Polrat Wilairatana, Tooba Mahboob, Md. Atiar Rahman, Pongsak Utaisincharoen, Poonsit Hiransai, Veeranoot Nissapatorn, Simone Carradori   +12 more
wiley   +1 more source

Inactivation of bpsl1039-1040 ATP-binding cassette transporter reduces intracellular survival in macrophages, biofilm formation and virulence in the murine model of Burkholderia pseudomallei infection. [PDF]

, 2018
Burkholderia pseudomallei, a gram-negative intracellular bacillus, is the causative agent of a tropical infectious disease called melioidosis. Bacterial ATP-binding cassette (ABC) transporters import and export a variety of molecules across bacterial ...
Bancroft, Gregory J, Boonyuen, Usa, Cia, Felipe, Cuccui, Jon, Jitprasutwit, Niramol, Korbsrisate, Sunee, Muangsombut, Veerachat, Pinweha, Peechanika, Pumirat, Pornpan, Srinon, Varintip, Thiennimitr, Parameth, Vattanaviboon, Paiboon, Willcocks, Sam, Wren, Brendan W   +13 more
core   +2 more sources

Misdiagnosing Melioidosis

Emerging Infectious Diseases, 2007
Melioidosis is endemic in southern and Southeast Asia and northern Australia. Although relatively few indigenous cases are recognized in the Indian subcontinent, a substantial proportion of cases imported into the United Kingdom originate there, probably reflecting patterns of immigration and travel, and underdiagnosis within the Indian subcontinent.
Brent, A, Matthews, P, Dance, D, Pitt, T, Handy, R   +4 more
openaire   +3 more sources

EMERGENCY PROPHYLAXIS OF EXPERIMENTAL MELIOIDOSIS USING SYNTHETIC IMMUNOMODULATORS AND HETEROLOGOUS VACCINES

RUDN Journal of Medicine, 2018
Melioidosis is a particularly dangerous infection caused by Burkholderia pseudomallei , against which a vaccine has not yet been created. In this regard, the development of effective treatment regimens and emergency prevention of melioidosis is very ...
I A Khabarova, S I Zhukova, K A Rotov, E A Snatenkov, A V Toporkov, D V Viktorov   +5 more
doaj   +1 more source

Melioidosis: a localized osteomyelitis in a cat [PDF]

, 2015
Melioidosis is a zoonotic disease as a result of infection by Burkholderia pseudomallei. It is of significant public health concern due to its ubiquitous nature with high morbidity and mortality in humans and animals.
Ismail, S. S., Lim, May Lyn, Rahman, N., Watanabe, M.   +3 more
core  

Genome-wide saturation mutagenesis of Burkholderia pseudomallei K96243 predicts essential genes and novel targets for antimicrobial development. [PDF]

, 2014
UNLABELLED: Burkholderia pseudomallei is the causative agent of melioidosis, an often fatal infectious disease for which there is no vaccine. B. pseudomallei is listed as a tier 1 select agent, and as current therapeutic options are limited due to its ...
Atkins, Bakshi, Baugh, Chong, Cuccui, Dance, Davidson, Dong, Doublet, Eckert, Figurski, Freiberg, Gallagher, Haque, Holden, Hu, Kang, Karlyshev, Langmead, Langridge, Lewenza, Lynch, Nandi, Ortega, Sadosky, Sarkar-Tyson, Shalom, Sim, Thibault, Tumapa, van Opijnen, van Opijnen, Wiersinga, Yu, Zhang   +34 more
core   +3 more sources

Melioidosis vaccines

Expert Review of Vaccines, 2002
Melioidosis is a disease caused by the facultative intracellular pathogen Burkholderia pseudomallei iand is associated with a high mortality rate. Melioidosis is endemic in the tropics of southeast Asia and northern Australia and is of worldwide concern, particularly as it is a potential agent of bioterrorism or biological warfare.
Jonathan, Warawa, Donald E, Woods
openaire   +2 more sources